AURKC

Description		aurora kinase C
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Spindle Pole Nucleus Chromosome Cytoplasm Centrosome Spindle Cytoskeleton Spindle Microtubule Midbody Chromosome Passenger Complex Spindle Midzone
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Mitotic Spindle Organization Attachment Of Spindle Microtubules To Kinetochore Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly Cell Division Meiotic Cell Cycle
Pathways
Drugs		SNS-314 Fostamatinib
Diseases
GWAS
Novel Interacting Genes		13 novel interacting genes: BIRC5 BIRC7 BRCA1 CADPS CENPA H3C1 INCENP LNX1 NEDD4 NEDD4L OTX2 SRPK1 TACC2
Interacting Genes		13 interacting genes: BIRC5 BIRC7 BRCA1 CADPS CENPA H3C1 INCENP LNX1 NEDD4 NEDD4L OTX2 SRPK1 TACC2
Entrez ID		6795
HPRD ID		04605
Ensembl ID		ENSG00000105146
Uniprot IDs		Q9UQB9
PDB IDs		6GR8 6GR9 9ESA
Enriched GO Terms of Interacting Partners?		Ubiquitin-protein Transferase Activity Chromosome Segregation Microtubule Cytoskeleton Organization Involved In Mitosis Chromosome Ubiquitin Protein Ligase Activity Chromosome Passenger Complex Negative Regulation Of Potassium Ion Export Across Plasma Membrane Protein-containing Complex Organelle Localization Mitotic Cytokinesis Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Sodium Channel Inhibitor Activity Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Potassium Channel Inhibitor Activity Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Spindle Midzone Assembly Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Mitotic Cytokinesis Regulation Of Metaphase Plate Congression Mitotic Spindle Organization Cytoskeleton-dependent Cytokinesis Regulation Of Mitotic Cytokinesis Lateral Element Negative Regulation Of Sodium Ion Transport Nucleoplasm Protein Ubiquitination Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of Cell Cycle Checkpoint RNA Polymerase Binding Receptor Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Enzyme Binding Microtubule-based Process Spindle Organization Chromosome, Centromeric Region Positive Regulation Of Chromosome Segregation Pericentric Heterochromatin Negative Regulation Of Potassium Ion Transport Post-translational Protein Modification Cysteine-type Endopeptidase Inhibitor Activity Microtubule Cytoskeleton Organization Positive Regulation Of Chromosome Separation Neuromuscular Junction Development Positive Regulation Of Cytokinesis
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