IL16 and PPP1R12B

Number of citations of the paper that reports this interaction (PubMedID 12923170)
0

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		IL16	PPP1R12B
Description		interleukin 16	protein phosphatase 1 regulatory subunit 12B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Nuclear Speck Flemming Body	Stress Fiber Nucleoplasm Cytoplasm Cytosol Cytoskeleton Z Disc A Band
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding CD4 Receptor Binding	Enzyme Inhibitor Activity Protein Binding Enzyme Activator Activity Myosin Phosphatase Regulator Activity Phosphatase Regulator Activity Protein Kinase Binding
	Biological Process	Immune System Process Chemotaxis Immune Response Cytokine-mediated Signaling Pathway Leukocyte Chemotaxis Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Inflammatory Response Induction Of Positive Chemotaxis Regulation Of Calcium Ion Transport Positive Regulation Of Neutrophil Activation	Regulation Of Muscle Contraction Signal Transduction Neuron Projection Morphogenesis
Pathways		Other interleukin signaling	RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Body mass index ( 26426971) Brown vs. black hair color ( 30531825) Colorectal cancer (aspirin and/or NSAID use interaction) ( 25781442) Height ( 31562340) Inattentive symptoms ( 18821565) Interleukin-16 levels ( 27989323) Lymphocyte count ( 32888494) Primary biliary cholangitis ( 28425483)	Celiac disease ( 23936387) Chronic obstructive pulmonary disease ( 32824824) Coronary heart disease ( 24778558) Obesity-related traits ( 23251661) Sex ratio ( 26763874)
Interacting Genes		109 interacting genes: ANXA6 BLZF1 BOLA2 BOLA2B CALCOCO2 CAMK1 CARD10 CASP3 CCDC184 CCDC33 CD4 CDK1 CEP72 CSNK2A1 CSNK2A2 CYSRT1 DMRTB1 DUSP7 EFEMP2 FAM124A FHL2 FHL5 FTO GABPB1 GOLGA2 GOLGA6L9 GRIN2A GRIN2B GRIN2C GRIN2D HDAC3 HOMEZ HOOK2 HSF2BP JAKMIP1 KANK2 KCNA3 KCND1 KCND2 KCNJ10 KCNJ15 KCNJ2 KCNJ4 KCTD9 KDM1A KIF16B KIFC3 KRT31 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP3-1 L3MBTL3 LGALS14 LMO3 LNX1 LNX2 MBD3L1 MID2 MIER2 MTUS2 MYOG NOXA1 NTAQ1 OIP5 PCSK6 PDLIM7 PFDN5 PICK1 PPP1R12A PPP1R12B PPP1R12C PPP1R16A PRDM6 PRR13 PSTPIP1 RAPGEF2 RBCK1 RNF144B SERTAD3 SMARCB1 SOHLH1 SPRED1 SUV39H1 TEPSIN TFIP11 TRIB3 TRIM23 TRIM27 TRIM42 TRIP6 UBXN11 USHBP1 WWTR1 ZBTB39 ZIM2 ZNF143 ZNF165 ZNF474 ZNF526 ZNF572 ZNF581 ZNF620 ZNF774 ZNF777 ZNF835 ZNRD2 ZRANB1	3 interacting genes: IL16 PPP1CB PRKG1
Entrez ID		3603	4660
HPRD ID		04329	04794
Ensembl ID		ENSG00000172349	ENSG00000077157
Uniprot IDs		A0A8C8KBU6 Q14005 Q9UME6	A0A994J7P4 E1CKY7 O60237
PDB IDs		1I16 1X6D 5FB8
Enriched GO Terms of Interacting Partners?		Protein Binding Myosin Phosphatase Regulator Activity NMDA Glutamate Receptor Activity NMDA Selective Glutamate Receptor Complex Excitatory Chemical Synaptic Transmission Ligand-gated Monoatomic Ion Channel Activity Zinc Ion Binding Identical Protein Binding Phosphatase Regulator Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Inward Rectifier Potassium Channel Activity Regulation Of Transcription By RNA Polymerase II Monoatomic Ion Channel Complex Glutamate-gated Calcium Ion Channel Activity Keratin Filament Regulation Of RNA Metabolic Process Regulation Of Neuronal Synaptic Plasticity Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Potassium Ion Transmembrane Transport Monoatomic Ion Channel Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Monoatomic Ion Transmembrane Transport Protein Kinase CK2 Complex Directional Locomotion Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Postsynaptic Membrane Potassium Ion Transport Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Ligand-gated Ion Channel Signaling Pathway Potassium Channel Activity Voltage-gated Potassium Channel Complex Synaptic Transmission, Glutamatergic Potassium Ion Import Across Plasma Membrane PDZ Domain Binding Regulation Of Primary Metabolic Process Protein Complex Oligomerization Stress Fiber A-type (transient Outward) Potassium Channel Activity Metal Ion Binding Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Regulation Of Synaptic Plasticity Transcription Corepressor Activity Metal Ion Transport Muscle Cell Development Long-term Synaptic Potentiation Regulation Of Postsynaptic Membrane Potential	Regulation Of Circadian Rhythm Myosin-light-chain-phosphatase Activity CGMP-dependent Protein Kinase Activity Negative Regulation Of Inositol Phosphate Biosynthetic Process Positive Regulation Of Neutrophil Activation Positive Regulation Of Interleukin-1 Alpha Production Myosin Phosphatase Activity PTW/PP1 Phosphatase Complex Mitogen-activated Protein Kinase P38 Binding Regulation Of Testosterone Biosynthetic Process Relaxation Of Smooth Muscle Negative Regulation Of Glutamate Secretion Relaxation Of Vascular Associated Smooth Muscle CD4 Receptor Binding Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Neutrophil Activation Focal Adhesion Induction Of Positive Chemotaxis Negative Regulation Of Amino Acid Transport CGMP Binding Negative Regulation Of Homotypic Cell-cell Adhesion Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Platelet Aggregation Positive Regulation Of Circadian Rhythm Relaxation Of Muscle Collateral Sprouting Negative Regulation Of Muscle Contraction Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Bone Growth Regulation Of Glutamate Secretion Negative Regulation Of Platelet Activation Regulation Of Ketone Biosynthetic Process Regulation Of Cell Activation Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Positive Chemotaxis Photoperiodism Entrainment Of Circadian Clock CGMP-mediated Signaling Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Platelet Aggregation Flemming Body Regulation Of Cell Adhesion Intracellular Signaling Cassette Positive Regulation Of Interleukin-12 Production Dendrite Development Cell Migration Calcium Channel Regulator Activity Regulation Of Vascular Permeability Organ Growth
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