PPP1R12B and PPP1CB

Number of citations of the paper that reports this interaction (PubMedID 9570949)
0

Data Source:
HPRD (in vitro)

		PPP1R12B	PPP1CB
Description		protein phosphatase 1 regulatory subunit 12B	protein phosphatase 1 catalytic subunit beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleoplasm Cytoplasm Cytosol Cytoskeleton Z Disc A Band	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Focal Adhesion Extracellular Exosome PTW/PP1 Phosphatase Complex
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Enzyme Activator Activity Myosin Phosphatase Regulator Activity Phosphatase Regulator Activity Protein Kinase Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Myosin Phosphatase Activity Protein Kinase Binding Metal Ion Binding Myosin-light-chain-phosphatase Activity
	Biological Process	Regulation Of Muscle Contraction Signal Transduction Neuron Projection Morphogenesis	MAPK Cascade Glycogen Metabolic Process Protein Dephosphorylation Regulation Of Cell Adhesion Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Rhythmic Process Cell Division
Pathways		RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs	Triglyceride catabolism Downregulation of TGF-beta receptor signaling Regulation of PLK1 Activity at G2/M Transition RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs RAF activation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling Maturation of hRSV A proteins Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs
Diseases
GWAS		Celiac disease ( 23936387) Chronic obstructive pulmonary disease ( 32824824) Coronary heart disease ( 24778558) Obesity-related traits ( 23251661) Sex ratio ( 26763874)	Body mass index ( 25673413) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Excessive sweating ( 29895819) Heel bone mineral density ( 28869591 30598549) Pre-treatment viral load in HIV-1 infection ( 31219150) Pure non-grapefruit juice consumption ( 31046077)
Interacting Genes		3 interacting genes: IL16 PPP1CB PRKG1	47 interacting genes: ACTN2 AURKA BRCA1 C14orf180 CHCHD3 CLK1 CLOCK CSNK2B CSRNP2 CYSRT1 DELEC1 FBXO7 H3-3A H3C1 HOXA2 KANK2 KIF23 LMTK2 MAPT MEOX2 NCOA1 NONO PHACTR3 PPP1R11 PPP1R12A PPP1R12B PPP1R12C PPP1R16A PPP1R27 PPP1R2B PPP1R2C PPP1R3A PPP1R3B PPP1R3C PPP1R7 PPP1R9A PPP2R5C PRKAR2A PTK2 RB1 RORC SPATC1L TLX1 TP53BP2 UBAC1 WBP11 ZFYVE9
Entrez ID		4660	5500
HPRD ID		04794	11792
Ensembl ID		ENSG00000077157	ENSG00000213639
Uniprot IDs		A0A994J7P4 E1CKY7 O60237	P62140 V9HW04
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Circadian Rhythm Myosin-light-chain-phosphatase Activity CGMP-dependent Protein Kinase Activity Negative Regulation Of Inositol Phosphate Biosynthetic Process Positive Regulation Of Neutrophil Activation Positive Regulation Of Interleukin-1 Alpha Production Myosin Phosphatase Activity PTW/PP1 Phosphatase Complex Mitogen-activated Protein Kinase P38 Binding Regulation Of Testosterone Biosynthetic Process Relaxation Of Smooth Muscle Negative Regulation Of Glutamate Secretion Relaxation Of Vascular Associated Smooth Muscle CD4 Receptor Binding Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Neutrophil Activation Focal Adhesion Induction Of Positive Chemotaxis Negative Regulation Of Amino Acid Transport CGMP Binding Negative Regulation Of Homotypic Cell-cell Adhesion Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Platelet Aggregation Positive Regulation Of Circadian Rhythm Relaxation Of Muscle Collateral Sprouting Negative Regulation Of Muscle Contraction Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Bone Growth Regulation Of Glutamate Secretion Negative Regulation Of Platelet Activation Regulation Of Ketone Biosynthetic Process Regulation Of Cell Activation Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Positive Chemotaxis Photoperiodism Entrainment Of Circadian Clock CGMP-mediated Signaling Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Platelet Aggregation Flemming Body Regulation Of Cell Adhesion Intracellular Signaling Cassette Positive Regulation Of Interleukin-12 Production Dendrite Development Cell Migration Calcium Channel Regulator Activity Regulation Of Vascular Permeability Organ Growth	Myosin Phosphatase Regulator Activity Protein Phosphatase Inhibitor Activity Phosphatase Regulator Activity Protein Phosphatase 1 Binding Glycogen Binding Protein Phosphatase Regulator Activity Protein Phosphatase Type 1 Complex Phosphatase Binding Enzyme Inhibitor Activity Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Regulation Of Glycogen Biosynthetic Process Stress Fiber Regulation Of Centromere Complex Assembly Regulation Of Glycogen Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Kinase Binding Centrosome Cycle Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Chromatin Cell Projection Organization Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle A Band Segment Specification Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle Process
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