IL12RB2 and IL12B

Number of citations of the paper that reports this interaction (PubMedID 11940489)
0

Data Source:
HPRD (in vivo)

		IL12RB2	IL12B
Description		interleukin 12 receptor subunit beta 2	interleukin 12B
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Cytosol Cell Surface Membrane Endosome Lumen Late Endosome Lumen Interleukin-12 Complex Interleukin-23 Complex
	Molecular Function	Cytokine Receptor Activity Coreceptor Activity Protein Kinase Binding Cytokine Binding	Cytokine Receptor Activity Cytokine Activity Cytokine Receptor Binding Interleukin-12 Receptor Binding Protein Binding Growth Factor Activity Interleukin-12 Alpha Subunit Binding Identical Protein Binding Protein-containing Complex Binding Interleukin-23 Receptor Binding Protein Heterodimerization Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Positive Regulation Of Type II Interferon Production Response To Cytokine Interleukin-12-mediated Signaling Pathway T-helper 1 Cell Differentiation	Regulation Of Cytokine Production Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Natural Killer Cell Activation Involved In Immune Response Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Population Proliferation Response To UV-B Cell Migration Natural Killer Cell Activation Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Tissue Remodeling Positive Regulation Of Smooth Muscle Cell Apoptotic Process Interleukin-12-mediated Signaling Pathway T-helper 1 Type Immune Response T-helper Cell Differentiation T Cell Proliferation Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation T Cell Activation Defense Response To Protozoan Positive Regulation Of Memory T Cell Differentiation T-helper 1 Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Oocyte Development Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Negative Regulation Of Protein Secretion Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Positive Regulation Of NK T Cell Activation Positive Regulation Of NK T Cell Proliferation Defense Response To Virus Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment
Pathways		Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling
Drugs			5-Mercapto-2-Nitro-Benzoic Acid Briakinumab Ustekinumab Ustekinumab humanized SMART Anti-IL-12 Antibody Tildrakizumab Risankizumab
Diseases			IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Behcet's disease ( 20622878 20622879) Blood protein levels ( 30072576) Crohn's disease ( 22412388 28067908) Crohn's disease or systemic sclerosis ( 32024964) Inflammatory bowel disease ( 23128233 28067908) Medication use (thyroid preparations) ( 31015401) Primary biliary cholangitis ( 20639880 21399635 26394269 19458352) Rheumatoid arthritis ( 32868391) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699) Systemic lupus erythematosus ( 28714469 33536424 26502338 19838195) Systemic sclerosis ( 29293537 31672989) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Type 2 diabetes (age of onset) ( 28060188) Ulcerative colitis ( 28067908)	Ankylosing spondylitis ( 23749187 21743469) Blood protein levels ( 30072576) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 32581322 17554261 20570966 30500874 21102463 28067908) Cutaneous psoriasis ( 26626624) Inflammatory bowel disease ( 26278503 23128233 28067908) interleukin 12 receptor subunit beta-1 levels ( 25147954) Leprosy ( 25642632 32421744) Multiple sclerosis ( 22190364 21833088) Pediatric autoimmune diseases ( 26301688) Primary biliary cholangitis ( 26394269) Psoriasis ( 25854761 25903422 19169254 23143594 19169255 20953190 20953188) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624 20953186) Response to taxane treatment (paclitaxel) ( 23006423) Sarcoidosis ( 26051272) Serum sulfate level ( 27412988) Takayasu arteritis ( 23830517 33308445) Tuberculosis susceptibility in HIV infection ( 26942285) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		5 interacting genes: IL12B IL12RB1 JAK2 SOCS3 STAT4	3 interacting genes: IL12A IL12RB1 IL12RB2
Entrez ID		3595	3593
HPRD ID		03383	01194
Ensembl ID		ENSG00000081985	ENSG00000113302
Uniprot IDs		A0A8Q3SIX0 B4DGA4 B7ZB60 Q99665	P29460
PDB IDs		8XRP 8YI7	1F42 1F45 3D85 3D87 3DUH 3HMX 3QWR 4GRW 5MJ3 5MJ4 5MXA 5MZV 5NJD 6UIB 6WDQ 8CR8 8OE4 8XRP 8YI7
Enriched GO Terms of Interacting Partners?		Interleukin-12-mediated Signaling Pathway T-helper 1 Cell Differentiation T-helper Cell Differentiation Interleukin-12 Receptor Binding T Cell Differentiation Involved In Immune Response CD4-positive, Alpha-beta T Cell Differentiation CD4-positive, Alpha-beta T Cell Activation Alpha-beta T Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT T Cell Activation Involved In Immune Response Cell Surface Receptor Signaling Pathway Via STAT Alpha-beta T Cell Activation Cytokine-mediated Signaling Pathway Positive Regulation Of T-helper 17 Type Immune Response Lymphocyte Activation Involved In Immune Response T Cell Differentiation Leukocyte Activation Involved In Immune Response Response To Cytokine Cell Activation Involved In Immune Response Response To Peptide Regulation Of T-helper 17 Type Immune Response Interleukin-12 Receptor Complex Lymphocyte Differentiation Interleukin-23 Receptor Complex T Cell Activation Mononuclear Cell Differentiation Positive Regulation Of Type II Interferon Production Positive Regulation Of Alpha-beta T Cell Activation Positive Regulation Of NK T Cell Proliferation Interleukin-23-mediated Signaling Pathway Leukocyte Differentiation Immune Effector Process Cellular Response To Cytokine Stimulus Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of T Cell Proliferation Positive Regulation Of NK T Cell Activation Positive Regulation Of Memory T Cell Differentiation Lymphocyte Activation Regulation Of Type II Interferon Production Regulation Of Alpha-beta T Cell Activation Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Adaptive Immune Response Regulation Of Memory T Cell Differentiation Positive Regulation Of Cell Fate Commitment Leukocyte Activation Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation	Interleukin-12-mediated Signaling Pathway T-helper 1 Cell Differentiation T-helper Cell Differentiation T Cell Differentiation Involved In Immune Response CD4-positive, Alpha-beta T Cell Differentiation CD4-positive, Alpha-beta T Cell Activation Alpha-beta T Cell Differentiation T Cell Activation Involved In Immune Response Positive Regulation Of Type II Interferon Production Interleukin-12 Receptor Binding Alpha-beta T Cell Activation Regulation Of Type II Interferon Production Lymphocyte Activation Involved In Immune Response Leukocyte Activation Involved In Immune Response T Cell Differentiation Cell Activation Involved In Immune Response Lymphocyte Differentiation T Cell Activation Mononuclear Cell Differentiation Leukocyte Differentiation Positive Regulation Of T Cell Mediated Cytotoxicity Immune Effector Process Cytokine-mediated Signaling Pathway Cytokine Binding Lymphocyte Activation Regulation Of T Cell Mediated Cytotoxicity Cytokine Receptor Activity Positive Regulation Of Cytokine Production Leukocyte Activation Coreceptor Activity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Cell Activation Positive Regulation Of Alpha-beta T Cell Activation Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Cytokine Production Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Population Proliferation Regulation Of Alpha-beta T Cell Activation Interleukin-12 Beta Subunit Binding Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Interleukin-27 Binding Positive Regulation Of Lymphocyte Mediated Immunity Interleukin-12 Receptor Activity Positive Regulation Of Adaptive Immune Response Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Leukocyte Proliferation Interleukin-12 Complex
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