IL12A and CXCL8

Number of citations of the paper that reports this interaction (PubMedID 16862120)
0

Data Source:
HPRD (in vitro)

		IL12A	CXCL8
Description		interleukin 12A	C-X-C motif chemokine ligand 8
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Late Endosome Lumen Interleukin-12 Complex	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Interleukin-12 Receptor Binding Protein Binding Growth Factor Activity Interleukin-12 Beta Subunit Binding Interleukin-27 Binding Protein Heterodimerization Activity	Cytokine Activity Interleukin-8 Receptor Binding Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Immune Response Response To Virus Response To UV-B Cell Migration Response To Lipopolysaccharide Negative Regulation Of Interleukin-17 Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Interleukin-12-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein T-helper 1 Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Negative Regulation Of Protein Secretion Defense Response To Gram-positive Bacterium Positive Regulation Of NK T Cell Activation Extrinsic Apoptotic Signaling Pathway Cellular Response To Virus Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Dendritic Cell Chemotaxis	Angiogenesis Response To Molecule Of Bacterial Origin Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-mediated Signaling Regulation Of Cell Adhesion Neutrophil Chemotaxis Receptor Internalization Killing Of Cells Of Another Organism Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Neutrophil Activation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Angiogenesis Embryonic Digestive Tract Development Induction Of Positive Chemotaxis Negative Regulation Of Cell Adhesion Molecule Production Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Neutrophil Chemotaxis Regulation Of Entry Of Bacterium Into Host Cell
Pathways		Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling	Senescence-Associated Secretory Phenotype (SASP) Peptide ligand-binding receptors Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress G alpha (i) signalling events Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling
Drugs			ABT-510 MDX-018 Rivanicline Oleandrin
Diseases
GWAS		Autoimmune traits (pleiotropy) ( 30572963) Behcet's disease ( 25799145 27548383 23291587) Bipolar disorder ( 31043756) Celiac disease ( 18311140 25920553 22057235 20190752) Limited cutaneous systemic scleroderma ( 24387989) Major depressive disorder ( 23377640) Multiple sclerosis ( 21833088 24076602 19525953) Primary biliary cholangitis ( 28425483 28062665 19458352 26394269 21399635 20639880) Primary biliary cirrhosis ( 22961000) Sjögren's syndrome ( 24097067) Systemic lupus erythematosus ( 26502338 27399966 28714469) Systemic sclerosis ( 24387989 31672989)	Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566)
Interacting Genes		7 interacting genes: CD28 CXCL8 EBI3 IL12B S100A6 S100P WASF1	23 interacting genes: ACKR1 ARFGAP3 BAG6 CCL2 CCL4 CCL5 CCL8 CTSL CXCR1 CXCR2 EP300 ERBB2 GNAI2 IL12A MMP14 MMP9 PF4 POMGNT1 SDC1 SGTA WASF1 ZFP36 ZNF598
Entrez ID		3592	3576
HPRD ID		01193	00909
Ensembl ID		ENSG00000168811	ENSG00000169429
Uniprot IDs		O60595 P29459	C9J4T6 P10145
PDB IDs		1F45 3HMX 8XRP 8YI7	1ICW 1IKL 1IKM 1IL8 1ILP 1ILQ 1QE6 1ROD 2IL8 3IL8 4XDX 5D14 5WDZ 6LFM 6LFO 6N2U 6WZM 6XMN 8IC0 8XWN 8XX6
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Alpha-beta T Cell Proliferation T Cell Proliferation Positive Regulation Of Alpha-beta T Cell Activation T-helper 1 Type Immune Response Positive Regulation Of T Cell Proliferation Lymphocyte Proliferation Regulation Of Alpha-beta T Cell Activation Mononuclear Cell Proliferation Leukocyte Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Leukocyte Proliferation Leukocyte Activation Regulation Of T Cell Proliferation Cell Activation Cytokine Activity Positive Regulation Of Interleukin-10 Production Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Humoral Immune Response Regulation Of Cell Population Proliferation Regulation Of Leukocyte Proliferation Regulation Of Mononuclear Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Cytokine Receptor Activity T Cell Activation Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Population Proliferation CD4-positive, Alpha-beta T Cell Activation Regulation Of Interleukin-10 Production Positive Regulation Of Immune System Process Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Type II Interferon Production Interleukin-12 Alpha Subunit Binding Regulation Of Viral Genome Replication Calcium-dependent Protein Binding Extracellular Region Regulation Of CD4-positive, Alpha-beta T Cell Activation Lymphocyte Activation Immune Response Positive Regulation Of Cell Adhesion Alpha-beta T Cell Activation Positive Regulation Of Gene Expression Regulation Of Cell-cell Adhesion Interleukin-8 Receptor Binding Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains	Chemokine-mediated Signaling Pathway Granulocyte Chemotaxis Granulocyte Migration Cell Surface Receptor Signaling Pathway Myeloid Leukocyte Migration Leukocyte Chemotaxis Cytokine-mediated Signaling Pathway Cell Migration Chemokine Activity Cell Chemotaxis Locomotion Eosinophil Chemotaxis Leukocyte Migration Eosinophil Migration C-C Chemokine Binding Cell Motility Positive Regulation Of Leukocyte Migration CCR Chemokine Receptor Binding Signal Transduction Chemotaxis Positive Regulation Of Mononuclear Cell Migration Inflammatory Response Mononuclear Cell Migration Cytokine Activity G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Migration Regulation Of Leukocyte Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Response To Stress Immune System Process Regulation Of Mononuclear Cell Migration Dendritic Cell Chemotaxis Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Regulation Of Immune System Process Antimicrobial Humoral Response Receptor-mediated Endocytosis Host-mediated Perturbation Of Viral Process Positive Regulation Of Immune System Process Monocyte Chemotaxis Defense Response Dendritic Cell Migration Regulation Of Lymphocyte Chemotaxis Interleukin-8 Binding Positive Regulation Of Macrophage Migration Regulation Of Apoptotic Process Positive Regulation Of Leukocyte Chemotaxis Host-mediated Perturbation Of Viral Transcription
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