CXCL8 and ZFP36

Number of citations of the paper that reports this interaction (PubMedID 30917308)
0

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		CXCL8	ZFP36
Description		C-X-C motif chemokine ligand 8	ZFP36 ring finger protein
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Exosome (RNase Complex) P-body Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule CCR4-NOT Complex Ribonucleoprotein Complex
	Molecular Function	Cytokine Activity Interleukin-8 Receptor Binding Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding	DNA Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding C-C Chemokine Binding Heat Shock Protein Binding MRNA 3'-UTR AU-rich Region Binding Protein-containing Complex Binding Metal Ion Binding RNA Polymerase Binding 14-3-3 Protein Binding Protein-RNA Sequence-specific Adaptor Activity
	Biological Process	Angiogenesis Response To Molecule Of Bacterial Origin Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-mediated Signaling Regulation Of Cell Adhesion Neutrophil Chemotaxis Receptor Internalization Killing Of Cells Of Another Organism Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Neutrophil Activation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Angiogenesis Embryonic Digestive Tract Development Induction Of Positive Chemotaxis Negative Regulation Of Cell Adhesion Molecule Production Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Neutrophil Chemotaxis Regulation Of Entry Of Bacterium Into Host Cell	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Response To Wounding Regulation Of Keratinocyte Proliferation Regulatory NcRNA-mediated Gene Silencing Nuclear-transcribed MRNA Catabolic Process, Deadenylation-independent Decay Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Viral Transcription MiRNA-mediated Gene Silencing By Inhibition Of Translation P38MAPK Cascade Response To Starvation Regulation Of MRNA Stability Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Fat Cell Differentiation Regulation Of Keratinocyte Differentiation Negative Regulation Of Erythrocyte Differentiation MRNA Transport Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening 3'-UTR-mediated MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Cellular Response To Lipopolysaccharide Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Regulation Of Keratinocyte Apoptotic Process Negative Regulation Of Polynucleotide Adenylyltransferase Activity Positive Regulation Of Intracellular MRNA Localization Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Positive Regulation Of MiRNA-mediated Gene Silencing
Pathways		Senescence-Associated Secretory Phenotype (SASP) Peptide ligand-binding receptors Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress G alpha (i) signalling events Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling	Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Drugs		ABT-510 MDX-018 Rivanicline Oleandrin
Diseases
GWAS		Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566)
Interacting Genes		23 interacting genes: ACKR1 ARFGAP3 BAG6 CCL2 CCL4 CCL5 CCL8 CTSL CXCR1 CXCR2 EP300 ERBB2 GNAI2 IL12A MMP14 MMP9 PF4 POMGNT1 SDC1 SGTA WASF1 ZFP36 ZNF598	29 interacting genes: APP ATG16L1 CCDC85B CDK6 CXCL8 DCP1B DHX36 DNAJB1 EDC3 EXOSC6 EXOSC8 FHL3 HMGB1 HOXC9 MAPK1 MAPKAPK2 MX1 NCL NUP214 PRMT2 RUNX1T1 SFN TNF UPF2 XRN1 YWHAB YWHAG YWHAH ZDHHC17
Entrez ID		3576	7538
HPRD ID		00909	01835
Ensembl ID		ENSG00000169429	ENSG00000128016
Uniprot IDs		C9J4T6 P10145	P26651
PDB IDs		1ICW 1IKL 1IKM 1IL8 1ILP 1ILQ 1QE6 1ROD 2IL8 3IL8 4XDX 5D14 5WDZ 6LFM 6LFO 6N2U 6WZM 6XMN 8IC0 8XWN 8XX6	4J8S
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Granulocyte Chemotaxis Granulocyte Migration Cell Surface Receptor Signaling Pathway Myeloid Leukocyte Migration Leukocyte Chemotaxis Cytokine-mediated Signaling Pathway Cell Migration Chemokine Activity Cell Chemotaxis Locomotion Eosinophil Chemotaxis Leukocyte Migration Eosinophil Migration C-C Chemokine Binding Cell Motility Positive Regulation Of Leukocyte Migration CCR Chemokine Receptor Binding Signal Transduction Chemotaxis Positive Regulation Of Mononuclear Cell Migration Inflammatory Response Mononuclear Cell Migration Cytokine Activity G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Migration Regulation Of Leukocyte Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Response To Stress Immune System Process Regulation Of Mononuclear Cell Migration Dendritic Cell Chemotaxis Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Regulation Of Immune System Process Antimicrobial Humoral Response Receptor-mediated Endocytosis Host-mediated Perturbation Of Viral Process Positive Regulation Of Immune System Process Monocyte Chemotaxis Defense Response Dendritic Cell Migration Regulation Of Lymphocyte Chemotaxis Interleukin-8 Binding Positive Regulation Of Macrophage Migration Regulation Of Apoptotic Process Positive Regulation Of Leukocyte Chemotaxis Host-mediated Perturbation Of Viral Transcription	Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear MRNA Surveillance Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of RNA Metabolic Process Identical Protein Binding MRNA Catabolic Process Response To Cytokine RRNA Catabolic Process Response To Peptide Nucleus Response To External Biotic Stimulus Positive Regulation Of Leukocyte Migration Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Protein Kinase C Inhibitor Activity Regulation Of RNA Biosynthetic Process Regulation Of Developmental Process Positive Regulation Of Gene Expression RNA Catabolic Process Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Regulation Of Cell Differentiation Positive Regulation Of Immune System Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Immune System Process Negative Regulation Of DNA-templated Transcription Cytoplasm Nuclear RNA Surveillance Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Regulation Of Leukocyte Migration Positive Regulation Of Biosynthetic Process Cytosol Regulation Of Viral Life Cycle RNA Surveillance Phosphoserine Residue Binding Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of DNA-templated Transcription Post-transcriptional Regulation Of Gene Expression Protein Sequestering Activity Regulation Of Translation
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