ZFP36 and NCL

Number of citations of the paper that reports this interaction (PubMedID 20221403)
78

Data Source:
BioGRID (two hybrid)

		ZFP36	NCL
Description		ZFP36 ring finger protein	nucleolin
Image
GO Annotations	Cellular Component	Exosome (RNase Complex) P-body Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule CCR4-NOT Complex Ribonucleoprotein Complex	Cornified Envelope Nucleus Nucleoplasm Spliceosomal Complex Chromosome Nucleolus Cytoplasm Plasma Membrane Cell Cortex Membrane Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Macropinosome Membrane Ribonucleoprotein Complex
	Molecular Function	DNA Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding C-C Chemokine Binding Heat Shock Protein Binding MRNA 3'-UTR AU-rich Region Binding Protein-containing Complex Binding Metal Ion Binding RNA Polymerase Binding 14-3-3 Protein Binding Protein-RNA Sequence-specific Adaptor Activity	Nucleic Acid Binding DNA Binding RNA Binding Protein Binding Telomeric DNA Binding PH Domain Binding Identical Protein Binding Insulin Receptor Substrate Binding DNA Topoisomerase Binding MRNA 5'-UTR Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Response To Wounding Regulation Of Keratinocyte Proliferation Regulatory NcRNA-mediated Gene Silencing Nuclear-transcribed MRNA Catabolic Process, Deadenylation-independent Decay Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Viral Transcription MiRNA-mediated Gene Silencing By Inhibition Of Translation P38MAPK Cascade Response To Starvation Regulation Of MRNA Stability Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Fat Cell Differentiation Regulation Of Keratinocyte Differentiation Negative Regulation Of Erythrocyte Differentiation MRNA Transport Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening 3'-UTR-mediated MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Cellular Response To Lipopolysaccharide Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Regulation Of Keratinocyte Apoptotic Process Negative Regulation Of Polynucleotide Adenylyltransferase Activity Positive Regulation Of Intracellular MRNA Localization Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Positive Regulation Of MiRNA-mediated Gene Silencing	Angiogenesis Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Metabolic Process Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Cellular Response To Leukemia Inhibitory Factor
Pathways		Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	Major pathway of rRNA processing in the nucleolus and cytosol Respiratory syncytial virus (RSV) attachment and entry
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder ( 23728934) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Eating disorders (purging via substances) ( 23568457) Hearing loss in noise exposure ( 26121033) Height ( 31562340) Hip index ( 34021172)
Interacting Genes		29 interacting genes: APP ATG16L1 CCDC85B CDK6 CXCL8 DCP1B DHX36 DNAJB1 EDC3 EXOSC6 EXOSC8 FHL3 HMGB1 HOXC9 MAPK1 MAPKAPK2 MX1 NCL NUP214 PRMT2 RUNX1T1 SFN TNF UPF2 XRN1 YWHAB YWHAG YWHAH ZDHHC17	61 interacting genes: ADAP1 ADAP2 BCL2 CD3E CDK1 CDKN2A CLK1 CSNK2A1 CSNK2A2 DANCR DUX4 ERG ESR1 ETS1 FMR1 GRB2 GZF1 GZMA H1-2 H2AC20 H2AX H2BC21 H3-4 HMGA1 IL7R ISG15 LINC01554 MDC1 MDK MDM2 MYB MYBL1 NBN NDRG1 NPM1 NR3C1 OGT PARP1 PPARGC1A PPM1D PRKCZ PRMT5 PTGS1 RAD51 RNF10 S100A11 SREK1 SRPK2 SSB STAU1 SUMO2 TERF2 TERT TOP1 TP53 VHL XRCC6 YWHAQ ZFP36 ZFP41 ZNF689
Entrez ID		7538	4691
HPRD ID		01835	01245
Ensembl ID		ENSG00000128016	ENSG00000115053
Uniprot IDs		P26651	B3KM80 P19338
PDB IDs		4J8S	2FC8 2FC9 2KRR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear MRNA Surveillance Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of RNA Metabolic Process Identical Protein Binding MRNA Catabolic Process Response To Cytokine RRNA Catabolic Process Response To Peptide Nucleus Response To External Biotic Stimulus Positive Regulation Of Leukocyte Migration Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Protein Kinase C Inhibitor Activity Regulation Of RNA Biosynthetic Process Regulation Of Developmental Process Positive Regulation Of Gene Expression RNA Catabolic Process Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Regulation Of Cell Differentiation Positive Regulation Of Immune System Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Immune System Process Negative Regulation Of DNA-templated Transcription Cytoplasm Nuclear RNA Surveillance Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Regulation Of Leukocyte Migration Positive Regulation Of Biosynthetic Process Cytosol Regulation Of Viral Life Cycle RNA Surveillance Phosphoserine Residue Binding Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of DNA-templated Transcription Post-transcriptional Regulation Of Gene Expression Protein Sequestering Activity Regulation Of Translation	Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Response To Stress Chromatin Organization Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm Negative Regulation Of Metabolic Process Chromosome DNA Damage Response Regulation Of Cell Population Proliferation Cellular Response To Stress Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Positive Regulation Of Biosynthetic Process Signal Transduction In Response To DNA Damage Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Protein Localization To Site Of Double-strand Break Protein Localization To Organelle DNA Binding Chromosome, Telomeric Region Regulation Of RNA Metabolic Process Chromatin Remodeling Response To Gamma Radiation Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Recombination Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Response To Ionizing Radiation Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Process DNA Metabolic Process Protein Localization To Chromosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Positive Regulation Of Gene Expression DNA Repair Negative Regulation Of DNA Metabolic Process Macromolecule Metabolic Process
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