IL6 and PTHLH

Number of citations of the paper that reports this interaction (PubMedID 12000745)
0

Data Source:
HPRD (in vitro)

		IL6	PTHLH
Description		interleukin 6	parathyroid hormone like hormone
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Interleukin-6 Receptor Complex	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Cytokine Activity Interleukin-6 Receptor Binding Protein Binding Growth Factor Activity Identical Protein Binding	Hormone Activity Protein Binding Peptide Hormone Receptor Binding
	Biological Process	Neutrophil Apoptotic Process Germinal Center B Cell Differentiation Hepatic Immune Response Neutrophil Mediated Immunity Monocyte Chemotaxis Positive Regulation Of Immunoglobulin Production Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Acute-phase Response Inflammatory Response Immune Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Vascular Endothelial Growth Factor Production Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Lipid Storage Response To Activity Cytokine-mediated Signaling Pathway Cell Differentiation Platelet Activation Endocrine Pancreas Development Neuron Projection Development Response To Peptidoglycan Negative Regulation Of Chemokine Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-21 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Maintenance Of Blood-brain Barrier Positive Regulation Of T Cell Proliferation Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Translation Regulation Of Angiogenesis Negative Regulation Of Bone Resorption Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Neurogenesis Regulation Of Insulin Secretion Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of B Cell Activation Regulation Of Protein Transport Positive Regulation Of Lymphocyte Activation Response To Glucocorticoid Defense Response To Virus Positive Regulation Of Glial Cell Proliferation T Follicular Helper Cell Differentiation Regulation Of Astrocyte Activation Neuron Cellular Homeostasis Glucagon Secretion Regulation Of Glucagon Secretion Interleukin-6-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide T-helper 17 Cell Lineage Commitment Hepatocyte Proliferation Positive Regulation Of Extracellular Matrix Disassembly Inflammatory Response To Wounding Liver Regeneration Cell Surface Receptor Signaling Pathway Via STAT Cellular Response To Virus Regulation Of Neuroinflammatory Response Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Platelet Aggregation Positive Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of MiRNA Transcription Regulation Of Microglial Cell Activation Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of T-helper 2 Cell Cytokine Production Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Interleukin-1-mediated Signaling Pathway Positive Regulation Of Type B Pancreatic Cell Apoptotic Process	Skeletal System Development Osteoblast Development Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Female Pregnancy Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Epidermis Development Regulation Of Gene Expression Bone Mineralization Regulation Of Chondrocyte Differentiation Negative Regulation Of Chondrocyte Differentiation CAMP Metabolic Process Negative Regulation Of Chondrocyte Development Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway
Pathways		Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by VENTX Post-translational protein phosphorylation ADORA2B mediated anti-inflammatory cytokines production CD163 mediating an anti-inflammatory response	Class B/2 (Secretin family receptors) G alpha (s) signalling events
Drugs		Ginseng YSIL6 VX-702 Atiprimod CRx-139 Andrographolide Siltuximab Polaprezinc Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Binimetinib Dilmapimod Olokizumab
Diseases		Graft-versus-host disease
GWAS		Asthma ( 32296059 31959851 31619474 30929738) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) C-reactive protein ( 21196492) C-reactive protein levels ( 30388399) Calcific aortic valve stenosis ( 32141789) Cerebrospinal fluid clusterin levels in APOEe4- carriers ( 26545630) Dialysis-related mortality ( 21546767) Fibrinogen ( 23969696) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Longevity ( 26912274) Longevity (age >90th survival percentile) ( 31413261) Longevity (age >99th survival percentile) ( 31413261) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758) Peripheral artery disease ( 31285632) Pulse pressure ( 30578418 30224653) Takayasu arteritis ( 25604533)	Asthma and hay fever ( 24388013) Blood protein levels ( 30072576) Bone mineral density (paediatric, lower limb) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Breast cancer ( 23535729 31757997 27117709 23535733) Breast cancer (estrogen-receptor negative) ( 27117709) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast size ( 27182965 22747683) Glaucoma (primary open-angle) ( 33627673) Height ( 31562340) Lumbar spine bone mineral density (trabecular) ( 27476799) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082) Male-pattern baldness ( 28196072) Ossification of the posterior longitudinal ligament of the spine ( 25064007) Osteoarthritis (hip) ( 30664745) Serum metabolite concentrations in chronic kidney disease ( 33838163)
Interacting Genes		10 interacting genes: - DNAH11 ELAVL1 HNRNPD IL6R IL6ST PTHLH SH3GL2 ZBTB16 ZC3H12A	7 interacting genes: ARRB1 CDK2 IL6 KLK3 KPNB1 MTDH PTH1R
Entrez ID		3569	5744
HPRD ID		00970	01348
Ensembl ID		ENSG00000136244	ENSG00000087494
Uniprot IDs		B4DNQ5 B4DVM1 B5MC21 B5MCZ3 P05231 Q75MH2	P12272 Q53XY9
PDB IDs		1ALU 1IL6 1P9M 2IL6 4CNI 4J4L 4NI7 4NI9 4O9H 4ZS7 5FUC 7NXZ 8D82 8QY5 8QY6 8YWQ 8YWR	1BZG 1M5N 3FFD 3H3G 7UZO 7UZP 7VVJ 8D51 8D52 8FLR 8HAF
Enriched GO Terms of Interacting Partners?		Interleukin-6 Binding Interleukin-6 Receptor Activity MRNA 3'-UTR AU-rich Region Binding Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Ciliary Neurotrophic Factor-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Interleukin-6 Receptor Binding MRNA Destabilization RNA Destabilization Positive Regulation Of Platelet Aggregation T-helper 17 Cell Lineage Commitment Positive Regulation Of MRNA Catabolic Process Interleukin-6-mediated Signaling Pathway 3'-UTR-mediated MRNA Destabilization T-helper Cell Lineage Commitment Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of MRNA Metabolic Process CD4-positive, Alpha-beta T Cell Lineage Commitment Response To Ether Alpha-beta T Cell Lineage Commitment Response To Salt CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Platelet Aggregation Regulation Of Cell-cell Adhesion T Cell Lineage Commitment Regulation Of MRNA Stability MiRNA Binding Regulation Of RNA Stability Negative Regulation Of Gene Expression Positive Regulation Of Gene Expression MRNA Binding Cytokine Receptor Activity Regulation Of Cell Activation Regulation Of Chondrocyte Differentiation Regulation Of Platelet Activation Positive Regulation Of Autophagosome Size Negative Regulation Of Macromolecule Biosynthetic Process Hepatocyte Dedifferentiation Cellular Response To Putrescine Ciliary Neurotrophic Factor Binding Proximal Portion Of Axoneme Positive Regulation Of Reactive Oxygen Species Metabolic Process MRNA Stabilization Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Biosynthetic Process	Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Vasculature Development Positive Regulation Of Macromolecule Metabolic Process Regulation Of Angiogenesis Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Glucagon Secretion Neutrophil Apoptotic Process Regulation Of Metabolic Process Angiotensin Receptor Binding Regulation Of Interleukin-8 Production Positive Regulation Of Intracellular Signal Transduction Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Positive Regulation Of Interleukin-21 Production Hepatic Immune Response Parathyroid Hormone Receptor Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Chromatin Organization Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Negative Regulation Of Primary MiRNA Processing Interleukin-6 Receptor Complex Positive Regulation Of Antibacterial Peptide Production Regulation Of Interleukin-6 Production X Chromosome Mitotic Chromosome Movement Towards Spindle Pole Ribosomal Protein Import Into Nucleus RNA Import Into Nucleus Positive Regulation Of Small Molecule Metabolic Process Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of Macromolecule Biosynthetic Process Regulation Of Antibacterial Peptide Production Positive Regulation Of Antimicrobial Peptide Production Regulation Of Gene Expression Positive Regulation Of Antimicrobial Humoral Response Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway
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