PTHLH

Description		parathyroid hormone like hormone
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Hormone Activity Protein Binding Peptide Hormone Receptor Binding
	Biological Process	Skeletal System Development Osteoblast Development Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Female Pregnancy Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Epidermis Development Regulation Of Gene Expression Bone Mineralization Regulation Of Chondrocyte Differentiation Negative Regulation Of Chondrocyte Differentiation CAMP Metabolic Process Negative Regulation Of Chondrocyte Development Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway
Pathways		Class B/2 (Secretin family receptors) G alpha (s) signalling events
Drugs
Diseases
GWAS		Asthma and hay fever ( 24388013) Blood protein levels ( 30072576) Bone mineral density (paediatric, lower limb) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Breast cancer ( 23535729 31757997 27117709 23535733) Breast cancer (estrogen-receptor negative) ( 27117709) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast size ( 27182965 22747683) Glaucoma (primary open-angle) ( 33627673) Height ( 31562340) Lumbar spine bone mineral density (trabecular) ( 27476799) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082) Male-pattern baldness ( 28196072) Ossification of the posterior longitudinal ligament of the spine ( 25064007) Osteoarthritis (hip) ( 30664745) Serum metabolite concentrations in chronic kidney disease ( 33838163)
Novel Interacting Genes		7 novel interacting genes: ARRB1 CDK2 IL6 KLK3 KPNB1 MTDH PTH1R
Interacting Genes		7 interacting genes: ARRB1 CDK2 IL6 KLK3 KPNB1 MTDH PTH1R
Entrez ID		5744
HPRD ID		01348
Ensembl ID		ENSG00000087494
Uniprot IDs		P12272 Q53XY9
PDB IDs		1BZG 1M5N 3FFD 3H3G 7UZO 7UZP 7VVJ 8D51 8D52 8FLR 8HAF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Vasculature Development Positive Regulation Of Macromolecule Metabolic Process Regulation Of Angiogenesis Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Glucagon Secretion Neutrophil Apoptotic Process Regulation Of Metabolic Process Angiotensin Receptor Binding Regulation Of Interleukin-8 Production Positive Regulation Of Intracellular Signal Transduction Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Positive Regulation Of Interleukin-21 Production Hepatic Immune Response Parathyroid Hormone Receptor Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Chromatin Organization Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Negative Regulation Of Primary MiRNA Processing Interleukin-6 Receptor Complex Positive Regulation Of Antibacterial Peptide Production Regulation Of Interleukin-6 Production X Chromosome Mitotic Chromosome Movement Towards Spindle Pole Ribosomal Protein Import Into Nucleus RNA Import Into Nucleus Positive Regulation Of Small Molecule Metabolic Process Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of Macromolecule Biosynthetic Process Regulation Of Antibacterial Peptide Production Positive Regulation Of Antimicrobial Peptide Production Regulation Of Gene Expression Positive Regulation Of Antimicrobial Humoral Response Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway
Tagcloud ?