IL1RN and COPS4

Number of citations of the paper that reports this interaction (PubMedID 15749898)
0

Data Source:
BioGRID (pull down)

		IL1RN	COPS4
Description		interleukin 1 receptor antagonist	COP9 signalosome subunit 4
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Vesicle Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Synaptic Vesicle COP9 Signalosome Nuclear Speck Cell Junction Cytoplasmic Vesicle Protein-containing Complex Synapse
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Interleukin-1, Type I Receptor Binding Interleukin-1, Type II Receptor Binding Interleukin-1 Receptor Antagonist Activity Protein Binding Interleukin-1 Type I Receptor Antagonist Activity Interleukin-1 Type II Receptor Antagonist Activity	Protein Binding DeNEDDylase Activity
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Lipid Metabolic Process Acute-phase Response Inflammatory Response Immune Response Signal Transduction Insulin Secretion Negative Regulation Of Heterotypic Cell-cell Adhesion Response To Glucocorticoid Negative Regulation Of Interleukin-1-mediated Signaling Pathway	Protein Deneddylation Protein Neddylation Regulation Of Protein Neddylation
Pathways		Interleukin-10 signaling Interleukin-1 signaling	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation RHOBTB1 GTPase cycle
Drugs		Rilonacept
Diseases		Graft-versus-host disease
GWAS		Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) C-reactive protein ( 22939635) C-reactive protein levels ( 33339817 29878111) Dysmenorrheic pain ( 27454463) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Granulocyte count ( 27863252) Interleukin-6 levels ( 33517400) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mitochondrial heteroplasmy measurement ( 33731350) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913) Red cell distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301) Spondylosis ( 33332786) Stroke ( 26089329) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252)	Metabolite levels ( 23823483)
Interacting Genes		6 interacting genes: COPS3 COPS4 IL1R1 IL1R2 POT1 TERF2IP	28 interacting genes: BRME1 CCDC85B CEBPA COPS2 COPS3 COPS5 COPS6 COPS7A COPS8 CUL5 DSCR9 FOS GPS1 HUNK IKBKB IL1RN KRT19 LCOR MBIP PCDHB12 PEX14 RAB18 RBX1 RCBTB2 TP53 UBQLN1 USHBP1 YWHAQ
Entrez ID		3557	51138
HPRD ID		00978	09888
Ensembl ID		ENSG00000136689	ENSG00000138663
Uniprot IDs		P18510	A0A0S2Z5H7 B3KM48 D6RAX7 Q9BT78
PDB IDs		1ILR 1ILT 1IRA 1IRP 2IRT	4D0P 4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F
Enriched GO Terms of Interacting Partners?		Interleukin-1 Binding Interleukin-1 Receptor Activity Shelterin Complex Regulation Of Interleukin-1-mediated Signaling Pathway Protein Deneddylation Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping Regulation Of Protein Neddylation Protein Neddylation Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening COP9 Signalosome Negative Regulation Of Telomere Maintenance Positive Regulation Of Interleukin-1-mediated Signaling Pathway Interleukin-1, Type II, Blocking Receptor Activity Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding DNA Biosynthetic Process Interleukin-1, Type I, Activating Receptor Activity Negative Regulation Of Interleukin-1 Alpha Production Regulation Of Cellular Response To Stress Protein Modification By Small Protein Removal Positive Regulation Of Telomeric Loop Disassembly Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Negative Regulation Of DNA Recombination At Telomere Regulation Of Protein Metabolic Process Telomere Organization Negative Regulation Of DNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Modification Process 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Regulation Of Double-strand Break Repair Telomeric D-loop Binding Telomere Assembly Chromosome, Telomeric Region Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Neutrophil Extravasation Regulation Of Metabolic Process Single-stranded Telomeric DNA Binding Regulation Of Neutrophil Extravasation DeNEDDylase Activity	Protein Deneddylation Protein Neddylation Regulation Of Protein Neddylation COP9 Signalosome Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Removal Protein Modification By Small Protein Conjugation Post-translational Protein Modification Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process COP9 Signalosome Assembly Protein Modification Process Intracellular Signaling Cassette Cytosol Regulation Of Primary Metabolic Process Negative Regulation Of Mitophagy Metal-dependent Deubiquitinase Activity Protein-containing Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cul5-RING Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Nucleoplasm Cytokine-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor DNA-templated Transcription Cellular Response To Stress Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Stem Cell Proliferation Nucleus Response To Tumor Necrosis Factor Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of RNA Metabolic Process Histone Deacetylase Binding Nuclear Matrix Macromolecule Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Metabolic Process Response To Glucocorticoid Cellular Response To Hypoxia Medium-term Memory Cellular Response To Prolactin Protein Metabolic Process Interleukin-1 Type I Receptor Antagonist Activity Interleukin-1 Type II Receptor Antagonist Activity Peroxisome Transport Along Microtubule
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