IL1RN and IL1R1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, x-ray crystallography)
HPRD (in vitro, in vivo)

		IL1RN	IL1R1
Description		interleukin 1 receptor antagonist	interleukin 1 receptor type 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Vesicle Extracellular Exosome	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Interleukin-1, Type I Receptor Binding Interleukin-1, Type II Receptor Binding Interleukin-1 Receptor Antagonist Activity Protein Binding Interleukin-1 Type I Receptor Antagonist Activity Interleukin-1 Type II Receptor Antagonist Activity	Protease Binding Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Interleukin-1 Receptor Activity Interleukin-1, Type I, Activating Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Hydrolase Activity Interleukin-1 Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Lipid Metabolic Process Acute-phase Response Inflammatory Response Immune Response Signal Transduction Insulin Secretion Negative Regulation Of Heterotypic Cell-cell Adhesion Response To Glucocorticoid Negative Regulation Of Interleukin-1-mediated Signaling Pathway	Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Smooth Muscle Adaptation Cytokine-mediated Signaling Pathway Positive Regulation Of Type II Interferon Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Inflammatory Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Positive Regulation Of Neutrophil Extravasation Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		Interleukin-10 signaling Interleukin-1 signaling	Interleukin-10 signaling Interleukin-1 signaling Potential therapeutics for SARS
Drugs		Rilonacept	Anakinra SD118 OMS-103HP Foreskin fibroblast (neonatal)
Diseases		Graft-versus-host disease
GWAS		Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) C-reactive protein ( 22939635) C-reactive protein levels ( 33339817 29878111) Dysmenorrheic pain ( 27454463) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Granulocyte count ( 27863252) Interleukin-6 levels ( 33517400) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mitochondrial heteroplasmy measurement ( 33731350) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913) Red cell distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301) Spondylosis ( 33332786) Stroke ( 26089329) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252)	Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Alanine aminotransferase levels ( 33547301) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29785011) Ankylosing spondylitis ( 23749187) Asthma ( 31959851 31619474 29785011 30929738 22561531) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Blood protein levels ( 30072576) C-reactive protein levels ( 30388399) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Inflammatory bowel disease ( 28067908 23128233) Primary biliary cholangitis ( 26394269) Serum protein levels (sST2) ( 23999434) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		6 interacting genes: COPS3 COPS4 IL1R1 IL1R2 POT1 TERF2IP	12 interacting genes: HYOU1 IL1A IL1B IL1F10 IL1RAP IL1RN IRAK2 MYD88 PIK3R1 SIGIRR TICAM2 TOLLIP
Entrez ID		3557	3554
HPRD ID		00978	00994
Ensembl ID		ENSG00000136689	ENSG00000115594
Uniprot IDs		P18510	B8ZZW4 P14778
PDB IDs		1ILR 1ILT 1IRA 1IRP 2IRT	1G0Y 1IRA 1ITB 4DEP 4GAF
Enriched GO Terms of Interacting Partners?		Interleukin-1 Binding Interleukin-1 Receptor Activity Shelterin Complex Regulation Of Interleukin-1-mediated Signaling Pathway Protein Deneddylation Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping Regulation Of Protein Neddylation Protein Neddylation Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening COP9 Signalosome Negative Regulation Of Telomere Maintenance Positive Regulation Of Interleukin-1-mediated Signaling Pathway Interleukin-1, Type II, Blocking Receptor Activity Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding DNA Biosynthetic Process Interleukin-1, Type I, Activating Receptor Activity Negative Regulation Of Interleukin-1 Alpha Production Regulation Of Cellular Response To Stress Protein Modification By Small Protein Removal Positive Regulation Of Telomeric Loop Disassembly Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Negative Regulation Of DNA Recombination At Telomere Regulation Of Protein Metabolic Process Telomere Organization Negative Regulation Of DNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Modification Process 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Regulation Of Double-strand Break Repair Telomeric D-loop Binding Telomere Assembly Chromosome, Telomeric Region Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Neutrophil Extravasation Regulation Of Metabolic Process Single-stranded Telomeric DNA Binding Regulation Of Neutrophil Extravasation DeNEDDylase Activity	Interleukin-1 Receptor Binding Inflammatory Response Interleukin-1-mediated Signaling Pathway Defense Response Cytokine-mediated Signaling Pathway Response To Stress Immune Response Acute-phase Response Immune System Process Cell Surface Receptor Signaling Pathway Cellular Response To Lipopolysaccharide Acute Inflammatory Response Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Cytokine Production Response To External Biotic Stimulus Positive Regulation Of Interleukin-6 Production Interleukin-1, Type I Receptor Binding Positive Regulation Of Cytokine Production Regulation Of Chemokine Production Response To Lipopolysaccharide Fever Generation Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Toll-like Receptor 4 Signaling Pathway Response To Molecule Of Bacterial Origin Signal Transduction Regulation Of Interleukin-6 Production Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Immature T Cell Proliferation In Thymus Molecular Adaptor Activity Cell Surface Pattern Recognition Receptor Signaling Pathway Toll-like Receptor Binding Response To Lipid Heat Generation Cellular Response To Lipid Toll Signaling Pathway Cytokine Activity Cellular Response To Oxygen-containing Compound Interleukin-33-mediated Signaling Pathway Negative Regulation Of Interleukin-1-mediated Signaling Pathway Negative Regulation Of Signal Transduction Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Chemokine Production Extrinsic Component Of Plasma Membrane Negative Regulation Of Cell Communication Negative Regulation Of Signaling Signaling Adaptor Activity
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