KCNT2 and DENND1B

		KCNT2	DENND1B
Description		potassium sodium-activated channel subfamily T member 2	DENN domain containing 1B
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytoplasm Cytosol Nuclear Speck Clathrin-coated Vesicle Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	Intracellular Sodium-activated Potassium Channel Activity Potassium Channel Activity Outward Rectifier Potassium Channel Activity Chloride-activated Potassium Channel Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane	Endocytosis Protein Transport Endocytic Recycling Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T-helper 2 Cell Cytokine Production
Pathways			RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age-related macular degeneration ( 23536807 23577725) Age-related macular degeneration (extreme sampling) ( 23577725) Body size at age 10 ( 32376654) Chronotype ( 30696823) High density lipoprotein cholesterol levels ( 34074324) Idiopathic dilated cardiomyopathy ( 29495422) Lung cancer in ever smokers ( 28604730) Photic sneeze reflex ( 27182965) Post bronchodilator FEV1 ( 26634245) Takayasu arteritis ( 25604533) Total ventricular volume ( 21116278) Waist-hip index ( 34021172)	Anxiety ( 33859377) Asthma ( 20032318) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin morphology ( 33593615) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coffee consumption (cups per day) ( 31837886) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 21102463 28067908) Depression ( 29700475) Eye morphology ( 33593615) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 27479909) Neutrophil percentage of white cells ( 32888494) Primary biliary cholangitis ( 21399635 26394269) Primary biliary cirrhosis ( 22961000) Serum protein levels (sST2) ( 23999434) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensities ( 32358547)
Interacting Genes		1 interacting genes: DENND1B	11 interacting genes: ARF1 ARF4 ARF5 ATP6V1G3 GLRX2 HOOK1 KCNT2 LNX1 RAB35 RBFOX2 ZBTB41
Entrez ID		343450	163486
HPRD ID		11584	13303
Ensembl ID		ENSG00000162687	ENSG00000213047
Uniprot IDs		A0A3B3IRL4 A9LNM6 Q6UVM3	Q6P3S1
PDB IDs			3TW8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of T Cell Cytokine Production Positive Regulation Of T-helper 2 Cell Cytokine Production Phosphatidylinositol Phosphate Binding Regulation Of Type 2 Immune Response Positive Regulation Of Type 2 Immune Response Regulation Of T Cell Cytokine Production Vesicle-mediated Transport To The Plasma Membrane Intracellular Membrane-bounded Organelle Clathrin-coated Vesicle T Cell Receptor Signaling Pathway Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of T Cell Mediated Immunity Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Antigen Receptor-mediated Signaling Pathway Endocytic Recycling Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Regulation Of Production Of Molecular Mediator Of Immune Response Guanyl-nucleotide Exchange Factor Activity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Positive Regulation Of Immune Effector Process Small GTPase Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Endosomal Transport	GTPase Activity GTP Binding Establishment Of Localization In Cell Vesicle-mediated Transport Protein Transport Intracellular Transport Mitotic Cleavage Furrow Ingression Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Arsenate Reductase (glutaredoxin) Activity Chloride-activated Potassium Channel Activity Intracellular Sodium-activated Potassium Channel Activity Establishment Of Protein Localization Cleavage Furrow Ingression Phospholipase D Activator Activity Glutathione Disulfide Oxidoreductase Activity Cellular Localization
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