DENND1B and ARF4

Number of citations of the paper that reports this interaction (PubMedID 33443570)
75

Data Source:
BioGRID (pull down)

		DENND1B	ARF4
Description		DENN domain containing 1B	ARF GTPase 4
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Nuclear Speck Clathrin-coated Vesicle Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Ruffle Membrane Dendritic Spine Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding Phosphatidylinositol Phosphate Binding	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding GTP Binding NAD+-protein-arginine ADP-ribosyltransferase Activity Phospholipase D Activator Activity
	Biological Process	Endocytosis Protein Transport Endocytic Recycling Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T-helper 2 Cell Cytokine Production	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Epidermal Growth Factor Receptor Signaling Pathway Learning Protein Transport Vesicle-mediated Transport Cell Migration Negative Regulation Of Apoptotic Process Apical Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Transcription By RNA Polymerase II Response To Axon Injury Regulation Of Synapse Organization Cilium Assembly Dendritic Spine Development Protein Localization To Cilium Regulation Of Postsynapse Organization Regulation Of Cilium Assembly Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		RAB GEFs exchange GTP for GDP on RABs	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs			Guanosine-5'-Diphosphate
Diseases
GWAS		Anxiety ( 33859377) Asthma ( 20032318) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin morphology ( 33593615) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coffee consumption (cups per day) ( 31837886) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 21102463 28067908) Depression ( 29700475) Eye morphology ( 33593615) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 27479909) Neutrophil percentage of white cells ( 32888494) Primary biliary cholangitis ( 21399635 26394269) Primary biliary cirrhosis ( 22961000) Serum protein levels (sST2) ( 23999434) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensities ( 32358547)
Interacting Genes		11 interacting genes: ARF1 ARF4 ARF5 ATP6V1G3 GLRX2 HOOK1 KCNT2 LNX1 RAB35 RBFOX2 ZBTB41	18 interacting genes: ADRB2 APBA1 APBA2 APBA3 COPS3 DENND1A DENND1B EGFR HNRNPD IKBKG ITIH1 PTEN RAB11FIP3 RCHY1 RHOA SDCBP2 SIRPA SUMO2
Entrez ID		163486	378
HPRD ID		13303	03107
Ensembl ID		ENSG00000213047	ENSG00000168374
Uniprot IDs		Q6P3S1	P18085
PDB IDs		3TW8	1Z6X
Enriched GO Terms of Interacting Partners?		GTPase Activity GTP Binding Establishment Of Localization In Cell Vesicle-mediated Transport Protein Transport Intracellular Transport Mitotic Cleavage Furrow Ingression Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Arsenate Reductase (glutaredoxin) Activity Chloride-activated Potassium Channel Activity Intracellular Sodium-activated Potassium Channel Activity Establishment Of Protein Localization Cleavage Furrow Ingression Phospholipase D Activator Activity Glutathione Disulfide Oxidoreductase Activity Cellular Localization	Dendritic Spine Amyloid-beta Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Size Positive Regulation Of Proteolysis Regulation Of Protein Metabolic Process Endocytic Recycling Regulation Of Macromolecule Metabolic Process In Utero Embryonic Development Chordate Embryonic Development Regulation Of Cell Communication Regulation Of Signaling Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Establishment Of Protein Localization Regulation Of Metabolic Process Chemical Synaptic Transmission Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Trans-synaptic Signaling Synaptic Signaling Regulation Of Protein Modification Process Vesicle-mediated Transport To The Plasma Membrane Phosphatidylinositol Phosphate Binding Cerebral Cortex Cell Migration Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cellular Localization Regulation Of Gene Expression Protein Transport Regulation Of Proteolysis Establishment Of Localization In Cell Protein Homodimerization Activity Cellular Response To Estradiol Stimulus Enzyme Binding Regulation Of Macromolecule Biosynthetic Process Response To Electrical Stimulus Positive Regulation Of Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Mini Excitatory Postsynaptic Potential Intracellular Transport Presynaptic Modulation Of Chemical Synaptic Transmission Locomotory Behavior
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?