IRF8 and CST1

		IRF8	CST1
Description		interferon regulatory factor 8	cystatin SN
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Extracellular Region Extracellular Space Cytoplasm Vesicle
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Plasmacytoid Dendritic Cell Differentiation Germinal Center B Cell Differentiation Follicular B Cell Differentiation Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Phagocytosis Autophagy Immune Response Response To Bacterium Myeloid Cell Differentiation Regulation Of Type I Interferon Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-12 Production Defense Response To Bacterium Defense Response To Protozoan Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Dendritic Cell Differentiation Defense Response To Other Organism	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste
Pathways		Interferon gamma signaling Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Behcet's disease ( 33393726) Chronic lymphocytic leukemia ( 21131588 24292274 28165464 23770605 26956414) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Diabetic retinopathy ( 21441570) Gestational age at birth (maternal effect) ( 27490719) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Inflammatory bowel disease ( 23128233) Limited cutaneous systemic scleroderma ( 29293537) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 23857890) Major depressive disorder x sex interaction ( 34099189) Monocyte count ( 27863252 32888494 23314186 28193307 29403010) Monocyte percentage of white cells ( 27863252 32888494) Multiple sclerosis ( 31604244 19525953 24076602 21833088) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 27863252 32888494) PR interval ( 32439900) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 24390342 23143596 22446963 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Severe insulin-deficient type 2 diabetes ( 34737425) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 28714469 27399966 26663301 26502338 33272962 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989 21779181) Systemic sclerosis (anti-centromere-positive) ( 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) ( 31794020) Ulcerative colitis ( 32072174 23511034)	Blood protein levels ( 30072576)
Interacting Genes		21 interacting genes: ATP2C2 COPS2 CST1 GAN IRF1 IRF2 IRF6 KIAA0513 MLC1 NFKB1 PLCG2 PPIG RELA SMURF2 SPI1 SPIRE2 TOP1 TRAF6 TRIM21 ZBTB17 ZDHHC7	8 interacting genes: APOE ASPH CSNK2B IER3IP1 IRF8 SGTA SYCE1L UBQLN2
Entrez ID		3394	1469
HPRD ID		03336	00460
Ensembl ID		ENSG00000140968	ENSG00000170373
Uniprot IDs		H3BRT4 Q02556	P01037
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-12 Production Transcription Cis-regulatory Region Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Canonical NF-kappaB Signal Transduction NF-kappaB P50/p65 Complex DNA-templated Transcription Regulation Of Innate Immune Response Response To Virus Negative Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Non-canonical NF-kappaB Signal Transduction Follicular B Cell Differentiation Lipopolysaccharide-mediated Signaling Pathway Regulation Of Type I Interferon Production Negative Regulation Of RNA Metabolic Process Defense Response To Virus Toll-like Receptor Signaling Pathway Transcription Coactivator Binding Regulation Of Cytokine Production Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Defense Response Cellular Response To Nicotine Positive Regulation Of Nucleobase-containing Compound Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of MiRNA Metabolic Process Defense Response To Tumor Cell Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Innate Immune Response Regulation Of Immune Response Cytokine-mediated Signaling Pathway Defense Response Antiviral Innate Immune Response Actinin Binding Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Response To Angiotensin Regulation Of MiRNA Metabolic Process Cellular Response To Interleukin-6 Positive Regulation Of Type I Interferon Production Sequence-specific DNA Binding Immune System Process Positive Regulation Of Defense Response Cellular Response To Lipid	Regulation Of Proteolysis Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of Phospholipid Efflux Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Metabolic Process Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Negative Regulation Of Endothelial Cell Migration Regulation Of Protein Metabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Positive Regulation Of Protein Transport Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Regulation Of Protein Transport Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle Positive Regulation Of Protein Localization Peptidyl-aspartic Acid 3-dioxygenase Activity Plasmacytoid Dendritic Cell Differentiation TRC Complex Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Extracellular Matrix Constituent Secretion Regulation Of Establishment Of Protein Localization Positive Regulation Of Catabolic Process Intermediate-density Lipoprotein Particle
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