IL2RG and SHB

Number of citations of the paper that reports this interaction (PubMedID 12200137)
0

Data Source:
HPRD (in vivo)

		IL2RG	SHB
Description		interleukin 2 receptor subunit gamma	SH2 domain containing adaptor protein B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Endosome Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Receptor Complex	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Cytokine Receptor Activity Interleukin-2 Receptor Activity Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Binding Coreceptor Activity Cytokine Binding Interleukin-2 Binding Interleukin-15 Receptor Activity	Phosphotyrosine Residue Binding Protein Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Mature B Cell Differentiation CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Immune System Process Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cellular Homeostasis Lymphocyte Differentiation B Cell Differentiation Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation T Cell Differentiation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Positive Regulation Of B Cell Differentiation Positive Regulation Of Phagocytosis	Angiogenesis Blood Vessel Development Apoptotic Process Signal Transduction Hemopoiesis Cell Differentiation B Cell Proliferation Positive Regulation Of T-helper Cell Differentiation Positive Regulation Of Mitotic Cell Cycle Blood Vessel Morphogenesis T Cell Receptor Signaling Pathway Hematopoietic Stem Cell Proliferation Negative Regulation Of Oocyte Maturation
Pathways		Interleukin-7 signaling Interleukin-7 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Interleukin receptor SHC signaling STAT3 nuclear events downstream of ALK signaling	VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway
Drugs		Denileukin diftitox Aldesleukin Resatorvid
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS			Brain structure ( 20171287) Chronotype ( 30696823) Loneliness (linear analysis) ( 27629369) Longevity (100 years and older) ( 33948810) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		27 interacting genes: AXL CAPNS1 ERRFI1 ICAM1 IL15 IL15RA IL2 IL2RB IL4 IL4R IL7 IL7R IL9R JAK1 JAK3 KRTAP10-3 KRTAP10-8 KRTAP5-7 NOTCH2NLA PTPRJ SHB SHC1 STAT1 STAT5A STK4 WWP1 WWP2	28 interacting genes: ABL1 AR CRK EGFR EPS8 ERBB2 ERBB3 ERBB4 FGFR1 GRAP2 GRB2 IL2RB IL2RG JAK1 JAK3 KDR KIT LAMTOR5 LAT LCP2 MET PDGFRA PIK3R1 PLCG1 SLC39A1 SRC VAV1 ZAP70
Entrez ID		3561	6461
HPRD ID		02391	02635
Ensembl ID		ENSG00000147168	ENSG00000107338
Uniprot IDs		H0Y8J6 P31785	Q15464
PDB IDs		2B5I 2ERJ 3BPL 3QAZ 3QB7 4GS7 5M5E 6OEL 7S2R 8ENT 8EPA 9JQT
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Positive Regulation Of Lymphocyte Differentiation Regulation Of Lymphocyte Differentiation Lymphocyte Activation Cell Surface Receptor Signaling Pathway Interleukin-4-mediated Signaling Pathway Positive Regulation Of Leukocyte Differentiation Interleukin-9-mediated Signaling Pathway Leukocyte Activation Regulation Of Hemopoiesis Lymphocyte Differentiation Cell Activation Interleukin-2-mediated Signaling Pathway Positive Regulation Of Cell Activation Regulation Of T Cell Differentiation Cell Surface Receptor Signaling Pathway Via STAT Mononuclear Cell Differentiation Positive Regulation Of Lymphocyte Activation Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Leukocyte Differentiation Regulation Of Multicellular Organismal Development Positive Regulation Of Cell Development Positive Regulation Of T Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Development Positive Regulation Of Cell Differentiation Regulation Of Cell-cell Adhesion Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Activation Regulation Of Natural Killer Cell Differentiation Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Signal Transduction Cytokine Receptor Activity Regulation Of T-helper Cell Differentiation Positive Regulation Of Immune System Process B Cell Activation Regulation Of Cell Differentiation Regulation Of Cytokine Production Immune System Process Natural Killer Cell Differentiation Regulation Of Immune System Process Natural Killer Cell Activation	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Signal Transduction Positive Regulation Of MAPK Cascade Receptor Complex Protein Kinase Activity Peptidyl-tyrosine Phosphorylation Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Kinase Activity Plasma Membrane ERBB Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Signal Transduction Cell Activation Intracellular Signaling Cassette Cell Migration Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Leukocyte Activation Regulation Of Multicellular Organismal Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Phosphorylation Cell Differentiation Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Protein Phosphorylation Regulation Of Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Phosphorylation Cell Motility Cellular Developmental Process Phosphorylation ERBB2 Signaling Pathway Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process T Cell Activation Positive Regulation Of Epithelial Cell Proliferation
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