DNAJB2 and NEDD8

Number of citations of the paper that reports this interaction (PubMedID 33665565)
71

Data Source:
BioGRID (pull down)

		DNAJB2	NEDD8
Description		DnaJ heat shock protein family (Hsp40) member B2	NEDD8 ubiquitin like modifier
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GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Inclusion Body Nuclear Membrane Perinuclear Region Of Cytoplasm Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	ATPase Activator Activity Protein Binding Hsp70 Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Unfolded Protein Binding Protein-folding Chaperone Binding Proteasome Binding Protein Serine/threonine Kinase Binding Ubiquitin-modified Protein Reader Activity Protein Transporter Activity	Protein Binding Protein Tag Activity Ubiquitin Protein Ligase Binding
	Biological Process	Protein Folding Response To Unfolded Protein Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Growth Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of ATP-dependent Activity Regulation Of Protein Localization ERAD Pathway Protein Refolding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neuron Cellular Homeostasis Negative Regulation Of Inclusion Body Assembly Negative Regulation Of Protein Deubiquitination Regulation Of Protein Folding	Regulation Of Transcription By RNA Polymerase II Proteolysis Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Localization Anatomical Structure Morphogenesis Protein Ubiquitination Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Protein Modification Process Protein Neddylation Cellular Response To Camptothecin Regulation Of Postsynapse Assembly
Pathways			TGF-beta receptor signaling activates SMADs UCH proteinases Cargo recognition for clathrin-mediated endocytosis Neddylation Iron uptake and transport
Drugs
Diseases
GWAS			Mean corpuscular volume ( 29403010) Systolic blood pressure (cigarette smoking interaction) ( 26752167)
Interacting Genes		11 interacting genes: CSNK2A1 FBXO25 HSPA4 MAP3K1 NEDD8 RPS27A SMAD4 UBA52 UBC UBQLN1 VPS26C	72 interacting genes: AHR ANKRD13D ARIH2 ATE1 ATXN3 BAG3 CBLB CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B DNAJA2 DNAJB2 DNMT3B EIF3I FAF1 GARS1 GHR GRN GTF3C3 HDAC6 HGS HIF1A HSPA1B HSPA4 HSPA4L HSPA8 HSPA9 HSPH1 HYPK KLHDC2 N4BP1 NAE1 NSFL1C NUB1 NXPH2 OLFML2B OTUB1 OTUB2 OTUD5 OTUD6B PARP1 PCNA POLI PPP1CA PRKN PSMA6 PSMD4 PTK2 RAD23A SENP8 SET SIRT1 SMURF1 SQSTM1 TOLLIP TP53 TUBB4B UBA2 UBA3 UBE2K UBE2M UBL7 UBQLN1 UBXN7 UCHL1 UCHL3 YAF2
Entrez ID		3300	4738
HPRD ID		07249	04412
Ensembl ID		ENSG00000135924	ENSG00000129559
Uniprot IDs		P25686	Q15843
PDB IDs		2LGW	1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2N7K 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP 4P5O 6R7F 6R7I 6TTU 7B5L 7B5N 7ONI 8B3G 8B3I 8CAF 8H38 8Q7H 8RX0 8WQC 8WQG 8WZN 8WZO
Enriched GO Terms of Interacting Partners?		Protein Tag Activity Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Endocytic Vesicle Membrane Protein Ubiquitination Aggrephagy Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Protein Metabolic Process Post-translational Protein Modification Vesicle Protein Modification Process Mitochondrial Outer Membrane Nucleus Macromolecule Metabolic Process Catabolic Process Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Proteolysis Negative Regulation Of Store-operated Calcium Channel Activity Endosome Membrane Cytosol Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis Protein Kinase CK2 Complex Regulation Of Protein Catabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Proteolysis Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Metanephric Mesenchyme Morphogenesis Cytosolic Ribosome Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Protein Catabolic Process Cytoplasmic Translation Positive Regulation Of Aggrephagy Sulfate Binding Endocardial Cell Differentiation Cellular Response To Camptothecin Macroautophagy SMAD Protein Complex Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Atrioventricular Valve Formation Formation Of Anatomical Boundary Mesendoderm Development Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin Protein Ligase Binding Proteasomal Protein Catabolic Process Ubiquitin Binding Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Protein Modification Process Protein Modification By Small Protein Conjugation Cytosol Positive Regulation Of Catabolic Process Protein Modification By Small Protein Removal Regulation Of Protein Metabolic Process Nucleoplasm Regulation Of Post-translational Protein Modification Regulation Of Proteolysis Protein Ubiquitination Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Deubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Nucleus Protein Polyubiquitination Protein Targeting To Vacuole Involved In Autophagy Cullin-RING Ubiquitin Ligase Complex DeNEDDylase Activity Aggresome ATP-dependent Protein Folding Chaperone Polyubiquitin Modification-dependent Protein Binding Regulation Of Proteasomal Protein Catabolic Process Protein Folding Response To Stress Protein Neddylation Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Stability Positive Regulation Of Metabolic Process Cellular Response To Stress Cytoplasm
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