HOXD8 and PFDN1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		HOXD8	PFDN1
Description		homeobox D8	prefoldin subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Cytoplasm Prefoldin Complex Protein-containing Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Axis Specification, Embryo Anterior/posterior Pattern Specification Positive Regulation Of Transcription By RNA Polymerase II Skeletal System Morphogenesis	Protein Folding Negative Regulation Of Amyloid Fibril Formation
Pathways			Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Chronic kidney disease ( 31152163) Estimated glomerular filtration rate ( 30604766 31015462 31152163) Glomerular filtration rate (creatinine) ( 28452372) Male-pattern baldness ( 28196072) Urate levels ( 31578528)	Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Reaction time ( 29844566)
Interacting Genes		9 interacting genes: ANXA7 BAIAP2 CDKN1A DYNC1I2 HMGB1 LDLRAP1 NCK2 PFDN1 RCC1	55 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEBPA CEP126 CHGA DCTN1 DEFA1 DMAP1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235
Entrez ID		3234	5201
HPRD ID		00868	05357
Ensembl ID		ENSG00000175879	ENSG00000113068
Uniprot IDs		A0A0A0MSX5 P13378	O60925
PDB IDs			6NR8 6NR9 6NRB 6NRC 6NRD 7WU7
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Cytoskeletal Anchor Activity Positive Regulation Of Leukocyte Proliferation Signaling Receptor Complex Adaptor Activity Vesicle Membrane Cytoplasm Regulation Of Leukocyte Proliferation Regulation Of Mononuclear Cell Proliferation Phosphotyrosine Residue Binding Positive Regulation Of Actin Filament Polymerization Phosphatidylserine Binding Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell Population Proliferation PCNA-p21 Complex Cell Cycle G1/S Phase Transition Negative Regulation Of Cardiac Muscle Tissue Regeneration G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Activation Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Myeloid Progenitor Cell Differentiation Negative Regulation Of Apoptotic Cell Clearance Regulation Of Supramolecular Fiber Organization Amyloid-beta Binding Positive Regulation Of Protein Polymerization Signaling Adaptor Activity Scaffold Protein Binding Dendritic Spine Cytoplasm Neuron Projection Branch Point Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Receptor-mediated Endocytosis Involved In Cholesterol Transport Regulation Of Protein-containing Complex Assembly Positive Regulation Of T Cell Proliferation C-X-C Chemokine Binding Alphav-beta3 Integrin-HMGB1 Complex T-helper 1 Cell Activation Positive Regulation Of Mismatch Repair Positive Regulation Of Intracellular Cholesterol Transport Regulation Of Lymphocyte Activation Cellular Response To Cell-matrix Adhesion Regulation Of Mismatch Repair Plasmacytoid Dendritic Cell Activation Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress	Positive Regulation Of Microtubule Nucleation Structural Constituent Of Cytoskeleton Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Microtubule Nucleation Nuclear Matrix Positive Regulation Of DNA Recombination NuA4 Histone Acetyltransferase Complex Regulation Of Cell Cycle Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of Double-strand Break Repair Intracellular Protein Localization Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Glutamate Receptor Binding Regulation Of Cellular Component Organization
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