HOXD4 and PBX1

Number of citations of the paper that reports this interaction (PubMedID 10523646)
65

Data Source:
HPRD (in vitro, in vivo)

		HOXD4	PBX1
Description		homeobox D4	PBX homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cell Junction	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding Transcription Corepressor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Anterior/posterior Pattern Specification Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Embryonic Skeletal System Morphogenesis Stem Cell Differentiation	G2/M Transition Of Mitotic Cell Cycle Eye Development Urogenital System Development Branching Involved In Ureteric Bud Morphogenesis Natural Killer Cell Differentiation Regulation Of DNA-templated Transcription Steroid Biosynthetic Process Brain Development Sex Differentiation Cell Population Proliferation Animal Organ Morphogenesis Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Regulation Of Ossification Adrenal Gland Development Embryonic Limb Morphogenesis Embryonic Hemopoiesis Regulation Of Cell Population Proliferation Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Thymus Development Embryonic Organ Development Neuron Development Embryonic Skeletal System Development Stem Cell Proliferation Positive Regulation Of Stem Cell Proliferation
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	Transcriptional regulation of pluripotent stem cells Activation of anterior HOX genes in hindbrain development during early embryogenesis NOTCH3 Intracellular Domain Regulates Transcription
Drugs
Diseases			Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Estimated glomerular filtration rate ( 31015462) Male-pattern baldness ( 28196072) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Pelvic organ prolapse (moderate/severe) ( 26545240)	A body shape index ( 34021172) Asthma ( 29273806) Breast cancer (prognosis) ( 23319801) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Early-onset Parkinson's disease ( 28256260) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 20966902) High myopia ( 33830181) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Pre-treatment viral load in HIV-1 infection ( 31219150) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Smoking status (current vs never) ( 33082346) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		21 interacting genes: ASB8 CNOT7 CREBBP DEDD EP300 ETV4 FANCL HIPK1 HNRNPAB HOXB13 MEIS1 PBX1 PBX4 RNPS1 RXRG SNAI1 TIGD4 XRCC6 ZBTB32 ZMYND11 ZSCAN18	32 interacting genes: BRMS1L CDCA7L CREBBP EFHC1 FAM90A1 HOXA10 HOXA5 HOXA9 HOXB1 HOXB5 HOXB7 HOXB8 HOXC5 HOXC8 HOXD10 HOXD4 HOXD9 KAT2A MDM2 MEIS1 MEIS2 MYH10 NEDD4L NR3C1 PAX6 PBX2 PDX1 PIN1 PKNOX1 POU2F1 SMARCD3 UBC
Entrez ID		3233	5087
HPRD ID		00864	08889
Ensembl ID		ENSG00000170166	ENSG00000185630
Uniprot IDs		P09016	A8K5V0 P40424 Q53YC7
PDB IDs			1B72 1PUF
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Chromatin DNA Binding Nucleus Negative Regulation Of RNA Metabolic Process Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone H3K27 Acetyltransferase Activity Positive Regulation Of RNA Metabolic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Eye Development Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm Animal Organ Morphogenesis Sensory Organ Development Hemopoiesis Negative Regulation Of Transcription By RNA Polymerase I Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Damaged DNA Binding N-terminal Protein Amino Acid Acetylation Positive Regulation Of Biosynthetic Process Pattern Specification Process Peptidyl-lysine Acetylation Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Response To Heat Definitive Hemopoiesis	Pattern Specification Process Chromatin Regionalization Anterior/posterior Pattern Specification Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Animal Organ Morphogenesis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific Double-stranded DNA Binding Anatomical Structure Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Skeletal System Morphogenesis Embryonic Morphogenesis Regulation Of RNA Metabolic Process Embryonic Organ Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Embryonic Skeletal System Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression DNA Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nucleus Nucleoplasm Animal Organ Development Regulation Of Metabolic Process Proximal/distal Pattern Formation Developmental Process Embryonic Skeletal System Development Skeletal System Development Sequence-specific DNA Binding Chromatin Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Cellular Developmental Process Embryonic Limb Morphogenesis Gland Development Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Myeloid Cell Differentiation
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