PBX1 and POU2F1

Number of citations of the paper that reports this interaction (PubMedID 15138251)
61

Data Source:
BioGRID (pull down)

		PBX1	POU2F1
Description		PBX homeobox 1	POU class 2 homeobox 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding Transcription Corepressor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Eye Development Urogenital System Development Branching Involved In Ureteric Bud Morphogenesis Natural Killer Cell Differentiation Regulation Of DNA-templated Transcription Steroid Biosynthetic Process Brain Development Sex Differentiation Cell Population Proliferation Animal Organ Morphogenesis Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Regulation Of Ossification Adrenal Gland Development Embryonic Limb Morphogenesis Embryonic Hemopoiesis Regulation Of Cell Population Proliferation Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Thymus Development Embryonic Organ Development Neuron Development Embryonic Skeletal System Development Stem Cell Proliferation Positive Regulation Of Stem Cell Proliferation	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MiRNA Transcription
Pathways		Transcriptional regulation of pluripotent stem cells Activation of anterior HOX genes in hindbrain development during early embryogenesis NOTCH3 Intracellular Domain Regulates Transcription	Interleukin-4 and Interleukin-13 signaling RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter Estrogen-dependent gene expression
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		A body shape index ( 34021172) Asthma ( 29273806) Breast cancer (prognosis) ( 23319801) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Early-onset Parkinson's disease ( 28256260) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 20966902) High myopia ( 33830181) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Pre-treatment viral load in HIV-1 infection ( 31219150) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Smoking status (current vs never) ( 33082346) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Asthma ( 31619474 31959851) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Diastolic blood pressure ( 30224653) Liver enzyme levels ( 18940312) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		32 interacting genes: BRMS1L CDCA7L CREBBP EFHC1 FAM90A1 HOXA10 HOXA5 HOXA9 HOXB1 HOXB5 HOXB7 HOXB8 HOXC5 HOXC8 HOXD10 HOXD4 HOXD9 KAT2A MDM2 MEIS1 MEIS2 MYH10 NEDD4L NR3C1 PAX6 PBX2 PDX1 PIN1 PKNOX1 POU2F1 SMARCD3 UBC	67 interacting genes: APP AR ARPC3 ARRB1 BARD1 BRCA1 CEBPE CREB1 CREM ESR1 FDXR HCFC1 HIVEP1 HMGA1 HMGB2 HNF1A HOXB13 HOXC9 IRF9 LIFR MLLT10 MNAT1 MSX1 NCOR2 NFYA NPAT NR3C1 PARP1 PBX1 PGR PKNOX1 PLK3 POGZ POU2AF1 POU6F2 PPIP5K2 PRKACA PRKDC PRR20B PRR20C PRR20D PRR20E RARA RELA RXRA SNAPC4 SNIP1 SNX24 SOX2 SP1 SP4 STAT5A STAT5B STOX1 TBP THRA TLE4 TLE5 TLX2 TNF TXNRD1 UBE2I VDR XRCC6 ZC3H10 ZFHX3 ZMYM6
Entrez ID		5087	5451
HPRD ID		08889	01250
Ensembl ID		ENSG00000185630	ENSG00000143190
Uniprot IDs		A8K5V0 P40424 Q53YC7	A0A8A2IE78 P14859
PDB IDs		1B72 1PUF	1CQT 1E3O 1GT0 1HF0 1O4X 1OCT 1POG 1POU
Enriched GO Terms of Interacting Partners?		Pattern Specification Process Chromatin Regionalization Anterior/posterior Pattern Specification Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Animal Organ Morphogenesis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific Double-stranded DNA Binding Anatomical Structure Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Skeletal System Morphogenesis Embryonic Morphogenesis Regulation Of RNA Metabolic Process Embryonic Organ Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Embryonic Skeletal System Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression DNA Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nucleus Nucleoplasm Animal Organ Development Regulation Of Metabolic Process Proximal/distal Pattern Formation Developmental Process Embryonic Skeletal System Development Skeletal System Development Sequence-specific DNA Binding Chromatin Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Cellular Developmental Process Embryonic Limb Morphogenesis Gland Development Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Myeloid Cell Differentiation	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Nucleus Positive Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Regulation Of Metabolic Process Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Metabolic Process Enzyme Binding Sequence-specific Double-stranded DNA Binding Nuclear Receptor Activity Gland Development Nucleobase-containing Compound Biosynthetic Process Nucleic Acid Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Rhythmic Process Regulation Of MiRNA Transcription
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