HNRNPAB and DEDD2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		HNRNPAB	DEDD2
Description		heterogeneous nuclear ribonucleoprotein A/B	death effector domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Dendrite Protein-containing Complex MRNA Editing Complex Neuronal Ribonucleoprotein Granule RNA Polymerase II Transcription Regulator Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Protein Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Epithelial To Mesenchymal Transition Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process MRNA Modification Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Cellular Localization Cellular Response To Amino Acid Stimulus Chromosomal 5-methylcytosine DNA Demethylation Pathway Regulation Of Intracellular MRNA Localization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	RNA Processing Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors RRNA Catabolic Process Cellular Homeostasis Apoptotic Nuclear Changes Intracellular Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Immature fraction of reticulocytes ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Meat-related diet ( 32066663)
Interacting Genes		25 interacting genes: ACTB CDC42 CEBPA DBN1 DEDD2 ELAVL2 ERG GADD45G H3-4 H3C1 HMGA1 HOXC13 HOXD4 IL7R OGT POLR3D PROP1 PTBP1 PTBP2 PTEN RBFOX2 SYNCRIP TP63 USP19 YWHAG	12 interacting genes: ATG16L1 CASP10 CASP8 CDCA7L CDK6 CFLAR DEDD GTF3C3 HNRNPAB NR2E3 RBFOX2 RHOXF2
Entrez ID		3182	162989
HPRD ID		04067	10868
Ensembl ID		ENSG00000197451	ENSG00000160570
Uniprot IDs		Q99729	Q8WXF8
PDB IDs		3S7R
Enriched GO Terms of Interacting Partners?		Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Nucleoplasm Nucleus Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Morphogenesis Of A Polarized Epithelium DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Differentiation Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process DNA Binding Developmental Process Chromatin Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Stem Cell Population Maintenance Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Regulation Of Cell Differentiation Structural Constituent Of Chromatin Positive Regulation Of Signal Transduction Regulation Of Developmental Process Negative Regulation Of Developmental Process Dendritic Spine Morphogenesis Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Polarized Epithelial Cell Differentiation Negative Regulation Of Cellular Senescence Regulation Of Cell Cycle	Ripoptosome CD95 Death-inducing Signaling Complex Death Effector Domain Binding Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Death-inducing Signaling Complex Cysteine-type Endopeptidase Activity Positive Regulation Of Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Death Receptor Binding Positive Regulation Of Execution Phase Of Apoptosis Cysteine-type Peptidase Activity Execution Phase Of Apoptosis Regulation Of Necroptotic Process Regulation Of Programmed Necrotic Cell Death Macrophage Differentiation Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Neuron Apoptotic Process Cyclin D2-CDK6 Complex Vacuole-isolation Membrane Contact Site Regulation Of Metabolic Process Positive Regulation Of Gene Expression Mononuclear Cell Differentiation Apoptotic Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Skeletal Myofibril Assembly Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway C-terminal Protein Lipidation Developmental Process Protein-containing Complex Binding Negative Regulation Of RNA Metabolic Process Leukocyte Differentiation Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Autophagosome Assembly Negative Regulation Of Myoblast Fusion Negative Stranded Viral RNA Replication Autophagosome Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Apoptotic Process Response To Estradiol Negative Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Editing Complex Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Negative Regulation Of Dendrite Extension
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