FOXA3 and TLE2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		FOXA3	TLE2
Description		forkhead box A3	TLE family member 2, transcriptional corepressor
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Actin Cytoskeleton	Extracellular Space Nucleus Nucleoplasm Transcription Regulator Complex Focal Adhesion Nuclear Body
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Protein Binding
	Biological Process	Intracellular Glucose Homeostasis Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Spermatogenesis Cellular Response To Starvation Anatomical Structure Morphogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Homeostasis	Regulation Of DNA-templated Transcription Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Regulation of gene expression in beta cells	Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes
Drugs
Diseases
GWAS		Asthma ( 31959851 32296059) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		6 interacting genes: ALX4 HMGB1 MET PPARA TLE1 TLE2	16 interacting genes: BARHL1 EMX2 FOXA3 H3-3A HES1 HMGB1 LEF1 MSX1 MSX2 PAX9 PRDM1 RUNX1 TLE1 TLX3 UTY VENTX
Entrez ID		3171	7089
HPRD ID		03802	03025
Ensembl ID		ENSG00000170608	ENSG00000065717
Uniprot IDs		P55318	K7EMK7 Q04725
PDB IDs		1VTN
Enriched GO Terms of Interacting Partners?		Transcription Corepressor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Programmed Cell Death DNA-binding Transcription Factor Binding Regulation Of RNA Metabolic Process Transcription Regulator Complex Positive Regulation Of Glucose Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Chemotaxis Positive Regulation Of Binding Regulation Of Carbohydrate Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Animal Organ Development Negative Regulation Of RNA Biosynthetic Process Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Regulation Of Gene Expression Regulation Of Glucose Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Growth Factor Receptor Activity Negative Regulation Of Signal Transduction Positive Regulation Of Transformation Of Host Cell By Virus Animal Organ Morphogenesis Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Regulation Of Apoptotic Process Positive Regulation Of Endothelial Cell Migration Developmental Process Negative Regulation Of Apoptotic Cell Clearance Anatomical Structure Morphogenesis Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Macromolecule Metabolic Process C-X-C Chemokine Binding Alphav-beta3 Integrin-HMGB1 Complex T-helper 1 Cell Activation Positive Regulation Of Mismatch Repair Regulation Of Signal Transduction Positive Regulation Of Chemotaxis Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Epidermis Development	Sequence-specific Double-stranded DNA Binding Chromatin DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Developmental Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cell Differentiation Animal Organ Development Cell Population Proliferation Nucleus Anterior/posterior Pattern Specification Positive Regulation Of Transcription By RNA Polymerase II Cellular Developmental Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding BMP Signaling Pathway Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Odontogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Positive Regulation Of Mesenchymal Cell Apoptotic Process Positive Regulation Of Biosynthetic Process Face Morphogenesis DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regionalization Midbrain Development Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Animal Organ Morphogenesis Embryonic Nail Plate Morphogenesis Positive Regulation Of BMP Signaling Pathway Tube Morphogenesis Negative Regulation Of Biosynthetic Process
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