TLE2 and UTY

Number of citations of the paper that reports this interaction (PubMedID 9854018)
27

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vitro)

		TLE2	UTY
Description		TLE family member 2, transcriptional corepressor	ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Transcription Regulator Complex Focal Adhesion Nuclear Body	Nucleus Nucleoplasm MLL3/4 Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Oxidoreductase Activity Chromatin DNA Binding Histone Demethylase Activity Metal Ion Binding Dioxygenase Activity Histone H3K27me2/H3K27me3 Demethylase Activity
	Biological Process	Regulation Of DNA-templated Transcription Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway	Chromatin Organization Chromatin Remodeling Heart Development Regulation Of Gene Expression
Pathways		Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes	HDMs demethylate histones
Drugs
Diseases
GWAS			Autism ( 32996047)
Interacting Genes		16 interacting genes: BARHL1 EMX2 FOXA3 H3-3A HES1 HMGB1 LEF1 MSX1 MSX2 PAX9 PRDM1 RUNX1 TLE1 TLX3 UTY VENTX	4 interacting genes: PRDX2 TLE1 TLE2 USP7
Entrez ID		7089	7404
HPRD ID		03025	02451
Ensembl ID		ENSG00000065717	ENSG00000183878
Uniprot IDs		K7EMK7 Q04725	A0A087X0Y2 A0A087X248 A0A087X2I9 A0A096LPD8 A0A8C8KHL4 E1NZ93 E1U198 E1U1M3 E1U1M9 F4MH27 F4MH29 F4MH30 F4MH31 F4MH32 F4MH35 F4MH36 F4MH40 F4MH46 F4MH47 F4MH50 F4MH51 F4MH58 F4MH60 F4MH62 F4MH91 F4MH92 F5GWV3 F5H3N7 F5H8B4 O14607
PDB IDs			3ZLI 3ZPO 4UF0 5A1L 5FXV 5FXW 5FXX 5FXZ 5FY0 5FY1 5FY7 5FYM
Enriched GO Terms of Interacting Partners?		Sequence-specific Double-stranded DNA Binding Chromatin DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Developmental Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cell Differentiation Animal Organ Development Cell Population Proliferation Nucleus Anterior/posterior Pattern Specification Positive Regulation Of Transcription By RNA Polymerase II Cellular Developmental Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding BMP Signaling Pathway Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Odontogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Positive Regulation Of Mesenchymal Cell Apoptotic Process Positive Regulation Of Biosynthetic Process Face Morphogenesis DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regionalization Midbrain Development Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Animal Organ Morphogenesis Embryonic Nail Plate Morphogenesis Positive Regulation Of BMP Signaling Pathway Tube Morphogenesis Negative Regulation Of Biosynthetic Process	Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Respiratory Burst Involved In Inflammatory Response Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Communication Regulation Of Signal Transduction Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Regulation Of Signaling Thioredoxin Peroxidase Activity Transcription Regulator Complex Transcription Corepressor Activity Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Retrograde Transport, Endosome To Golgi Respiratory Burst Involved In Defense Response Regulation Of Wnt Signaling Pathway Monoubiquitinated Protein Deubiquitination Defense Response To Tumor Cell Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Production Of Molecular Mediator Involved In Inflammatory Response Beta-catenin-TCF Complex Nuclear Body DNA Alkylation Repair Transcription-coupled Nucleotide-excision Repair Regulation Of Telomere Capping Removal Of Superoxide Radicals Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Hydrogen Peroxide Metabolic Process Signal Transduction Hydrogen Peroxide Catabolic Process Negative Regulation Of Anoikis Negative Regulation Of Gluconeogenesis K48-linked Deubiquitinase Activity Respiratory Burst Antioxidant Activity Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Blood Coagulation Animal Organ Morphogenesis Regulation Of Anoikis Deubiquitinase Activity Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Coagulation Peroxidase Activity
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