HMOX2 and SETDB1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HMOX2	SETDB1
Description		heme oxygenase 2	SET domain bifurcated histone lysine methyltransferase 1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane	Nucleus Nucleoplasm Chromosome Cytoplasm
	Molecular Function	Heme Oxygenase (decyclizing) Activity Protein Binding Oxidoreductase Activity Heme Binding Metal Ion Binding	DNA Binding Chromatin Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Monomethyltransferase Activity Histone H3K9 Trimethyltransferase Activity Promoter-specific Chromatin Binding
	Biological Process	Response To Hypoxia Heme Oxidation Response To Oxidative Stress Heme Catabolic Process	Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Negative Regulation Of Gene Expression Methylation Heterochromatin Organization Transposable Element Silencing By Heterochromatin Formation
Pathways		Heme degradation Neutrophil degranulation RHOA GTPase cycle Iron uptake and transport Cytoprotection by HMOX1	PKMTs methylate histone lysines Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs		NADH Stannsoporfin
Diseases
GWAS		Erectile dysfunction ( 30583798)	Body mass index ( 26426971) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Chronic kidney disease ( 20383146) Coffee consumption ( 31046077) Cutaneous squamous cell carcinoma ( 32041948) Hip circumference adjusted for BMI ( 34021172) Melanoma ( 21983785) Neurological blood protein biomarker levels ( 31320639) Nevus count or cutaneous melanoma ( 30429480)
Interacting Genes		68 interacting genes: A2M APP AQP6 ARL13B ASGR2 ATP5F1B BCL2L13 BIK BLOC1S2 CCR2 CD79A CEBPZ CEP126 COPS6 CRB3 CSNK2A1 EBP EEF1G EIF3C ELOVL4 ERGIC3 F2RL1 FAM209A FAM210B GET1 GIT1 GPR152 GPRASP1 GPX8 HAP1 IMMT INPP5K ITFG1 JADE1 KCNJ6 KCNMA1 LAPTM5 LRIF1 MARK3 MED31 MGST3 MTNR1A NDUFS2 NKRF NR3C1 PCNT PLXNB2 PTGER4 RBBP4 RETREG3 RNASEK SAR1A SETDB1 SGPL1 SHC1 SKA2 SLC30A8 SMO SNX5 SNX7 SSMEM1 STOM SYT1 TMEM14B TMX2 VMA21 ZFP28 ZNF746	111 interacting genes: AIFM1 AKT1 ANXA7 APC APLP1 ASAH1 ATF7IP ATF7IP2 BAG6 BARD1 BHLHE40 BID BRIX1 BTBD2 BTG3 CBX8 CCDC106 CDK4 CDKN1A CFAP68 CLSTN1 CREBBP CRELD1 DAP DLEU1 DNMT3A ECSIT ERG ERH FAM118B FLYWCH1 GIPC2 GPS2 GRB7 GSTO1 H3-4 H3C1 H3C15 H4C16 HDAC1 HDAC2 HMOX2 HSPB3 JARID2 KDM1A LRIF1 LUC7L2 MAD2L1BP MAP4K5 MBD1 MDM2 MOB4 MRPL44 MZT2B NIPSNAP3A OLFML3 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PGAM5 PHF10 PIAS4 PLEKHA4 POLA2 PPA1 PPP1R8 PRKRA PSMD11 PSME1 PTPRS QTRT1 RIF1 RNF10 S100A10 SAT1 SERPINB9 SIN3A SIN3B SKIL SLC38A3 SMN1 SNIP1 SUFU SULT1E1 SUMO2 TARDBP TCERG1 THAP8 TK1 TOB1 TOLLIP TPI1 TRBV2 TRDMT1 TRIB3 TRIM16 TRIM28 TRIP6 TSC22D1 TSPAN15 TTR TXNDC9 UBE2I ULK2 USP11 VHL VIM ZFP64 ZNF24
Entrez ID		3163	9869
HPRD ID		00783	06828
Ensembl ID		ENSG00000103415	ENSG00000143379
Uniprot IDs		A0A087WT44 B3KSE0 P30519	A0A8I5KT93 Q15047 X6R732
PDB IDs		2Q32 2QPP 2RGZ 4WMH 5UC8 5UC9 5UCA	3DLM 4X3S 5KCH 5KCO 5KE2 5KE3 5KH6 5QT1 5QT2 6AU2 6AU3 6BHD 6BHE 6BHG 6BHH 6BHI 6BPI 7C9N 7CAJ 7CD9 7CJT 8G5E 8IYA 8UWP 9CUW 9CUX
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding	Transcription Corepressor Activity Nucleus Nucleoplasm Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic SUMO Transferase Activity Regulation Of RNA Metabolic Process Chromatin Remodeling Epigenetic Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress Chromatin Organization Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Transcription Coregulator Activity Constitutive Heterochromatin Formation Cytoplasm MRF Binding Chromatin Binding Transcription Regulator Complex DNA Methylation-dependent Constitutive Heterochromatin Formation Ubiquitin Protein Ligase Binding Sin3-type Complex Regulation Of Mitotic Cell Cycle Phase Transition Heterochromatin Protein Sumoylation Nuclear Matrix Nuclear Body RNA Binding Regulation Of Intrinsic Apoptotic Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Proteolysis Krueppel-associated Box Domain Binding Enzyme Binding
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