ANXA2 and PLA1A

Number of citations of the paper that reports this interaction (PubMedID 1531641)
0

Data Source:
HPRD (in vitro, in vivo)

		ANXA2	PLA1A
Description		annexin A2	phospholipase A1 member A
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Basement Membrane Extracellular Space Nucleus Cytoplasm Lysosomal Membrane Endosome Early Endosome Lipid Droplet Cytosol Plasma Membrane Adherens Junction Cell Surface Vesicle Membrane Membrane Basolateral Plasma Membrane Nuclear Matrix Midbody Extracellular Matrix Late Endosome Membrane Vesicle Azurophil Granule Lumen Myelin Sheath Adaxonal Region Sarcolemma Melanosome Schmidt-Lanterman Incisure Membrane Raft Extracellular Exosome RNA Polymerase II Transcription Regulator Complex Plasma Membrane Protein Complex AnxA2-p11 Complex PCSK9-AnxA2 Complex	Acrosomal Membrane Extracellular Region Extracellular Space
	Molecular Function	Phosphatidylserine Binding Protease Binding RNA Binding Phospholipase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Phospholipase A2 Inhibitor Activity Identical Protein Binding S100 Protein Binding Calcium-dependent Protein Binding Cadherin Binding Involved In Cell-cell Adhesion	Phospholipase A1 Activity Lipase Activity Hydrolase Activity Carboxylic Ester Hydrolase Activity
	Biological Process	Angiogenesis Membrane Raft Assembly Positive Regulation Of Receptor Recycling Negative Regulation Of Receptor Internalization Vesicle Budding From Membrane Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Plasminogen Activation Response To Activity Collagen Fibril Organization Lung Development Positive Regulation Of Vesicle Fusion Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Osteoclast Development Fibrinolysis MRNA Transcription By RNA Polymerase II Positive Regulation Of Vacuole Organization Positive Regulation Of Exocytosis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Negative Regulation Of Transport Positive Regulation Of Multicellular Organismal Process Cell-cell Adhesion Epithelial Cell Apoptotic Process Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Positive Regulation Of Plasma Membrane Repair	Lipid Metabolic Process Phosphatidylserine Metabolic Process Lipid Catabolic Process Phosphatidylserine Acyl-chain Remodeling
Pathways		Smooth Muscle Contraction Neutrophil degranulation Dissolution of Fibrin Clot Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Developmental Lineage of Pancreatic Ductal Cells	Acyl chain remodelling of PS
Drugs		Tenecteplase Fluocinolone acetonide Lanoteplase Artenimol
Diseases
GWAS		Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Blood protein levels ( 30072576) Night sleep phenotypes ( 27126917) Type 2 diabetes ( 25102180)
Interacting Genes		52 interacting genes: ACTA1 APOH APP CCDC32 CD99 CDC42 CEACAM1 CTSB CTSS DYSF EIF4ENIF1 FNDC3B FOXP1 GRB2 HMGA1 LGALS13 LINC00941 LINC01554 LYPLA1 MAP3K4 MYOC NOD2 OGDH PHB1 PLA1A PLA2G4A PLAT PLG POT1 PRKCA PRKCB PTEN RPS2 S100A10 S100A4 S100A6 SLC26A4-AS1 SMAD6 SMN1 SNCA SNX17 SOS1 SRC STAT6 TENT2 TERF1 TERT TNC TRPV5 WEE2-AS1 YWHAQ ZBTB4	3 interacting genes: ANXA2 APP CD47
Entrez ID		302	51365
HPRD ID		01061	07078
Ensembl ID		ENSG00000182718	ENSG00000144837
Uniprot IDs		A0A024R5Z7 H0YL33 P07355	G5E9W0 Q53H76
PDB IDs		1W7B 1XJL 2HYU 2HYV 2HYW 4DRW 4FTG 4HRH 5LPU 5LPX 5LQ0 5LQ2 5N7D 5N7F 5N7G 6TWQ 6TWU 6TWX 6TWY 7DTO 7EQ7 7NMI 7P70 7P71 7P72 7P73 7P74 7PC3 7PC4 7PC5 7PC7 7PC8 7PC9 7PCB 7QQL 7QQM 7QQN 7ZVN 7ZVX 8AEL
Enriched GO Terms of Interacting Partners?		Regulation Of Vesicle-mediated Transport Extracellular Exosome Regulation Of Cell Population Proliferation Enzyme Binding Regulation Of Locomotion Negative Regulation Of Wound Healing Regulation Of Transport Nuclear Telomere Cap Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Migration Positive Regulation Of Metabolic Process Negative Regulation Of Fibrinolysis Leukocyte Activation Regulation Of Cell Motility Positive Regulation Of Immune System Process Histone H3T6 Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Regulation Of Cell Junction Assembly Regulation Of Fibrinolysis Negative Regulation Of Coagulation Regulation Of Cell Activation Positive Regulation Of Organelle Organization Regulation Of Immune Response Cell Activation Regulation Of Cell Adhesion Regulation Of MAPK Cascade Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Immune Response Phosphatidylcholine Lysophospholipase Activity Extracellular Matrix Identical Protein Binding Macrophage Activation Positive Regulation Of Cell Migration Regulation Of Endocytosis Negative Regulation Of Cell-substrate Adhesion Telomere Maintenance Via Telomerase Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Biosynthetic Process Regulation Of Immune System Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Myeloid Leukocyte Activation Positive Regulation Of Signal Transduction Regulation Of Cell-substrate Adhesion Regulation Of Focal Adhesion Assembly Trans-synaptic Signaling By BDNF Protein Kinase C Signaling	Positive Regulation Of Endocytosis Regulation Of Endocytosis Regulation Of Receptor Internalization Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Endocytosis Myeloid Cell Development Cell Surface Regulation Of Vesicle-mediated Transport Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Serine-type Endopeptidase Inhibitor Activity Response To Interleukin-1 Cell Death Apoptotic Process Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Transport Cell Adhesion Programmed Cell Death Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Mononuclear Cell Migration Regulation Of Response To Calcium Ion Regulation Of Type II Interferon Production Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Positive Regulation Of Cellular Component Organization AnxA2-p11 Complex PCSK9-AnxA2 Complex Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Hemopoiesis Acetylcholine Receptor Activator Activity Positive Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor Production Regulation Of Interleukin-6 Production Positive Regulation Of Supramolecular Fiber Organization Lipoprotein Particle Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Protein Import Cellular Response To Interleukin-12 Positive Regulation Of Proteolysis Membrane Raft Negative Regulation Of Receptor Catabolic Process Positive Regulation Of Intracellular Cholesterol Transport PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Leukocyte Migration Endosome To Plasma Membrane Transport Vesicle
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