H2AZ1 and FH

Number of citations of the paper that reports this interaction (PubMedID 26237645)
30

Data Source:
BioGRID (pull down)

		H2AZ1	FH
Description		H2A.Z variant histone 1	fumarate hydratase
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GO Annotations	Cellular Component	Nucleosome Euchromatin Heterochromatin Barr Body Nucleus Chromosome Extracellular Exosome	Nucleus Chromosome Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Site Of Double-strand Break Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding Protein Heterodimerization Activity	Catalytic Activity Fumarate Hydratase Activity Protein Binding Lyase Activity Histone Binding
	Biological Process	Chromatin Organization Heterochromatin Formation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus	Urea Cycle Regulation Of Arginine Metabolic Process Tricarboxylic Acid Cycle Fumarate Metabolic Process Malate Metabolic Process DNA Repair Arginine Metabolic Process DNA Damage Response Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Amyloid fiber formation	Citric acid cycle (TCA cycle) Mitochondrial protein degradation
Drugs
Diseases			Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogenase (SDH) deficiency; Alpha-ketoglutarate dehydrogenase (AKGDH) deficiency Multiple cutaneous and uterine leiomyomata Renal cell carcinoma
GWAS			Daytime sleep phenotypes ( 27126917) Major depressive disorder ( 27479909) Metabolite levels ( 23823483)
Interacting Genes		8 interacting genes: FH INCENP MAGEC1 NCAPH PIAS1 RNF168 RNF169 USP16	18 interacting genes: CCDC102B CCDC57 CCNDBP1 CSTPP1 DGCR6 EXOSC5 GRB2 H2AZ1 KLHL6 LMNB2 MDH2 OGT PIM1 POLR1C PRKDC SAT1 TNPO2 TTC19
Entrez ID		3015	2271
HPRD ID		00823	00652
Ensembl ID		ENSG00000164032	ENSG00000091483
Uniprot IDs		P0C0S5	A0A0S2Z4C3 P07954
PDB IDs		1F66 3WA9 4CAY 4NFT 5B31 5B32 5B33 5CHL 5FUG 5Z30 6JOU 6KO2 7YRD 7YRG 8JHF 8T9F 8THU 9C62	3E04 5D6B 5UPP 6EBT 6V8F 6VBE 7LUB
Enriched GO Terms of Interacting Partners?		DNA Damage Response Site Of Double-strand Break Histone Binding DNA Repair K63-linked Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Chromosome Separation Positive Regulation Of Chromosome Segregation Nucleosome Binding Chromosome Regulation Of DNA Repair Double-strand Break Repair DNA Recombination DNA Metabolic Process Cellular Response To Stress Fumarate Metabolic Process Fumarate Hydratase Activity Nucleus Meiotic Spindle Midzone Post-translational Protein Modification Positive Regulation Of Ribosome Biogenesis Double-strand Break Repair Via Nonhomologous End Joining Histone H2AK15 Ubiquitin Ligase Activity Regulation Of Chromosome Separation Nuclear Division Regulation Of Cell Cycle Meiotic Spindle Midzone Assembly Cell Division Female Meiosis Chromosome Separation Ubiquitin Binding Regulation Of DNA Metabolic Process Histone Ubiquitin Ligase Activity Regulation Of Cellular Response To Stress Positive Regulation Of DNA Repair Regulation Of Chromosome Segregation Chromosome Segregation Mitotic Cell Cycle Recombinational Repair Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Translational Elongation Meiotic Chromosome Separation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Double-strand Break Repair Regulation Of Arginine Metabolic Process Female Meiosis Chromosome Segregation Nucleoplasm Chromosome Passenger Complex Regulation Of Ribosome Biogenesis Mitotic Nuclear Division Histone H2A Deubiquitinase Activity Meiotic Chromosome Condensation	Non-canonical Inflammasome Complex Assembly
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