FH

Description		fumarate hydratase
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GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Site Of Double-strand Break Extracellular Exosome
	Molecular Function	Catalytic Activity Fumarate Hydratase Activity Protein Binding Lyase Activity Histone Binding
	Biological Process	Urea Cycle Regulation Of Arginine Metabolic Process Tricarboxylic Acid Cycle Fumarate Metabolic Process Malate Metabolic Process DNA Repair Arginine Metabolic Process DNA Damage Response Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Citric acid cycle (TCA cycle) Mitochondrial protein degradation
Drugs
Diseases		Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogenase (SDH) deficiency; Alpha-ketoglutarate dehydrogenase (AKGDH) deficiency Multiple cutaneous and uterine leiomyomata Renal cell carcinoma
GWAS		Daytime sleep phenotypes ( 27126917) Major depressive disorder ( 27479909) Metabolite levels ( 23823483)
Interacting Genes		18 interacting genes: CCDC102B CCDC57 CCNDBP1 CSTPP1 DGCR6 EXOSC5 GRB2 H2AZ1 KLHL6 LMNB2 MDH2 OGT PIM1 POLR1C PRKDC SAT1 TNPO2 TTC19
Entrez ID		2271
HPRD ID		00652
Ensembl ID		ENSG00000091483
Uniprot IDs		A0A0S2Z4C3 P07954
PDB IDs		3E04 5D6B 5UPP 6EBT 6V8F 6VBE 7LUB
Enriched GO Terms of Interacting Partners?		Non-canonical Inflammasome Complex Assembly
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