H1-4 and CBX3

Number of citations of the paper that reports this interaction (PubMedID 22514736)
48

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vitro)

		H1-4	CBX3
Description		H1.4 linker histone, cluster member	chromobox 3
Image
GO Annotations	Cellular Component	Chromatin Nucleosome Euchromatin Heterochromatin Nucleus Chromosome	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Euchromatin Heterochromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Pericentric Heterochromatin Spindle Senescence-associated Heterochromatin Focus Chromatin Lock Complex RNA Polymerase II Transcription Regulator Complex Site Of DNA Damage
	Molecular Function	DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding Histone Deacetylase Binding	Transcription Coregulator Binding Chromatin Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Methyltransferase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Regulation Of Transcription By RNA Polymerase II Chromosome Condensation Negative Regulation Of DNA Recombination	Chromatin Organization Chromatin Remodeling DNA Damage Response Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Rhythmic Process Cellular Response To Dexamethasone Stimulus
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Promoter Escape Transcriptional Regulation by E2F6
Drugs		Copper
Diseases
GWAS			Metabolite levels ( 23823483) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		10 interacting genes: CBX1 CBX3 CBX5 FOXP1 IL7R IRAK4 OGT PDE4B PRKCA RBFOX2	42 interacting genes: ADAMTSL4 ADNP2 ARL5A ATXN7L2 AURKA AURKB BARD1 CACNB4 CBX1 CBX5 CDC42 DNMT3B DSN1 GDF15 H1-4 H3-4 H3C1 H4C1 HECW2 HIPK2 HTR2C KLF11 L3MBTL1 LAP3 LBR LIG1 MGA MIS12 MKI67 MRPL12 NSD3 PIM1 RAD54L2 SP100 STK16 TAF4 TRIM24 TRIM28 VHL ZNF10 ZNF280D ZNF496
Entrez ID		3008	11335
HPRD ID		07513	05130
Ensembl ID		ENSG00000168298	ENSG00000122565
Uniprot IDs		A3R0T8 P10412	A4D177 B8ZZ43 Q13185
PDB IDs		3TZD 5JJZ 6H8P 7K5Y 7K63 7PET 7PEU 7PEX 7PEZ 7PF0 7PF2 7PF3 7PF5 7PF6 7PFA 7PFC 7PFD 7PFE 7PFT 7PFU 7PFV 7PFW 7PFX 8H1T 8VG2 9DDE	2L11 3DM1 3KUP 3TZD 5T1I 6HW2 8JZW
Enriched GO Terms of Interacting Partners?		Pericentric Heterochromatin Site Of DNA Damage Heterochromatin Negative Regulation Of Gene Expression Positive Regulation Of Smooth Muscle Cell Proliferation Chromocenter Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Stress Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Chromatin Organization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Heterochromatin Formation Histone Methyltransferase Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Hemopoiesis Negative Regulation Of Gene Expression, Epigenetic Chromosome, Centromeric Region Chromosome, Telomeric Region Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Immune System Process Negative Regulation Of Lymphocyte Apoptotic Process Nucleoplasm Negative Regulation Of Metabolic Process Response To Ketone Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Regulation Of Muscle System Process Chromatin Remodeling Epigenetic Regulation Of Gene Expression Negative Regulation Of Leukocyte Apoptotic Process Regulation Of Metabolic Process Regulation Of Lymphocyte Apoptotic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Neutrophil Migration Response To Lipid Regulation Of Cardiac Muscle Hypertrophy DNA Damage Response Regulation Of RNA Metabolic Process Leukocyte Homeostasis Regulation Of Primary Metabolic Process Regulation Of Immune System Process Interleukin-7 Receptor Activity	Chromatin Remodeling Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of RNA Metabolic Process DNA Binding Heterochromatin Regulation Of Mitotic Cell Cycle Chromo Shadow Domain Binding Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Chromocenter Chromosome Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Nuclear Division Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Heterochromatin Formation Regulation Of Nuclear Division Nuclear Body Regulation Of Cell Cycle Spindle Midzone MIS12/MIND Type Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Kinetochore Chromosome, Centromeric Region Regulation Of Cell Cycle Process Structural Constituent Of Chromatin Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region Protein-containing Complex Chromosome Passenger Complex Attachment Of Spindle Microtubules To Kinetochore Protein-DNA Complex Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleosome Assembly Negative Regulation Of Protein Export From Nucleus Regulation Of Mitotic Cell Cycle Phase Transition Protein Heterodimerization Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process
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