SERTAD3 and SPG11

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SERTAD3	SPG11
Description		SERTA domain containing 3	SPG11 vesicle trafficking associated, spatacsin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleolus Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Cytosol Plasma Membrane Axon Dendrite Cytoplasmic Vesicle Cell Projection Synapse
	Molecular Function	Protein Binding	Protein Binding Protein Kinase Binding
	Biological Process	Regulation Of DNA-templated Transcription Negative Regulation Of Cell Growth Positive Regulation Of DNA-templated Transcription	Protein Import Into Nucleus Intracellular Protein Transport Lysosome Organization Chemical Synaptic Transmission Axonogenesis Neuromuscular Junction Development Memory Axo-dendritic Transport Intracellular Protein Localization Corticospinal Tract Morphogenesis Protein Catabolic Process Cholesterol Efflux Vesicle Transport Along Microtubule Synaptic Vesicle Transport Axon Extension Skeletal Muscle Fiber Development Neuron Apoptotic Process Localization Within Membrane Motor Behavior Phagosome-lysosome Fusion Involved In Apoptotic Cell Clearance Walking Behavior Motor Neuron Apoptotic Process Autophagosome Organization Regulation Of Store-operated Calcium Entry
Pathways
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Mean reticulocyte volume ( 32888494) Otitis media ( 27632927) Otitis media (chronic) ( 27632927) Otitis media (recurrent) ( 27632927)	Anti-Toxoplasma gondii IgG seropositivity ( 30610941) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		44 interacting genes: ANKRD11 BEX2 BFSP2 C1orf216 CCNC CENPP CREBBP CTNNAL1 DPPA3 FAAP20 FBXO44 FCHSD2 GTPBP3 HGS IL16 IMP3 KANK2 KLHL42 KPNA2 MBD3 MED25 MSGN1 NDN NPPB P4HA3 PICK1 PKN1 PRKAA2 RPA2 RTP5 SMARCD1 SNRPB SPG11 SUOX TASOR2 TBCE TLE5 TNPO2 TPRX1 TRAPPC6A TXN UBL5 USHBP1 ZGPAT	2 interacting genes: PAK6 SERTAD3
Entrez ID		29946	80208
HPRD ID		15327	07963
Ensembl ID		ENSG00000167565	ENSG00000104133
Uniprot IDs		Q9UJW9	A0A804HID9 Q96JI7
PDB IDs
Enriched GO Terms of Interacting Partners?
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