GPR132 and KLC1

		GPR132	KLC1
Description		G protein-coupled receptor 132	kinesin light chain 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytoplasm Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Growth Cone Cytoplasmic Vesicle Cell Projection
	Molecular Function	G Protein-coupled Receptor Activity	Cytoskeletal Motor Activity Protein Binding Kinesin Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle	Microtubule-based Movement Cell Adhesion Stress Granule Disassembly
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (q) signalling events	MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants Kinesins
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Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 25673413 28892062) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061) Smoking behaviour (cigarette pack-years) ( 30679032) Urate levels ( 31578528)
Interacting Genes		1 interacting genes: KLC1	33 interacting genes: ADRB2 AP1AR APP ATCAY BNIP2 CDC42BPB CLSTN1 ERBB2 F2RL1 GPR132 HSPB1 JAG2 KIF2A KIF5C KLC2 KRT31 LRSAM1 MAPK6 MAPK8IP1 MAPK8IP2 MAPK8IP3 NIN ODAD1 ODF1 PCM1 PLEKHM2 POLR1E PTGER4 SNCA SPAG9 TACC3 TSC1 YWHAB
Entrez ID		29933	3831
HPRD ID		06936	02489
Ensembl ID		ENSG00000183484	ENSG00000126214
Uniprot IDs		Q9UNW8	F8W6L3 G3V2E7 G3V3H3 G3V5R9 G5E9S8 Q07866 Q7RTQ2
PDB IDs		8HQE 8HQM 8HQN 8HVI	3NF1 5OJ8 7AI4 7AIE
Enriched GO Terms of Interacting Partners?		Stress Granule Disassembly Kinesin Complex Kinesin Binding Cytoskeletal Motor Activity Organelle Disassembly Protein-containing Complex Disassembly Growth Cone Microtubule	Kinesin Binding MAP-kinase Scaffold Activity JUN Kinase Binding Protein Localization To Synapse Positive Regulation Of MAPK Cascade Microtubule-based Process Perinuclear Region Of Cytoplasm Microtubule-based Movement Protein Localization To Cell Junction Anterograde Axonal Protein Transport Protein Transport Along Microtubule Organelle Localization Regulation Of MAPK Cascade MAPK Cascade Regulation Of JNK Cascade Cytoskeleton Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Projection Axonal Growth Cone Axo-dendritic Transport Transport Along Microtubule Ciliary Basal Body Lysosome Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Protein-containing Complex Leukocyte Activation Anterograde Axonal Transport Protein Kinase Inhibitor Activity Kinesin Complex Axon Modulation Of Excitatory Postsynaptic Potential Receptor Localization To Synapse Positive Regulation Of Signal Transduction Centriolar Subdistal Appendage Mitotic Spindle Growth Cone Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Projection Organization Intracellular Signaling Cassette Lysosome Localization Microtubule Anchoring At Centrosome Regulation Of G Protein-coupled Receptor Signaling Pathway Cytoplasm Cell Activation JNK Cascade
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