KLC1 and CDC42BPB

		KLC1	CDC42BPB
Description		kinesin light chain 1	CDC42 binding protein kinase beta
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Growth Cone Cytoplasmic Vesicle Cell Projection	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Membrane Lamellipodium Cell Leading Edge Actomyosin Cell Projection Extracellular Exosome Anchoring Junction
	Molecular Function	Cytoskeletal Motor Activity Protein Binding Kinesin Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Protein-containing Complex Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Microtubule-based Movement Cell Adhesion Stress Granule Disassembly	Protein Phosphorylation Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell Migration Actin Cytoskeleton Organization Actomyosin Structure Organization
Pathways		MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants Kinesins	CDC42 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 25673413 28892062) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061) Smoking behaviour (cigarette pack-years) ( 30679032) Urate levels ( 31578528)	A body shape index ( 34021172) Body mass index ( 26426971) Large B-cell lymphoma ( 21471979) Mean platelet volume ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		33 interacting genes: ADRB2 AP1AR APP ATCAY BNIP2 CDC42BPB CLSTN1 ERBB2 F2RL1 GPR132 HSPB1 JAG2 KIF2A KIF5C KLC2 KRT31 LRSAM1 MAPK6 MAPK8IP1 MAPK8IP2 MAPK8IP3 NIN ODAD1 ODF1 PCM1 PLEKHM2 POLR1E PTGER4 SNCA SPAG9 TACC3 TSC1 YWHAB	10 interacting genes: AMN CDC42 KLC1 MAP2K5 MARK3 PPM1A PPP2CA PYGM RIPK1 WDR4
Entrez ID		3831	9578
HPRD ID		02489	08516
Ensembl ID		ENSG00000126214	ENSG00000198752
Uniprot IDs		F8W6L3 G3V2E7 G3V3H3 G3V5R9 G5E9S8 Q07866 Q7RTQ2	H0YLY0 Q86XZ8 Q9Y5S2
PDB IDs		3NF1 5OJ8 7AI4 7AIE	3QFV 3TKU 4UAK 4UAL 5OTE 5OTF
Enriched GO Terms of Interacting Partners?		Kinesin Binding MAP-kinase Scaffold Activity JUN Kinase Binding Protein Localization To Synapse Positive Regulation Of MAPK Cascade Microtubule-based Process Perinuclear Region Of Cytoplasm Microtubule-based Movement Protein Localization To Cell Junction Anterograde Axonal Protein Transport Protein Transport Along Microtubule Organelle Localization Regulation Of MAPK Cascade MAPK Cascade Regulation Of JNK Cascade Cytoskeleton Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Projection Axonal Growth Cone Axo-dendritic Transport Transport Along Microtubule Ciliary Basal Body Lysosome Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Protein-containing Complex Leukocyte Activation Anterograde Axonal Transport Protein Kinase Inhibitor Activity Kinesin Complex Axon Modulation Of Excitatory Postsynaptic Potential Receptor Localization To Synapse Positive Regulation Of Signal Transduction Centriolar Subdistal Appendage Mitotic Spindle Growth Cone Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Projection Organization Intracellular Signaling Cassette Lysosome Localization Microtubule Anchoring At Centrosome Regulation Of G Protein-coupled Receptor Signaling Pathway Cytoplasm Cell Activation JNK Cascade	Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Hippo Signaling Cellular Response To Fluid Shear Stress Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intracellular Signal Transduction Regulation Of Hippo Signaling Tau Protein Binding Response To Fluid Shear Stress Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apical Part Of Cell GBD Domain Binding Storage Vacuole Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Serine Kinase Activity Cellular Response To Growth Factor Stimulus Protein Dephosphorylation Response To Growth Factor Protein Serine/threonine Phosphatase Activity Regulation Of Canonical NF-kappaB Signal Transduction RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Regulation Of Interleukin-8 Production ERK5 Cascade Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process TRNA Methyltransferase Activator Activity TRNA (m7G46) Methyltransferase Complex Protein Serine/threonine Kinase Activity Nucleotide Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Glycogen Phosphorylase Activity Positive Regulation Of Interleukin-6-mediated Signaling Pathway Death Domain Binding TRNA (guanine-N7)-methylation Apolipoprotein A-I Receptor Binding Intracellular Signal Transduction Neuropilin Signaling Pathway Regulation Of Cell Cycle Cytosol N-terminal Protein Myristoylation Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Mitotic Cell Cycle Protein Kinase Activity
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