TMOD3 and TNFSF11

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		TMOD3	TNFSF11
Description		tropomodulin 3	TNF superfamily member 11
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Striated Muscle Thin Filament Adherens Junction Myofibril	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Membrane
	Molecular Function	Actin Binding Protein Binding Tropomyosin Binding Cadherin Binding Involved In Cell-cell Adhesion	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding Identical Protein Binding Receptor Ligand Activity
	Biological Process	Muscle Contraction Actin Filament Organization Actin Cytoskeleton Organization Myofibril Assembly Mitotic Cell Cycle Phase Transition Erythrocyte Development Pointed-end Actin Filament Capping Cell-cell Adhesion Positive Regulation Of Mitotic Cell Cycle Phase Transition	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoclast Proliferation Monocyte Chemotaxis Immune Response Cell Communication Cell Surface Receptor Signaling Pathway JNK Cascade Animal Organ Morphogenesis Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Signaling Cell Differentiation Osteoclast Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Homotypic Cell-cell Adhesion Osteoclast Development Paracrine Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Tooth Eruption Bone Resorption Regulation Of Osteoclast Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of T Cell Activation Positive Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Calcium Ion Homeostasis Bone Development Mammary Gland Alveolus Development Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Osteoclast Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Striated Muscle Contraction RHOBTB2 GTPase cycle RND3 GTPase cycle	TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Lenalidomide AMGN-0007 Denosumab Thiocolchicoside
Diseases			Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS			Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic rhinitis ( 30013184) Arthritis (juvenile idiopathic) ( 33106285) Asthma (childhood onset) ( 30929738) Bone mineral density ( 23437003 24249740) Bone mineral density (paediatric, total body less head) ( 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) C-reactive protein levels ( 24763700) Cortical thickness ( 22792071) Crohn's disease ( 21102463) Heel bone mineral density ( 30598549) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Serum alkaline phosphatase levels ( 33547301 29403010) Vitiligo ( 27723757)
Interacting Genes		6 interacting genes: CDC42 CSNK2A1 DUSP23 FURIN MAP1LC3B TNFSF11	32 interacting genes: ADAM17 ADAM19 AKT1 BBS10 CEP126 DDAH2 EEF1A1 EZH2 LMO4 MAPK1 MAPK3 MAPK8 MBTPS1 MED24 MMP1 MMP3 MMP7 NFKB1 NFKBIA OLFM4 PHAX PLK1 PRXL2B SBF1 SNRNP35 TMOD3 TNFRSF11A TNFRSF11B TRAF6 TRMT2A UPK2 ZC3HC1
Entrez ID		29766	8600
HPRD ID		10389	04031
Ensembl ID		ENSG00000138594	ENSG00000120659
Uniprot IDs		Q9NYL9	O14788 Q54A98 Q5T9Y4
PDB IDs			3URF 5BNQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Growth Mononuclear Cell Migration Apolipoprotein A-I Receptor Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Neuropilin Signaling Pathway GBD Domain Binding Storage Vacuole Myeloid Leukocyte Differentiation Negative Regulation Of Proteolysis Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Macroautophagy Negative Regulation Of Protein Catabolic Process Organelle Assembly Viral Translation Negative Regulation Of Nerve Growth Factor Production Viral Life Cycle Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Dibasic Protein Processing Organelle Membrane Zymogen Inhibition Nerve Growth Factor Production Regulation Of Lipid Transport Negative Regulation Of Receptor Catabolic Process Negative Regulation Of Neurotrophin Production Tooth Eruption Positive Regulation Of Osteoclast Development Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Aggrephagy Cytokine Precursor Processing Nerve Growth Factor Binding Osteoclast Proliferation Positive Regulation Of Pinocytosis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cell Surface Receptor Signaling Pathway Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of Protein Catabolic Process Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Fever Generation Osteoclast Development Paracrine Signaling Tumor Necrosis Factor Receptor Superfamily Binding Leukocyte Migration	Lipopolysaccharide-mediated Signaling Pathway Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Response To Tumor Necrosis Factor Response To Lipid Membrane Protein Proteolysis Endopeptidase Activity Metalloendopeptidase Activity Cellular Response To Tumor Necrosis Factor Hematopoietic Or Lymphoid Organ Development Positive Regulation Of Catalytic Activity Response To UV-A Response To DsRNA Response To Epidermal Growth Factor MAP Kinase Activity Metallopeptidase Activity Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amino Acid Starvation Regulation Of Lipid Transport Epidermal Growth Factor Receptor Signaling Pathway Response To Amino Acid Starvation Cytokine-mediated Signaling Pathway Peptidyl-threonine Phosphorylation Positive Regulation Of Cholesterol Biosynthetic Process Membrane Protein Ectodomain Proteolysis I-kappaB/NF-kappaB Complex Interleukin-34-mediated Signaling Pathway Stress-activated MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Stress Stress-activated Protein Kinase Signaling Cascade Regulation Of Steroid Biosynthetic Process Positive Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway Positive Regulation Of Defense Response Protein Metabolic Process Regulation Of Golgi Inheritance Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Cholesterol Metabolic Process Cellular Response To Starvation Regulation Of Cholesterol Biosynthetic Process Non-canonical NF-kappaB Signal Transduction Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Response To Mechanical Stimulus Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Steroid Biosynthetic Process Regulation Of Steroid Metabolic Process
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