TNFSF11 and PRXL2B

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		TNFSF11	PRXL2B
Description		TNF superfamily member 11	peroxiredoxin like 2B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Membrane	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Myelin Sheath Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding Identical Protein Binding Receptor Ligand Activity	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Prostaglandin F Synthase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoclast Proliferation Monocyte Chemotaxis Immune Response Cell Communication Cell Surface Receptor Signaling Pathway JNK Cascade Animal Organ Morphogenesis Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Signaling Cell Differentiation Osteoclast Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Homotypic Cell-cell Adhesion Osteoclast Development Paracrine Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Tooth Eruption Bone Resorption Regulation Of Osteoclast Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of T Cell Activation Positive Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Calcium Ion Homeostasis Bone Development Mammary Gland Alveolus Development Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Osteoclast Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process
Pathways		TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Transcriptional and post-translational regulation of MITF-M expression and activity	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs		Lenalidomide AMGN-0007 Denosumab Thiocolchicoside
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic rhinitis ( 30013184) Arthritis (juvenile idiopathic) ( 33106285) Asthma (childhood onset) ( 30929738) Bone mineral density ( 23437003 24249740) Bone mineral density (paediatric, total body less head) ( 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) C-reactive protein levels ( 24763700) Cortical thickness ( 22792071) Crohn's disease ( 21102463) Heel bone mineral density ( 30598549) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Serum alkaline phosphatase levels ( 33547301 29403010) Vitiligo ( 27723757)
Interacting Genes		32 interacting genes: ADAM17 ADAM19 AKT1 BBS10 CEP126 DDAH2 EEF1A1 EZH2 LMO4 MAPK1 MAPK3 MAPK8 MBTPS1 MED24 MMP1 MMP3 MMP7 NFKB1 NFKBIA OLFM4 PHAX PLK1 PRXL2B SBF1 SNRNP35 TMOD3 TNFRSF11A TNFRSF11B TRAF6 TRMT2A UPK2 ZC3HC1	4 interacting genes: COPS3 PDPK1 TCP11L1 TNFSF11
Entrez ID		8600	127281
HPRD ID		04031	14513
Ensembl ID		ENSG00000120659	ENSG00000157870
Uniprot IDs		O14788 Q54A98 Q5T9Y4	A0A0A0MRV4 A0A0A0MT35 A0A2P0CTB1 A0A2P0CU24 J3KPF5 Q8TBF2
PDB IDs		3URF 5BNQ
Enriched GO Terms of Interacting Partners?		Lipopolysaccharide-mediated Signaling Pathway Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Response To Tumor Necrosis Factor Response To Lipid Membrane Protein Proteolysis Endopeptidase Activity Metalloendopeptidase Activity Cellular Response To Tumor Necrosis Factor Hematopoietic Or Lymphoid Organ Development Positive Regulation Of Catalytic Activity Response To UV-A Response To DsRNA Response To Epidermal Growth Factor MAP Kinase Activity Metallopeptidase Activity Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amino Acid Starvation Regulation Of Lipid Transport Epidermal Growth Factor Receptor Signaling Pathway Response To Amino Acid Starvation Cytokine-mediated Signaling Pathway Peptidyl-threonine Phosphorylation Positive Regulation Of Cholesterol Biosynthetic Process Membrane Protein Ectodomain Proteolysis I-kappaB/NF-kappaB Complex Interleukin-34-mediated Signaling Pathway Stress-activated MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Stress Stress-activated Protein Kinase Signaling Cascade Regulation Of Steroid Biosynthetic Process Positive Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway Positive Regulation Of Defense Response Protein Metabolic Process Regulation Of Golgi Inheritance Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Cholesterol Metabolic Process Cellular Response To Starvation Regulation Of Cholesterol Biosynthetic Process Non-canonical NF-kappaB Signal Transduction Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Response To Mechanical Stimulus Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Steroid Biosynthetic Process Regulation Of Steroid Metabolic Process	Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Regulation Of Leukocyte Cell-cell Adhesion 3-phosphoinositide-dependent Protein Kinase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Calcium-mediated Signaling Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Phospholipase Activator Activity Regulation Of T Cell Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Type B Pancreatic Cell Development Positive Regulation Of Cell Activation Regulation Of Canonical NF-kappaB Signal Transduction Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Protein Deneddylation Tooth Eruption Positive Regulation Of Osteoclast Development Positive Regulation Of Bone Resorption Positive Regulation Of Fever Generation Osteoclast Development Positive Regulation Of Heat Generation Regulation Of Osteoclast Development Osteoclast Proliferation Paracrine Signaling Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Regulation Of Corticotropin-releasing Hormone Secretion Tumor Necrosis Factor Receptor Superfamily Binding Positive Regulation Of Corticotropin-releasing Hormone Secretion Regulation Of Fever Generation Vascular Endothelial Cell Response To Fluid Shear Stress Signal Transduction Positive Regulation Of Icosanoid Secretion Mammary Gland Alveolus Development Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Cell Adhesion Negative Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Phospholipase Binding Cellular Response To Laminar Fluid Shear Stress Response To Laminar Fluid Shear Stress Positive Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Protein Neddylation Protein Neddylation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Fatty Acid Transport Regulation Of Lymphocyte Activation Monocyte Chemotaxis
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