PACSIN3 and TNFSF4

		PACSIN3	TNFSF4
Description		protein kinase C and casein kinase substrate in neurons 3	TNF superfamily member 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Membrane Extracellular Exosome	Extracellular Space Plasma Membrane Cell Surface Membrane
	Molecular Function	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Lipid Binding Calcium Channel Inhibitor Activity Identical Protein Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding
	Biological Process	Endocytosis Cytoskeleton Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Calcium Ion Transport Plasma Membrane Tubulation	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cytokine Production Defense Response To Nematode Acute Inflammatory Response Positive Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Cytokine Production Regulation Of Adaptive Immune Response Positive Regulation Of Type 2 Immune Response Positive Regulation Of Immunoglobulin Mediated Immune Response Inflammatory Response Immune Response Cell Communication Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Virus Signaling Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Chemokine Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Memory T Cell Activation T-helper 2 Cell Activation Response To Nitrogen Dioxide Positive Regulation Of T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Memory T Cell Differentiation Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of B Cell Activation Cellular Response To Lipopolysaccharide Cellular Response To Prostaglandin E Stimulus Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes
Pathways		Clathrin-mediated endocytosis	TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Waist-to-hip ratio adjusted for body mass index ( 26785701)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Alopecia areata ( 25337690) Asthma ( 32296059 31361310 27182965 30929738 34103634) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Celiac disease ( 20190752 24999842) Crohn's disease ( 21102463) Diabetic retinopathy ( 21441570) IgA levels ( 28628107) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 28714469 19838193 27399966 26663301 26502338 23273568 32771030 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989) Vein graft stenosis in coronary artery bypass grafting ( 25881214)
Interacting Genes		25 interacting genes: ADAM12 ADAM15 ASAP1 ASAP2 ATXN7L2 CLNK DNM1 ITSN1 KRTAP12-2 LGALS13 OGT PACSIN1 PACSIN2 PAK2 RAF1 SMARCD1 SOS1 SOS2 SPRY2 SYNJ1 TERF2IP TNFSF4 TNPO2 TRPV4 WASL	10 interacting genes: CERS2 COLGALT2 IL10 LTB4R PACSIN3 SMG7 SOAT1 TNFRSF4 TPR TRAF2
Entrez ID		29763	7292
HPRD ID		05937	04668
Ensembl ID		ENSG00000165912	ENSG00000117586
Uniprot IDs		Q9UKS6	A0A024R937 P23510
PDB IDs			2HEV
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Developmental Process Plasma Membrane Ruffle Membrane Synaptic Vesicle Endocytosis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Presynaptic Endocytosis Regulation Of Pro-B Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Glutamatergic Synapse Regulation Of Lymphoid Progenitor Cell Differentiation Regulation Of T Cell Differentiation Import Into Cell Insulin Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Plasma Membrane Tubulation Regulation Of Plasma Membrane Organization Cell Projection Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Lymphocyte Differentiation Vesicle-mediated Transport In Synapse Schwann Cell Development Endocytosis Protein Kinase Binding Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Protein Localization SH3 Domain Binding Regulation Of T Cell Differentiation In Thymus Establishment Of Organelle Localization Cytoplasmic Vesicle Vesicle Budding From Membrane Phosphatidylinositol-3,4,5-trisphosphate Binding Clathrin Coat Assembly Involved In Endocytosis Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Neurotrophin Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Establishment Of Localization In Cell Regulation Of Cell Differentiation Positive Regulation Of Cellular Component Organization Regulation Of Endocytosis Regulation Of Lymphocyte Activation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway B Cell Homeostasis Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation	Regulation Of Immunoglobulin Production Regulation Of Membrane Protein Ectodomain Proteolysis Leukotriene Signaling Pathway Leukotriene B4 Receptor Activity Leukotriene Receptor Activity Positive Regulation Of Immune Effector Process Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Involved In Immune Response Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of Chronic Inflammatory Response Regulation Of B Cell Proliferation Regulation Of Production Of Molecular Mediator Of Immune Response Negative Regulation Of Receptor Binding Regulation Of Protein Metabolic Process Interleukin-10 Receptor Binding Mononuclear Cell Proliferation Lymphocyte Activation Negative Regulation Of Interleukin-18 Production Positive Regulation Of Immunoglobulin Production Negative Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Lymphocyte Proliferation Response To Carbon Monoxide Negative Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of B Cell Apoptotic Process Negative Regulation Of Interferon-alpha Production Negative Regulation Of Cytokine Activity Positive Regulation Of B Cell Activation Regulation Of Cytokine Activity Positive Regulation Of Plasma Cell Differentiation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Cholesterol Storage Sterol O-acyltransferase Activity Cholesterol O-acyltransferase Activity RNA Export From Nucleus Nuclear Export Positive Regulation Of Chromatin Organization Negative Regulation Of RNA Export From Nucleus Positive Regulation Of Heterochromatin Formation MRNA Export From Nucleus MRNA Transport MRNA Export From Nucleus In Response To Heat Stress Nuclear Matrix Organization RNA Import Into Nucleus Sphingolipid Binding TORC2 Complex Disassembly Tumor Necrosis Factor-mediated Signaling Pathway TRAF2-GSTP1 Complex IRE1-TRAF2-ASK1 Complex TORC1 Complex Assembly CD40 Receptor Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?