MAGEH1 and ELN

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MAGEH1	ELN
Description		MAGE family member H1	elastin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Extracellular Region Extracellular Matrix Elastic Fiber
	Molecular Function	Protein Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process	Outflow Tract Morphogenesis Aortic Valve Morphogenesis Skeletal Muscle Tissue Development Respiratory Gaseous Exchange By Respiratory System Blood Circulation Animal Organ Morphogenesis Extracellular Matrix Organization Regulation Of Actin Filament Polymerization Stress Fiber Assembly Regulation Of Smooth Muscle Cell Proliferation Extracellular Matrix Assembly
Pathways			Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs			Rofecoxib
Diseases			Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome Congenital supravalvar aortic stenosis
GWAS		Smoking initiation ( 24665060)	Diverticular disease ( 30177863) Height ( 31562340)
Interacting Genes		16 interacting genes: APP CDK5RAP2 DYRK1A ELN HMBOX1 KPNA2 MOAP1 NAP1L5 NGFR PIAS4 SH2B2 TADA3 TNFRSF1A TNIP1 TRIM41 ZSCAN9	26 interacting genes: ALMS1 ARLN ASS1 ATP2A2 BGN CKMT2 CLU DCN ELANE FBLN1 FBLN2 FBN1 FBN2 FCN1 FKBP10 LGALS3 LOX LOXL1 LYZ MAGEH1 MFAP2 MTDH NID2 PLN PRTN3 SPINK1
Entrez ID		28986	2006
HPRD ID		06633	00556
Ensembl ID		ENSG00000187601	ENSG00000049540
Uniprot IDs		Q9H213	B3KRT8 B4E3S4 E7EN65 E7ENM0 G3V0G6 G5E950 P15502 Q59H17 Q6ZUN2 Q8NBI4
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Biosynthetic Process Central Nervous System Development Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Supramolecular Fiber Organization Non-canonical NF-kappaB Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Positive Regulation Of Inflammatory Response Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Defense Response Histone H3T45 Kinase Activity Hair Follicle Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cytokine-mediated Signaling Pathway Telomere-telomerase Complex Assembly Regulation Of Primary Metabolic Process Cellular Response To Amyloid-beta Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Cellular Response To Stress Tubulin Binding Response To Amyloid-beta Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Regulation Of Microtubule Polymerization Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Dorsal Aorta Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway	Extracellular Matrix Extracellular Region Extracellular Space Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity Microfibril Extracellular Matrix Organization Extracellular Structure Organization Calcium Ion-transporting ATPase Complex Sequestering Of TGFbeta In Extracellular Matrix Embryonic Eye Morphogenesis Basement Membrane Extracellular Matrix Binding Regulation Of Multicellular Organismal Process Calcium Ion Binding Protein-lysine 6-oxidase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Regulation Of Cardiac Muscle Cell Membrane Potential Humoral Immune Response Killing Of Cells Of Another Organism Fibrinogen Binding Post-embryonic Eye Morphogenesis Regulation Of Calcium Ion Import Sequestering Of Extracellular Ligand From Receptor Eye Morphogenesis Collagen Fibril Organization Extracellular Negative Regulation Of Signal Transduction Relaxation Of Cardiac Muscle Extracellular Matrix Structural Constituent Conferring Compression Resistance Sensory Organ Morphogenesis Cell Killing Negative Regulation Of Calcium Ion Import Azurophil Granule Lumen Relaxation Of Muscle Negative Regulation Of Heart Contraction Response To External Biotic Stimulus Extracellular Exosome Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Blood Circulation Glycosaminoglycan Binding Muscle Cell Cellular Homeostasis Regulation Of The Force Of Heart Contraction Defense Response To Symbiont Negative Regulation Of Signal Transduction Defense Response To Other Organism Extracellular Matrix Assembly Embryonic Organ Morphogenesis Fibronectin Binding Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Endocytosis
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