TRIB2 and SLAMF7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TRIB2	SLAMF7
Description		tribbles pseudokinase 2	SLAM family member 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Kinase Inhibitor Activity Protein Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Regulator Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Identical Protein Binding
	Biological Process	Protein Phosphorylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Interleukin-10 Production Regulation Of MAP Kinase Activity Negative Regulation Of Fat Cell Differentiation	Adaptive Immune Response Immune System Process Immune Response Cell Adhesion Natural Killer Cell Activation T Cell Activation Natural Killer Cell Mediated Cytotoxicity Innate Immune Response
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs			Elotuzumab
Diseases
GWAS		Age at first birth ( 34211149) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Cataracts ( 34127677) Chronotype ( 30696823) Dental caries ( 23064961) Diffusing capacity of carbon monoxide ( 30694715) Diisocyanate-induced asthma ( 25918132) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Graves' disease ( 22922229) Heel bone mineral density ( 30598549) joint destruction in rheumatoid arthritis (rapid vs slow) ( 33585033) Methadone dose in opioid dependence ( 28115739) Multiple sclerosis ( 24076602) Optic cup area ( 28073927 25631615) Pericardial adipose tissue adjusted for height and weight ( 27918534) Pericardial fat ( 27918534 22589742) Platelet count ( 32888494)	Blood protein levels ( 30072576) IgM levels ( 28628107) Inflammatory bowel disease ( 23128233) Microalbuminuria ( 26631737) Multiple sclerosis ( 24076602)
Interacting Genes		8 interacting genes: ACACA APP BTRC CEBPA PARVG PRMT6 SLAMF7 UBQLN4	11 interacting genes: ADRA2A API5 CLK3 MAK PANK1 PITX2 SH2D1A SVIL THRSP TMOD4 TRIB2
Entrez ID		28951	57823
HPRD ID		18224	09432
Ensembl ID		ENSG00000071575	ENSG00000026751
Uniprot IDs		Q92519	B4DVL7 B4DW98 Q9NQ25
PDB IDs		7UPM
Enriched GO Terms of Interacting Partners?		Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Histone H2AR3 Methyltransferase Activity Malonyl-CoA Biosynthetic Process Ligase Activity Protein Tetramerization Acetyl-CoA Carboxylase Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Negative Regulation Of Transcription By RNA Polymerase II Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Memory Notch Signaling Pathway Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization CHOP-C/EBP Complex Response To Vitamin B2 C/EBP Complex Negative Regulation Of Autophagy Protein Phosphorylated Amino Acid Binding Negative Regulation Of Catabolic Process Histone H3R2 Methyltransferase Activity Histone Arginine N-methyltransferase Activity Negative Regulation Of Autophagosome Maturation Nuclear Proteasome Complex Amide Biosynthetic Process Positive Regulation Of Catabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of RNA Biosynthetic Process	Cytoplasm Negative Regulation Of Uterine Smooth Muscle Contraction Alpha-1B Adrenergic Receptor Binding Alpha-2C Adrenergic Receptor Binding Phospholipase C-activating Adrenergic Receptor Signaling Pathway Protein Homodimerization Activity Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Protein Phosphorylation Negative Regulation Of Non-motile Cilium Assembly Skeletal Muscle Tissue Development Left Lung Morphogenesis Superior Vena Cava Morphogenesis Prolactin Secreting Cell Differentiation Cell Proliferation Involved In Outflow Tract Morphogenesis Pulmonary Vein Morphogenesis Subthalamic Nucleus Development Regulation Of Actin Filament Depolymerization Actin Filament Capping Negative Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Pantothenate Kinase Activity Regulation Of Protein Depolymerization Actin Filament-based Process Alpha2-adrenergic Receptor Activity Phosphorylation Pulmonary Myocardium Development Endodermal Digestive Tract Morphogenesis Deltoid Tuberosity Development Norepinephrine Binding Thermoception Somatotropin Secreting Cell Differentiation Cell Proliferation Involved In Heart Morphogenesis Acetyl-CoA Binding Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Negative Regulation Of Epinephrine Secretion Protein Kinase Activity Striated Muscle Tissue Development Embryonic Heart Tube Left/right Pattern Formation Muscle Structure Development Extraocular Skeletal Muscle Development Atrioventricular Valve Development Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Protein-containing Complex Assembly Ubiquitin-protein Transferase Regulator Activity Pointed-end Actin Filament Capping
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