MKNK2 and CUL2

Number of citations of the paper that reports this interaction (PubMedID 16856496)
0

Data Source:
BioGRID (two hybrid)

		MKNK2	CUL2
Description		MAPK interacting serine/threonine kinase 2	cullin 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body	Nucleus Nucleoplasm Nucleolus Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Nuclear Lumen
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Ubiquitin-protein Transferase Activity Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Ubiquitin Ligase Complex Scaffold Activity
	Biological Process	Regulation Of Translation Protein Phosphorylation Apoptotic Process Cell Surface Receptor Signaling Pathway Hemopoiesis Intracellular Signal Transduction Cellular Response To Arsenic-containing Substance Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway
Pathways			Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs		Fostamatinib
Diseases
GWAS		Nonsyndromic cleft lip with or without cleft palate ( 28087736)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		13 interacting genes: CUL2 EIF4E EIF4G1 ESR1 ESR2 MAPK1 MAPK14 MAPK8 MESD PSMA1 RBX1 RPL7A VBP1	36 interacting genes: ABI1 ARID1B CAND1 CCND1 CDC34 CHD3 COMMD1 COPS5 CREM DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 E2F1 ELOC FNIP1 FZD8 GJD4 GPS1 HSD17B7P2 KAT2A KHNYN MKNK2 NEDD8 RNF7 SAP130 SENP8 TRIP12 UBC UBE2D1 UBE2D3 UBE2M VHL ZER1 ZNF25 ZYG11B
Entrez ID		2872	8453
HPRD ID		05459	06786
Ensembl ID		ENSG00000099875	ENSG00000108094
Uniprot IDs		B3KS07 Q9HBH9	A0A0A0MTN0 A0A140VKB1 A0A8I5KVR3 B7Z1Y1 Q13617
PDB IDs		2AC3 2AC5 2HW7 6CJ5 6CJE 6CJH 6CJW 6CJY 6CK3 6CK6 6CKI 6JLR 8P9B 8XFM 9HRC	4WQO 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N 7PLO 8IJ1 8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV 8JE1 8JE2 8PQL 8Q7R 8QU8 8R5H 8RWZ 8RX0 8WDK 8WQA 8WQB 8WQC 8WQE 8WQF 8WQG 8WQH
Enriched GO Terms of Interacting Partners?		MAP Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Nuclear Estrogen Receptor Activity Enzyme Binding Cellular Response To Lipid Response To Lipid Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Response To Nutrient Levels Cellular Response To Oxygen-containing Compound MAPK Cascade Energy Homeostasis Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cellular Response To Nutrient Levels Estrogen Response Element Binding Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Eukaryotic Translation Initiation Factor 4F Complex Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Cullin-RING Ubiquitin Ligase Complex Nucleus Negative Regulation Of Autophagy Mammary Gland Epithelial Cell Proliferation Cul2-RING Ubiquitin Ligase Complex Positive Regulation Of Cyclase Activity Cytosol Nuclear Steroid Receptor Activity Peptidyl-threonine Phosphorylation Intracellular Signal Transduction Negative Regulation Of Catabolic Process Regulation Of Autophagy Estrogen Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process P38MAPK Cascade Mitotic Cell Cycle Phase Transition Response To UV Steroid Binding Regulation Of Inflammatory Response Cell Cycle Phase Transition Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Metabolic Process Canonical Inflammasome Complex Assembly Behavioral Fear Response Behavioral Defense Response Cellular Response To Estradiol Stimulus Cellular Response To Starvation Regulation Of MRNA Stability Macromolecule Metabolic Process	Protein Neddylation Post-translational Protein Modification Protein Modification By Small Protein Conjugation Regulation Of Protein Neddylation Protein Modification Process Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Protein Metabolic Process Cullin Family Protein Binding Proteolysis Involved In Protein Catabolic Process Regulation Of Post-translational Protein Modification Proteolysis Cul2-RING Ubiquitin Ligase Complex Regulation Of Primary Metabolic Process Ubiquitin Ligase Complex Nucleus Modification-dependent Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Macromolecule Metabolic Process Protein Ubiquitination Ubiquitin Conjugating Enzyme Binding Regulation Of Macromolecule Metabolic Process Protein Deneddylation Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Regulation Of Protein Modification Process Nucleoplasm Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Transcription By RNA Polymerase II Ubiquitin-protein Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Metabolic Process Macromolecule Catabolic Process NEDD8 Transferase Activity Ubiquitin Conjugating Enzyme Activity Proteasomal Protein Catabolic Process Positive Regulation Of Metabolic Process DeNEDDylase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Catabolic Process Protein Polyubiquitination Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Tag Activity
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