SSC5D and MED11

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SSC5D	MED11
Description		scavenger receptor cysteine rich family member with 5 domains	mediator complex subunit 11
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Membrane Extracellular Matrix	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex Core Mediator Complex
	Molecular Function	Fibronectin Binding Scavenger Receptor Activity Protein Binding Laminin Binding Extracellular Matrix Binding	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Immune System Process Defense Response Vesicle-mediated Transport Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-8 Production Detection Of Bacterial Lipoprotein Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium	Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		Scavenging by Class B Receptors	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions
Drugs
Diseases
GWAS		Height ( 28552196) Lung adenocarcinoma ( 28604730)
Interacting Genes		17 interacting genes: BLOC1S2 CEP170P1 DTNBP1 EXOC7 HAUS1 KRT27 MED11 MED21 MED29 NECAB2 NUP62 PIN1 SDCBP SEC23IP SKA1 TCEA2 TRAF1	14 interacting genes: ABI2 APP CCDC120 CFTR GCSH MED22 MED8 MED9 NDEL1 NME7 SGF29 SSC5D SYCE2 USHBP1
Entrez ID		284297	400569
HPRD ID		11444	14709
Ensembl ID		ENSG00000179954	ENSG00000161920
Uniprot IDs		A1L4H1	I3L3E8 Q9P086
PDB IDs			7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Elongation Core Mediator Complex Cytoskeleton Organization Cellular Component Assembly RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Elongation By RNA Polymerase II Mediator Complex Positive Regulation Of Mitotic Cytokinetic Process Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Transcription Preinitiation Complex Assembly Regulation Of Receptor Internalization Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Mitotic Cytokinesis Organelle Localization Regulation Of Cytokinesis Microtubule-based Process Regulation Of Mitotic Cytokinesis BLOC-1 Complex Negative Regulation Of Receptor Internalization Regulation Of Transcription Elongation By RNA Polymerase II Mitotic Spindle Microtubule Anterograde Synaptic Vesicle Transport Regulation Of Mitotic Nuclear Division Regulation Of Receptor-mediated Endocytosis Organelle Organization Transcription Coregulator Activity Platelet Dense Granule Organization Centrosome Regulation Of Nuclear Division Negative Regulation Of Receptor-mediated Endocytosis Flemming Body Regulation Of Microtubule Cytoskeleton Organization Synaptic Vesicle Transport Melanosome Organization Pigment Granule Organization Regulation Of Cell Division Midbody Protein-DNA Complex Assembly Positive Regulation Of Cytokinesis Microtubule Cytoskeleton Organization Anterograde Axonal Transport Cis-trans Isomerase Activity Interleukin-5 Receptor Complex Positive Regulation Of Mitotic Nuclear Division Mitotic Metaphase Chromosome Alignment Vesicle Transport Along Microtubule Establishment Of Protein Localization	Core Mediator Complex Mediator Complex RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Transcription Coregulator Activity Transport Along Microtubule Protein-DNA Complex Assembly Cytoskeleton-dependent Intracellular Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Microtubule-based Transport Amylin Binding Positive Regulation Of Toll Signaling Pathway Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Gene Expression, Epigenetic Cellular Response To CAMP Acetylcholine Receptor Activator Activity PTB Domain Binding Cell Projection Morphogenesis Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Axo-dendritic Transport Endosome To Plasma Membrane Transport Vesicle Cellular Component Assembly Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Defense Response To Gram-negative Bacterium Positive Regulation Of G Protein-coupled Receptor Internalization Response To CAMP Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport PDZ Domain Binding Glycine Decarboxylation Via Glycine Cleavage System Glycine Cleavage Complex Aminomethyltransferase Activity
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