MED11 and SYCE2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MED11	SYCE2
Description		mediator complex subunit 11	synaptonemal complex central element protein 2
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex Core Mediator Complex	Central Element Nucleus Nucleoplasm Chromosome
	Molecular Function	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Synaptonemal Complex Assembly Cell Division Meiotic Cell Cycle
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions	Meiotic synapsis
Drugs
Diseases
GWAS			Clozapine-induced agranulocytosis ( 25187353) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494)
Interacting Genes		14 interacting genes: ABI2 APP CCDC120 CFTR GCSH MED22 MED8 MED9 NDEL1 NME7 SGF29 SSC5D SYCE2 USHBP1	12 interacting genes: CCDC196 CDC37 GAD2 HOMER1 IFT20 KIFC3 MED11 NAP1L5 TEX12 TRIM69 TRIML2 TSNAX
Entrez ID		400569	256126
HPRD ID		14709	19522
Ensembl ID		ENSG00000161920	ENSG00000161860
Uniprot IDs		I3L3E8 Q9P086	Q6PIF2
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH	6R17 6YQF
Enriched GO Terms of Interacting Partners?		Core Mediator Complex Mediator Complex RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Transcription Coregulator Activity Transport Along Microtubule Protein-DNA Complex Assembly Cytoskeleton-dependent Intracellular Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Microtubule-based Transport Amylin Binding Positive Regulation Of Toll Signaling Pathway Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Gene Expression, Epigenetic Cellular Response To CAMP Acetylcholine Receptor Activator Activity PTB Domain Binding Cell Projection Morphogenesis Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Axo-dendritic Transport Endosome To Plasma Membrane Transport Vesicle Cellular Component Assembly Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Defense Response To Gram-negative Bacterium Positive Regulation Of G Protein-coupled Receptor Internalization Response To CAMP Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport PDZ Domain Binding Glycine Decarboxylation Via Glycine Cleavage System Glycine Cleavage Complex Aminomethyltransferase Activity
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