SMIM21 and DESI1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SMIM21	DESI1
Description		small integral membrane protein 21	desumoylating isopeptidase 1
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Nucleus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Protein Binding	Protein Binding Peptidase Activity Palmitoyl-(protein) Hydrolase Activity Hydrolase Activity DeSUMOylase Activity Identical Protein Binding Long-chain Fatty Acyl-CoA Hydrolase Activity Importin-alpha Family Protein Binding
	Biological Process		Proteolysis Protein Export From Nucleus Protein Desumoylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Macromolecule Depalmitoylation
Pathways
Drugs
Diseases
GWAS		Chronotype ( 30696823) Rheumatoid arthritis (ACPA-negative) ( 24532677) Serum uric acid levels in response to allopurinol in gout ( 25676789) Tenofovir clearance in HIV infection ( 26148204)	General cognitive ability ( 29844566) Meat-related diet ( 32066663) Neuroticism ( 29255261) Refractive error ( 32231278)
Interacting Genes		2 interacting genes: CFTR DESI1	35 interacting genes: ABI3 AGR3 CCDC158 CDIP1 CDSN CENPM CTAG1A CTAG1B CTAG2 DAZAP2 ERP29 EVI2B FGF7 GOLM1 KLRF1 MEOX2 NME3 NT5C3A PRR5 RBX1 RNF4 RPS27A SHISA4 SHISA5 SLC25A17 SMIM21 TAS2R41 UBA52 UBB UBC UBQLN1 UBQLNL UHRF2 XPO1 ZBTB46
Entrez ID		284274	27351
HPRD ID		18769	18590
Ensembl ID		ENSG00000206026	ENSG00000100418
Uniprot IDs		J3KSN8 Q3B7S5	Q6ICB0
PDB IDs			3EBQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Amelogenesis Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization ATPase-coupled Inorganic Anion Transmembrane Transporter Activity DeSUMOylase Activity Importin-alpha Family Protein Binding Palmitoyl-(protein) Hydrolase Activity Protein Desumoylation Macromolecule Depalmitoylation Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Long-chain Fatty Acyl-CoA Hydrolase Activity Cellular Response To Forskolin Response To Forskolin Protein-containing Complex Chloride Transmembrane Transporter Activity Sperm Capacitation Bicarbonate Transport Water Transport Macromolecule Deacylation Multicellular Organismal-level Water Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Transepithelial Transport Protein Export From Nucleus Vesicle Docking Involved In Exocytosis Positive Regulation Of Transporter Activity ABC-type Transporter Activity Sterol Biosynthetic Process Chloride Channel Complex Positive Regulation Of Biomineral Tissue Development Cellular Response To CAMP Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Vesicle Docking	Protein Tag Activity TRNA Threonylcarbamoyladenosine Metabolic Process Modification-dependent Protein Catabolic Process Endocytic Vesicle Membrane Ubiquitin Protein Ligase Binding Mitochondrial Outer Membrane Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Regulation Of Granulocyte Differentiation Protein Modification By Small Protein Conjugation Vesicle
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