GNG10 and GNB4

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, pull down)

		GNG10	GNB4
Description		G protein subunit gamma 10	G protein subunit beta 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Membrane	Cytoplasm Lysosomal Membrane Cytosol Heterotrimeric G-protein Complex Synapse Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding G-protein Beta-subunit Binding	Protein Binding Signaling Receptor Complex Adaptor Activity Protein-containing Complex Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway	Signal Transduction G Protein-coupled Receptor Signaling Pathway Substantia Nigra Development
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases
GWAS			Atrial fibrillation ( 29892015 30061737) Heart rate ( 23583979) Resting heart rate ( 27798624 29769521)
Interacting Genes		8 interacting genes: GNB1 GNB2 GNB4 KRT16 KRT31 KRT34 KRT38 TCF4	18 interacting genes: GNAI1 GNAI2 GNAI3 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNGT1 GNGT2 MTNR1A MTNR1B PTEN UBC
Entrez ID		2790	59345
HPRD ID		10374	09973
Ensembl ID		ENSG00000242616	ENSG00000114450
Uniprot IDs		P50151	Q9HAV0
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Signaling Receptor Complex Adaptor Activity Heterotrimeric G-protein Complex Intermediate Filament Structural Molecule Activity Morphogenesis Of An Epithelium Epithelial Cell Differentiation Tissue Morphogenesis Epidermis Development Supramolecular Fiber Organization Extracellular Exosome GTPase Binding Protein-containing Complex Binding Lysosomal Membrane Cytoskeleton Organization Structural Constituent Of Cytoskeleton Developmental Process Beta-catenin-TCF7L2 Complex Cytosol Cell Differentiation TFIIB-class Transcription Factor Binding Cytoskeleton Keratinocyte Migration Anatomical Structure Morphogenesis Tissue Development G Protein-coupled Receptor Signaling Pathway Cellular Developmental Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Beta-catenin-TCF Complex Hair Cycle Synapse Cellular Response To Catecholamine Stimulus GTPase Activity Cellular Response To Prostaglandin E Stimulus Response To Catecholamine G Protein-coupled Acetylcholine Receptor Signaling Pathway Photoreceptor Disc Membrane G Protein-coupled Dopamine Receptor Signaling Pathway Cellular Response To Prostaglandin Stimulus	Heterotrimeric G-protein Complex G-protein Beta-subunit Binding G Protein-coupled Receptor Signaling Pathway GTPase Activity Plasma Membrane Signal Transduction Guanyl Nucleotide Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Membrane Synapse Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Melatonin Receptor Activity Negative Regulation Of Adenylate Cyclase Activity G Protein-coupled Receptor Binding PDZ Domain Binding Extracellular Exosome Response To Prostaglandin E Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Secretion By Cell Regulation Of G Protein-coupled Receptor Signaling Pathway Reproductive Behavior Negative Regulation Of Secretion Phototransduction Negative Regulation Of Insulin Secretion Midbody Negative Regulation Of Transport Negative Regulation Of Peptide Secretion Negative Regulation Of Synaptic Vesicle Clustering G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Detection Of Light Stimulus Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Negative Regulation Of Hormone Secretion Multicellular Organismal Response To Stress Negative Regulation Of Protein Secretion Regulation Of Vascular Associated Smooth Muscle Cell Proliferation D2 Dopamine Receptor Binding GDP Binding Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Cell Body Ciliary Basal Body Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep
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