GNG10 and KRT16

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GNG10	KRT16
Description		G protein subunit gamma 10	keratin 16
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Membrane	Cornified Envelope Nucleus Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding G-protein Beta-subunit Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway	Morphogenesis Of An Epithelium Inflammatory Response Cytoskeleton Organization Keratinocyte Differentiation Negative Regulation Of Cell Migration Keratinization Hair Cycle Innate Immune Response Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Keratinocyte Migration Establishment Of Skin Barrier
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Keratinization Formation of the cornified envelope
Drugs			Zinc Zinc acetate
Diseases			Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex Non-epidermolytic palmoplantar keratoderma (NEPPK)
GWAS
Interacting Genes		8 interacting genes: GNB1 GNB2 GNB4 KRT16 KRT31 KRT34 KRT38 TCF4	53 interacting genes: AIRIM AMOT ARFIP2 C1orf216 CARD9 CCDC146 CCDC17 CCHCR1 CCNC CDK18 CYTH4 DRC4 EPM2AIP1 GNG10 HGS KIFC3 KLC4 KRT1 KRT6C KRT71 KRT72 KRT73 KRT74 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 LMO1 LNX1 MBD3 PKN1 POLL PPP1R18 PRKAA2 PRPH PUS10 SEMA4C SGF29 SMARCD1 SMARCE1 SNAPIN TCHP TSG101 TTC23 TXLNB USHBP1
Entrez ID		2790	3868
HPRD ID		10374	01018
Ensembl ID		ENSG00000242616	ENSG00000186832
Uniprot IDs		P50151	P08779
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Signaling Receptor Complex Adaptor Activity Heterotrimeric G-protein Complex Intermediate Filament Structural Molecule Activity Morphogenesis Of An Epithelium Epithelial Cell Differentiation Tissue Morphogenesis Epidermis Development Supramolecular Fiber Organization Extracellular Exosome GTPase Binding Protein-containing Complex Binding Lysosomal Membrane Cytoskeleton Organization Structural Constituent Of Cytoskeleton Developmental Process Beta-catenin-TCF7L2 Complex Cytosol Cell Differentiation TFIIB-class Transcription Factor Binding Cytoskeleton Keratinocyte Migration Anatomical Structure Morphogenesis Tissue Development G Protein-coupled Receptor Signaling Pathway Cellular Developmental Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Beta-catenin-TCF Complex Hair Cycle Synapse Cellular Response To Catecholamine Stimulus GTPase Activity Cellular Response To Prostaglandin E Stimulus Response To Catecholamine G Protein-coupled Acetylcholine Receptor Signaling Pathway Photoreceptor Disc Membrane G Protein-coupled Dopamine Receptor Signaling Pathway Cellular Response To Prostaglandin Stimulus	Intermediate Filament Organization Keratin Filament Structural Constituent Of Skin Epidermis Keratinization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Supramolecular Fiber Organization Cytoskeleton Organization Organelle Organization Protein Binding Cytosol
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