GM2A and EPHB1

		GM2A	EPHB1
Description		ganglioside GM2 activator	EPH receptor B1
Image
GO Annotations	Cellular Component	Extracellular Region Lysosome Cytosol Cytoplasmic Side Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Extracellular Region Cytoplasm Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Axon Dendrite Early Endosome Membrane Filopodium Tip Cell Projection Membrane Raft Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Beta-N-acetylhexosaminidase Activity Lipid Transporter Activity Protein Binding Enzyme Activator Activity Phospholipase Activator Activity Hydrolase Activity Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Kinase Activity Transferase Activity Protein-containing Complex Binding
	Biological Process	Ganglioside Metabolic Process Lipid Metabolic Process Sphingolipid Metabolic Process Ganglioside Catabolic Process Lipid Transport Learning Or Memory Oligosaccharide Catabolic Process Lipid Storage Glycosphingolipid Catabolic Process Nervous System Process Neuromuscular Process Controlling Balance	Angiogenesis Immunological Synapse Formation Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Skeletal Muscle Satellite Cell Activation Cell Migration Cranial Nerve Development Optic Nerve Morphogenesis Hindbrain Tangential Cell Migration Central Nervous System Projection Neuron Axonogenesis Neurogenesis Establishment Of Cell Polarity Retinal Ganglion Cell Axon Guidance Cell-substrate Adhesion Regulation Of JNK Cascade Protein Autophosphorylation Ephrin Receptor Signaling Pathway Camera-type Eye Morphogenesis System Development Modulation Of Chemical Synaptic Transmission Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Synapse Assembly Cell Chemotaxis Dendritic Spine Development Dendritic Spine Morphogenesis Neural Precursor Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation
Pathways		Neutrophil degranulation Glycosphingolipid catabolism	EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs		Platelet Activating Factor Lauric acid Lpc-Ether Choline alfoscerate Myristic acid	Chlortetracycline Fostamatinib
Diseases		GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant
GWAS		Bulimia nervosa ( 23568457) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Serum folate levels ( 29953918)	A body shape index ( 34021172) Adult body size ( 32376654) Bitter beverage consumption ( 31046077) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Daytime sleep phenotypes ( 27126917) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Familial lung adenocarcinoma ( 29924316) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Mood instability ( 31168069) Neurofibrillary tangles ( 31497858) Small cell lung carcinoma ( 28604730) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist circumference adjusted for body mass index ( 34021172) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		5 interacting genes: EPHB1 GPLD1 HEXA LCOR PLD2	23 interacting genes: AADAC ACP1 ACP3 AMOTL2 CTPS1 EFNA1 EFNA5 EFNB1 EFNB2 EPHB6 ERBB2 GM2A GRB10 GRB2 GTF2E1 MBD4 MRPL3 MTDH NCK1 PCCB PRKCG PXN UQCRC2
Entrez ID		2760	2047
HPRD ID		02034	02790
Ensembl ID		ENSG00000196743	ENSG00000154928
Uniprot IDs		P17900	P54762
PDB IDs		1G13 1PU5 1PUB 1TJJ 2AF9 2AG2 2AG4 2AG9	2DJS 2EAO 3ZFX 5MJA 5MJB 6UMW 7KPL 7KPM
Enriched GO Terms of Interacting Partners?		Phospholipase D Activity Positive Regulation Of Alkaline Phosphatase Activity Glycosylphosphatidylinositol Phospholipase D Activity Filopodium Tip Optic Nerve Morphogenesis Phosphate-containing Compound Metabolic Process Regulation Of Skeletal Muscle Cell Proliferation Transmembrane-ephrin Receptor Activity Negative Regulation Of Skeletal Muscle Cell Differentiation Detection Of Temperature Stimulus Negative Regulation Of Skeletal Muscle Cell Proliferation Cell Migration In Hindbrain Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Skeletal Muscle Cell Differentiation Axon Guidance Receptor Activity Negative Regulation Of Satellite Cell Differentiation Immunological Synapse Formation Detection Of Temperature Stimulus Involved In Sensory Perception Cranial Nerve Morphogenesis Hindbrain Tangential Cell Migration Dendritic Spine Development Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Retinal Ganglion Cell Axon Guidance Dendritic Spine Morphogenesis Regulation Of Skeletal Muscle Satellite Cell Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Activity Skeletal Muscle Satellite Cell Activation Lipid Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Response To Sterol Positive Regulation Of Triglyceride Metabolic Process Positive Regulation Of Phosphatase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Triglyceride Biosynthetic Process Glycerophospholipid Metabolic Process Regulation Of Dephosphorylation Negative Regulation Of Triglyceride Catabolic Process Phospholipid Metabolic Process Response To Triglyceride Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Triglyceride Metabolic Process Hematopoietic Stem Cell Migration Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Triglyceride Biosynthetic Process Cellular Response To Triglyceride Positive Regulation Of Dephosphorylation Immune Response-activating Signaling Pathway Positive Regulation Of High-density Lipoprotein Particle Clearance Activation Of Immune Response	Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Neuron Projection Guidance Axon Guidance Cell Surface Receptor Signaling Pathway Vesicle Membrane Acid Phosphatase Activity Neuron Projection Development Neurotrophin TRKA Receptor Binding T Cell Costimulation T Cell Activation Regulation Of Cell-cell Adhesion Signal Complex Assembly Regulation Of Cell Adhesion Plasma Membrane Bounded Cell Projection Organization Pyrimidine-containing Compound Metabolic Process T Cell Proliferation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Cell-cell Junction Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Schwann Cell Development Lymphocyte Activation Positive Regulation Of Phosphorylation Positive Regulation Of T Cell Activation Cell Projection Organization Positive Regulation Of Cell Adhesion Lymphocyte Proliferation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Lymphocyte Activation Mononuclear Cell Proliferation Leukocyte Activation Positive Regulation Of Phosphate Metabolic Process Presynaptic Membrane Leukocyte Proliferation Cell Migration Positive Regulation Of Cell-cell Adhesion Insulin-like Growth Factor Receptor Signaling Pathway Signaling Receptor Complex Adaptor Activity Positive Regulation Of Lymphocyte Activation Regulation Of Actin Cytoskeleton Organization Thiamine Phosphate Phosphatase Activity Signal Transduction Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity Guanyl-nucleotide Exchange Factor Adaptor Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?