GM2A

Description		ganglioside GM2 activator
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GO Annotations	Cellular Component	Extracellular Region Lysosome Cytosol Cytoplasmic Side Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Beta-N-acetylhexosaminidase Activity Lipid Transporter Activity Protein Binding Enzyme Activator Activity Phospholipase Activator Activity Hydrolase Activity Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity
	Biological Process	Ganglioside Metabolic Process Lipid Metabolic Process Sphingolipid Metabolic Process Ganglioside Catabolic Process Lipid Transport Learning Or Memory Oligosaccharide Catabolic Process Lipid Storage Glycosphingolipid Catabolic Process Nervous System Process Neuromuscular Process Controlling Balance
Pathways		Neutrophil degranulation Glycosphingolipid catabolism
Drugs		Platelet Activating Factor Lauric acid Lpc-Ether Choline alfoscerate Myristic acid
Diseases		GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant
GWAS		Bulimia nervosa ( 23568457) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Serum folate levels ( 29953918)
Novel Interacting Genes		5 novel interacting genes: EPHB1 GPLD1 HEXA LCOR PLD2
Interacting Genes		5 interacting genes: EPHB1 GPLD1 HEXA LCOR PLD2
Entrez ID		2760
HPRD ID		02034
Ensembl ID		ENSG00000196743
Uniprot IDs		P17900
PDB IDs		1G13 1PU5 1PUB 1TJJ 2AF9 2AG2 2AG4 2AG9
Enriched GO Terms of Interacting Partners?		Phospholipase D Activity Positive Regulation Of Alkaline Phosphatase Activity Glycosylphosphatidylinositol Phospholipase D Activity Filopodium Tip Optic Nerve Morphogenesis Phosphate-containing Compound Metabolic Process Regulation Of Skeletal Muscle Cell Proliferation Transmembrane-ephrin Receptor Activity Negative Regulation Of Skeletal Muscle Cell Differentiation Detection Of Temperature Stimulus Negative Regulation Of Skeletal Muscle Cell Proliferation Cell Migration In Hindbrain Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Skeletal Muscle Cell Differentiation Axon Guidance Receptor Activity Negative Regulation Of Satellite Cell Differentiation Immunological Synapse Formation Detection Of Temperature Stimulus Involved In Sensory Perception Cranial Nerve Morphogenesis Hindbrain Tangential Cell Migration Dendritic Spine Development Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Retinal Ganglion Cell Axon Guidance Dendritic Spine Morphogenesis Regulation Of Skeletal Muscle Satellite Cell Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Activity Skeletal Muscle Satellite Cell Activation Lipid Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Response To Sterol Positive Regulation Of Triglyceride Metabolic Process Positive Regulation Of Phosphatase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Triglyceride Biosynthetic Process Glycerophospholipid Metabolic Process Regulation Of Dephosphorylation Negative Regulation Of Triglyceride Catabolic Process Phospholipid Metabolic Process Response To Triglyceride Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Triglyceride Metabolic Process Hematopoietic Stem Cell Migration Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Triglyceride Biosynthetic Process Cellular Response To Triglyceride Positive Regulation Of Dephosphorylation Immune Response-activating Signaling Pathway Positive Regulation Of High-density Lipoprotein Particle Clearance Activation Of Immune Response
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