PCLO and ERC2

Number of citations of the paper that reports this interaction (PubMedID 14734538)
38

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		PCLO	ERC2
Description		piccolo presynaptic cytomatrix protein	ELKS/RAB6-interacting/CAST family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoskeleton Postsynaptic Density Axon Cell Projection Organelle Synapse Presynaptic Active Zone Cytoskeleton Of Presynaptic Active Zone Extracellular Exosome Glutamatergic Synapse GABA-ergic Synapse	Cytoplasm Cytoskeleton Growth Cone Presynaptic Membrane Cell Projection Synapse Presynaptic Active Zone Presynapse Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Calcium Ion Binding Profilin Binding Calcium-dependent Phospholipid Binding Zinc Ion Binding Metal Ion Binding Structural Constituent Of Presynaptic Active Zone	Protein Binding Structural Constituent Of Presynaptic Active Zone
	Biological Process	Cytoskeleton Organization Synaptic Vesicle Exocytosis Regulation Of Exocytosis Insulin Secretion Protein Localization To Synapse Maintenance Of Presynaptic Active Zone Structure Regulation Of Transport Regulation Of Biological Quality Synaptic Vesicle Clustering Presynaptic Actin Cytoskeleton Organization Presynapse Organization Presynaptic Active Zone Assembly	Synaptic Vesicle Priming Maintenance Of Presynaptic Active Zone Structure Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Calcium-dependent Activation Of Synaptic Vesicle Fusion
Pathways		Sensory processing of sound by inner hair cells of the cochlea
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Energy expenditure (24h) ( 28476931) Grapefruit juice consumption ( 31046077) HDL cholesterol levels in HIV infection ( 33109212) Major depressive disorder ( 20351715 21621269 28540843) Metabolite levels ( 23823483) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Refractive error ( 32231278) Rosacea symptom severity ( 29771307) Schizophrenia ( 33169155)	Acute lymphoblastic leukemia (childhood) ( 22076464) Adult body size ( 32376654) Alcohol dependence ( 24166409) Bipolar disorder and schizophrenia ( 21057379) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 26955885) Cortical surface area (MOSTest) ( 32665545) Daytime sleep phenotypes ( 27126917) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549 28869591) Hip bone size ( 31053729) Hip circumference adjusted for BMI ( 34021172) Hip geometry ( 17903296) Intertrochanteric region size ( 31053729) Lateral thalamic nuclei volume ( 34006833) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Morning vs. evening chronotype ( 26955885 27494321) Night sleep phenotypes ( 27126917) Periodontitis (Mean PAL) ( 24024966) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Sense of smell ( 26632684) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tourette syndrome ( 30818990) Trochanter size ( 31053729)
Interacting Genes		6 interacting genes: ERC2 GIT1 GIT2 PCAT1 SNCA TMEM132D	10 interacting genes: BSN HNF1B MYB NRIP1 PCLO PPFIA1 PPFIA2 PPFIA3 PPFIA4 RIMS1
Entrez ID		27445	26059
HPRD ID		16078	10810
Ensembl ID		ENSG00000186472	ENSG00000187672
Uniprot IDs		Q9Y6V0	H7C4G9 O15083
PDB IDs		1UJD
Enriched GO Terms of Interacting Partners?		Presynapse Regulation Of G Protein-coupled Receptor Signaling Pathway Synaptic Vesicle Priming Growth Cone Synaptic Vesicle Recycling Regulation Of ARF Protein Signal Transduction Maintenance Of Synapse Structure Regulation Of Vesicle Fusion Synapse Organization Synapse Cell Junction Maintenance Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Neurotransmitter Secretion Positive Regulation Of SNARE Complex Assembly Regulation Of Microtubule Polymerization Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Cell Junction Organization Cellular Component Maintenance Negative Regulation Of ARF Protein Signal Transduction Regulation Of Microtubule Polymerization Or Depolymerization GABA-ergic Synapse Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Regulation Of Vesicle-mediated Transport Regulation Of Calcium-dependent Activation Of Synaptic Vesicle Fusion Structural Constituent Of Postsynaptic Specialization Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Dopamine Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Serotonin Uptake Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Regulation Of Exocytosis Locomotory Behavior Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Protein-containing Complex Assembly Intramembranous Ossification Response To Iron(II) Ion Calcium Ion Homeostasis Structural Constituent Of Presynaptic Active Zone Motor Learning Regulation Of Chaperone-mediated Autophagy Postsynapse Regulation Of Dopamine Uptake Involved In Synaptic Transmission	Presynaptic Active Zone Synapse Organization Cell Junction Organization Maintenance Of Synapse Structure Structural Constituent Of Presynaptic Active Zone Maintenance Of Presynaptic Active Zone Structure Cell Junction Maintenance Presynaptic Active Zone Organization Cellular Component Maintenance Cytoskeleton Of Presynaptic Active Zone Synaptic Vesicle Exocytosis Presynaptic Active Zone Assembly Signal Release Organelle Localization Synapse Synaptic Vesicle Docking Presynaptic Active Zone Cytoplasmic Component Vesicle-mediated Transport In Synapse Synaptic Vesicle Clustering Regulated Exocytosis Vesicle Localization Secretion By Cell Presynapse Organization Axon Modulation Of Chemical Synaptic Transmission Secretion Regulation Of Exocytosis Regulation Of Vesicle-mediated Transport Exocytosis Organelle Glutamatergic Synapse Regulation Of Secretion By Cell Vesicle Docking Involved In Exocytosis Regulation Of Secretion Insulin Secretion Postsynaptic Density Regulation Of Synaptic Vesicle Exocytosis Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Ovarian Follicle Rupture Structural Constituent Of Presynapse Vesicle Docking Epididymosome Protein Localization To Synapse Peptide Hormone Secretion Peptide Secretion Organelle Localization By Membrane Tethering
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