HTRA2 and CAD

Number of citations of the paper that reports this interaction (PubMedID 17266347)
0

Data Source:
BioGRID (unspecified method)

		HTRA2	CAD
Description		HtrA serine peptidase 2	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
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GO Annotations	Cellular Component	Chromatin Nucleus Mitochondrion Mitochondrial Intermembrane Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane Membrane Mitochondrial Membrane Protein-containing Complex CD40 Receptor Complex Serine-type Endopeptidase Complex	Nucleus Cytoplasm Cytosol Membrane Nuclear Matrix Protein-containing Complex Cell Projection Neuronal Cell Body Terminal Bouton Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Protein Serine/threonine Kinase Inhibitor Activity Identical Protein Binding Unfolded Protein Binding Ubiquitin Ligase Inhibitor Activity	Nucleotide Binding Catalytic Activity Aspartate Carbamoyltransferase Activity Carbamoyl-phosphate Synthase (ammonia) Activity Carbamoyl-phosphate Synthase (glutamine-hydrolyzing) Activity Dihydroorotase Activity Glutaminase Activity Protein Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Amino Acid Binding Transferase Activity Carboxyl- Or Carbamoyltransferase Activity Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Ligase Activity Enzyme Binding Identical Protein Binding Metal Ion Binding Aspartate Binding
	Biological Process	Proteolysis Ceramide Metabolic Process Apoptotic Process Mitochondrion Organization Adult Walking Behavior Adult Locomotory Behavior Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Herbicide Programmed Cell Death Protein Autoprocessing Pentacyclic Triterpenoid Metabolic Process Protein Catabolic Process Forebrain Development Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Interferon-beta Intracellular Signal Transduction Mitochondrial Protein Catabolic Process Regulation Of Multicellular Organism Growth Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Cycle Neuron Development Neuron Apoptotic Process Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Type 2 Mitophagy Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Liver Development 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process UDP Biosynthetic Process UTP Biosynthetic Process Amino Acid Metabolic Process Glutamine Metabolic Process Phosphate-containing Compound Metabolic Process Xenobiotic Metabolic Process Heart Development Female Pregnancy Lactation Response To Amine Citrulline Biosynthetic Process Response To Caffeine Animal Organ Regeneration Response To Insulin Response To Testosterone Response To Starvation 'de Novo' UMP Biosynthetic Process Response To Cortisol Nucleobase-containing Small Molecule Metabolic Process Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus Pyrimidine-containing Compound Biosynthetic Process
Pathways		Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt)	Pyrimidine biosynthesis
Drugs			Sparfosic acid
Diseases		Parkinson's disease (PD)
GWAS			Triglyceride levels ( 32203549)
Interacting Genes		41 interacting genes: ACTA1 ALDH1A2 APC APP AREL1 BIRC2 BIRC3 BIRC6 BIRC7 CAD CCAR2 CDK1 CDK5 CSN1S1 CSN2 DIABLO EEF1A1 EIF4G1 HSD17B10 IMMT ITGA7 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MUL1 PAG1 PDXDC1 PDXDC2P-NPIPB14P PEA15 TRIM28 TUBA1A TUBB TUBB6 TUBB7P UBC USP7 VIM VPS4B XIAP	14 interacting genes: CASP3 CEBPA HTRA2 LTBP1 MAPK1 NEDD4 PPP1CA PPP2CA PRKACA PTEN RAD9A SUMO2 XIAP YWHAG
Entrez ID		27429	790
HPRD ID		05919	06437
Ensembl ID		ENSG00000115317	ENSG00000084774
Uniprot IDs		A0A384MDW9 A0A8Q3SIX7 O43464	F8VPD4 P27708
PDB IDs		1LCY 2PZD 5FHT 5M3N 5M3O 5TNY 5TNZ 5TO0 5TO1 5WYN 7VGE 8AUK 8E2K	4BY3 4C6B 4C6C 4C6D 4C6E 4C6F 4C6I 4C6J 4C6K 4C6L 4C6M 4C6N 4C6O 4C6P 4C6Q 5G1N 5G1O 5G1P 5YNZ 6HFD 6HFE 6HFF 6HFH 6HFI 6HFJ 6HFK 6HFL 6HFN 6HFP 6HFQ 6HFR 6HFS 6HFU 6HG1 8GVZ 8GW0 8PBE 8PBG 8PBH 8PBI 8PBJ 8PBK 8PBM 8PBN 8PBP 8PBQ 8PBR 8PBS 8PBT 8PBU 9FS1 9FS2 9FS3
Enriched GO Terms of Interacting Partners?		Cell Death Apoptotic Process Programmed Cell Death MAP Kinase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process MAPK Cascade Regulation Of Cell Cycle Ubiquitin-protein Transferase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Cytosol Intracellular Signal Transduction Ubiquitin Protein Ligase Activity Protein Kinase Activity Regulation Of Apoptotic Process Intracellular Signaling Cassette Structural Constituent Of Cytoskeleton Regulation Of Programmed Cell Death Response To Cytokine Response To Peptide Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Inflammatory Response Acetylcholine Receptor Activator Activity Cytoplasm Response To Light Stimulus Positive Regulation Of Post-translational Protein Modification Glial Cell Development Protein Serine Kinase Activity Post-translational Protein Modification Regulation Of Post-translational Protein Modification Nucleotide Binding P38MAPK Cascade Protein Modification By Small Protein Conjugation Regulation Of Protein Metabolic Process Regulation Of Intracellular Transport Protein Serine/threonine Kinase Activity Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Growth Regulation Of Synapse Organization Response To Radiation DNA Damage Response Protein Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Developmental Growth Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Modification Process	Cellular Response To Stress Intracellular Signal Transduction Regulation Of Protein Metabolic Process Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Stress Regulation Of Cell Cycle RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Macromolecule Metabolic Process Protein Metabolic Process Regulation Of Signal Transduction DNA Damage Response Execution Phase Of Apoptosis Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Negative Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Response To Metal Ion Negative Regulation Of Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Cell Cycle Macromolecule Catabolic Process Negative Regulation Of Phosphate Metabolic Process Regulation Of Protein Stability Positive Regulation Of Signal Transduction Regulation Of Macroautophagy Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Carbohydrate Catabolic Process Nucleus Protein Domain Specific Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Protein Catabolic Process Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Positive Regulation Of Metabolic Process Learning Or Memory Glutamatergic Synapse Regulation Of Phosphorus Metabolic Process Vascular Endothelial Cell Response To Fluid Shear Stress Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Neuron Apoptotic Process Regulation Of Gene Expression Cognition Response To Lead Ion
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