HTRA2 and CCAR2

Number of citations of the paper that reports this interaction (PubMedID 17266347)
0

Data Source:
BioGRID (unspecified method, enzymatic study)

		HTRA2	CCAR2
Description		HtrA serine peptidase 2	cell cycle and apoptosis regulator 2
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GO Annotations	Cellular Component	Chromatin Nucleus Mitochondrion Mitochondrial Intermembrane Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane Membrane Mitochondrial Membrane Protein-containing Complex CD40 Receptor Complex Serine-type Endopeptidase Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Spindle Cytoskeleton DBIRD Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Protein Serine/threonine Kinase Inhibitor Activity Identical Protein Binding Unfolded Protein Binding Ubiquitin Ligase Inhibitor Activity	Adenyl-nucleotide Exchange Factor Activity RNA Polymerase II Complex Binding RNA Binding Enzyme Inhibitor Activity Protein Binding Enzyme Binding Unfolded Protein Binding
	Biological Process	Proteolysis Ceramide Metabolic Process Apoptotic Process Mitochondrion Organization Adult Walking Behavior Adult Locomotory Behavior Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Herbicide Programmed Cell Death Protein Autoprocessing Pentacyclic Triterpenoid Metabolic Process Protein Catabolic Process Forebrain Development Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Interferon-beta Intracellular Signal Transduction Mitochondrial Protein Catabolic Process Regulation Of Multicellular Organism Growth Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Cycle Neuron Development Neuron Apoptotic Process Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Type 2 Mitophagy Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Regulation Of DNA-templated Transcription MRNA Processing Apoptotic Process DNA Damage Response RNA Splicing Response To UV Wnt Signaling Pathway Negative Regulation Of Cell Growth Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Elongation Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Mitochondrial Fragmentation Involved In Apoptotic Process Negative Regulation Of DNA-templated Transcription Rhythmic Process Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Deacetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of DNA Damage Checkpoint
Pathways		Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt)	Regulation of HSF1-mediated heat shock response
Drugs
Diseases		Parkinson's disease (PD)
GWAS			Haemorrhoidal disease ( 33888516)
Interacting Genes		41 interacting genes: ACTA1 ALDH1A2 APC APP AREL1 BIRC2 BIRC3 BIRC6 BIRC7 CAD CCAR2 CDK1 CDK5 CSN1S1 CSN2 DIABLO EEF1A1 EIF4G1 HSD17B10 IMMT ITGA7 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MUL1 PAG1 PDXDC1 PDXDC2P-NPIPB14P PEA15 TRIM28 TUBA1A TUBB TUBB6 TUBB7P UBC USP7 VIM VPS4B XIAP	20 interacting genes: AR BAG2 CEBPA FMR1 FXR1 FXR2 HTRA2 IKBKB MAILR MALAT1 MYC NLGN3 RNF10 SIAH2 SIRT1 SUCLG1 SUMO2 TRIM28 WDR3 ZNF335
Entrez ID		27429	57805
HPRD ID		05919	09159
Ensembl ID		ENSG00000115317	ENSG00000158941
Uniprot IDs		A0A384MDW9 A0A8Q3SIX7 O43464	Q8N163
PDB IDs		1LCY 2PZD 5FHT 5M3N 5M3O 5TNY 5TNZ 5TO0 5TO1 5WYN 7VGE 8AUK 8E2K	8EZ6
Enriched GO Terms of Interacting Partners?		Cell Death Apoptotic Process Programmed Cell Death MAP Kinase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process MAPK Cascade Regulation Of Cell Cycle Ubiquitin-protein Transferase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Cytosol Intracellular Signal Transduction Ubiquitin Protein Ligase Activity Protein Kinase Activity Regulation Of Apoptotic Process Intracellular Signaling Cassette Structural Constituent Of Cytoskeleton Regulation Of Programmed Cell Death Response To Cytokine Response To Peptide Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Inflammatory Response Acetylcholine Receptor Activator Activity Cytoplasm Response To Light Stimulus Positive Regulation Of Post-translational Protein Modification Glial Cell Development Protein Serine Kinase Activity Post-translational Protein Modification Regulation Of Post-translational Protein Modification Nucleotide Binding P38MAPK Cascade Protein Modification By Small Protein Conjugation Regulation Of Protein Metabolic Process Regulation Of Intracellular Transport Protein Serine/threonine Kinase Activity Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Growth Regulation Of Synapse Organization Response To Radiation DNA Damage Response Protein Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Developmental Growth Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Modification Process	Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Multicellular Organismal Development Translation Regulator Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Development Positive Regulation Of Catabolic Process Regulation Of Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Multicellular Organismal Process Presynapse Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Developmental Process Regulation Of Nervous System Development Negative Regulation Of Metabolic Process RNA Strand Annealing Activity Positive Regulation Of Nervous System Development Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Metabolic Process Molecular Condensate Scaffold Activity Intracellular Membraneless Organelle Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Protein Heterodimerization Activity Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ubiquitin-dependent Protein Catabolic Process Euchromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Neurogenesis Protein Catabolic Process Regulation Of Protein Catabolic Process
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