APOBEC3C and UNKL

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		APOBEC3C	UNKL
Description		apolipoprotein B mRNA editing enzyme catalytic subunit 3C	unk like zinc finger
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm	Nucleus Cytoplasm Cytosol
	Molecular Function	RNA Binding Catalytic Activity Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding
	Biological Process	Immune System Process Transposable Element Silencing Negative Regulation Of Macromolecule Biosynthetic Process Cytidine To Uridine Editing Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Clearance Of Foreign Intracellular DNA Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Defense Response To Virus DNA Cytosine Deamination Defense Response To Symbiont	Protein Ubiquitination
Pathways		mRNA Editing: C to U Conversion Formation of the Editosome	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Response to methotrexate in juvenile idiopathic arthritis ( 24709693)	Refractive error ( 32231278) Serum immune biomarker levels ( 32066700)
Interacting Genes		32 interacting genes: ARIH2 CHTOP CUL5 FBXO7 HHEX HNRNPK MYO10 NXF1 PCBP2 PCBP3 PRPF31 PRR3 RBM7 RBMX RBMY1A1 RBMY1F RBMY1J SF1 SHBG SNRPA SNW1 SRPK2 STK4 SUN2 TRAF3 TRIB3 UBC UNKL ZNF250 ZNF408 ZNF48 ZNF581	42 interacting genes: APOBEC3C ATXN1L BAG3 BAG4 CABP2 CARD9 CPSF2 CPSF7 CREB5 CRYBA2 CTBP1 DDX50 DMRTB1 EXOSC7 EXOSC8 FBLN1 FRS3 HNRNPF HOOK1 HOXA1 KCTD9 KDM1A KRT31 LMO1 MGAT5B NID2 NTAQ1 POLR1C PPP1R16A QKI RAB26 RAC1 RBPMS RNF10 RPS28 SAXO4 SMARCD2 SRPK2 TFIP11 TGM7 TRIM55 TRIM63
Entrez ID		27350	64718
HPRD ID		09671	15612
Ensembl ID		ENSG00000244509	ENSG00000059145
Uniprot IDs		Q9NRW3	A0A0A0MRZ1 E9PDK2 Q9H9P5
PDB IDs		3VM8 3VOW
Enriched GO Terms of Interacting Partners?		Spliceosomal Complex MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing RNA Binding RNA Splicing Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding MRNA Processing Nucleus Positive Regulation Of RNA Splicing RNA Metabolic Process Regulation Of MRNA Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing, Via Transesterification Reactions Nucleic Acid Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of MRNA Metabolic Process Identical Protein Binding Nucleoplasm Ubiquitin Protein Ligase Binding Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Ribonucleoprotein Complex Viral RNA Genome Replication Nucleobase-containing Compound Metabolic Process Transcription Export Complex Regulation Of Primary Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Cul5-RING Ubiquitin Ligase Complex Negative Regulation Of CGAS/STING Signaling Pathway Protein Binding Regulation Of Gene Expression Catalytic Step 2 Spliceosome Viral Genome Replication Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Protein K48-linked Ubiquitination Nuclear Speck Ubiquitin Ligase Complex Negative Regulation Of RNA Splicing Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process CGAS/STING Signaling Pathway Ubiquitin-protein Transferase Activity Nucleolus 14-3-3 Protein Binding	RNA Binding U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing RNA Processing Transcription Coactivator Activity Nucleus RNA Metabolic Process MRNA Metabolic Process Negative Regulation Of Protein Targeting To Mitochondrion RNA 3'-end Processing Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Negative Regulation Of Establishment Of Protein Localization To Mitochondrion U4 SnRNA 3'-end Processing Identical Protein Binding RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) TRNA Decay Nuclear MRNA Surveillance Ruffle Assembly Protein Binding Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Adenyl-nucleotide Exchange Factor Activity MRNA Processing RRNA Catabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) MRNA Cleavage And Polyadenylation Specificity Factor Complex Macromolecule Metabolic Process Positive Regulation Of Myelination Regulation Of RNA Splicing
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