PCDH17 and ZP3

Number of citations of the paper that reports this interaction (PubMedID 19945174)
29

Data Source:
BioGRID (two hybrid)

		PCDH17	ZP3
Description		protocadherin 17	zona pellucida glycoprotein 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Presynaptic Membrane Postsynaptic Membrane Glutamatergic Synapse GABA-ergic Synapse	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Matrix Egg Coat
	Molecular Function	Calcium Ion Binding Protein Binding Cell Adhesion Molecule Binding	Extracellular Matrix Structural Constituent Protein Binding Carbohydrate Binding Acrosin Binding Structural Constituent Of Egg Coat Identical Protein Binding Receptor Ligand Activity
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Adult Behavior Negative Regulation Of Synaptic Transmission Synaptic Membrane Adhesion Presynaptic Active Zone Assembly Regulation Of Synaptic Vesicle Clustering	Positive Regulation Of Type IV Hypersensitivity Blastocyst Formation Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Leukocyte Migration Positive Regulation Of Humoral Immune Response Signal Transduction Single Fertilization Binding Of Sperm To Zona Pellucida Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-4 Production Egg Coat Formation Positive Regulation Of T Cell Proliferation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Oocyte Development Positive Regulation Of Inflammatory Response Positive Regulation Of Acrosome Reaction Negative Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth
Pathways			Interaction With Cumulus Cells And The Zona Pellucida
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 25673413) Body size at age 10 ( 32376654) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive function ( 25644384) Diastolic blood pressure ( 30224653) Diverticular disease ( 30177863) Experiencing mood swings ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Fish- and plant-related diet ( 32066663) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Mood instability ( 31168069) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Regular attendance at a religious group ( 29970889) Subcutaneous adipose tissue ( 26480920 22589738) Type 2 diabetes ( 30297969)	Parkinson disease and lewy body pathology ( 25663231)
Interacting Genes		7 interacting genes: NR1H2 OLFM4 SIAH1 TSC22D4 UBQLN4 YAF2 ZP3	11 interacting genes: ACR CLDN11 ENGASE FURIN MALL MICALL1 MRPS16 OR2L13 PCDH17 SPACA3 UBAP2L
Entrez ID		27253	7784
HPRD ID		15104	01690
Ensembl ID		ENSG00000118946	ENSG00000188372
Uniprot IDs		O14917	P21754
PDB IDs		6VFT
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of DNA-templated Transcription Positive Regulation Of High-density Lipoprotein Particle Assembly Regulation Of High-density Lipoprotein Particle Assembly Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Pancreatic Juice Secretion Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Type IV Hypersensitivity Egg Coat Formation Positive Regulation Of Antral Ovarian Follicle Growth Structural Constituent Of Egg Coat Regulation Of Acrosomal Vesicle Exocytosis Negative Regulation Of Autophagosome Maturation Nuclear Proteasome Complex Apolipoprotein A-I Receptor Binding Acrosin Binding Negative Regulation Of Binding Of Sperm To Zona Pellucida Egg Coat Regulation Of Type IV Hypersensitivity Negative Regulation Of Metabolic Process Negative Regulation Of Pinocytosis Regulation Of Binding Of Sperm To Zona Pellucida Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Ovarian Follicle Development Cytosolic Proteasome Complex Negative Regulation Of Type II Interferon-mediated Signaling Pathway Positive Regulation Of Hypersensitivity Negative Regulation Of Immune Response Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Acrosome Reaction Negative Regulation Of Cholesterol Storage K48-linked Polyubiquitin Modification-dependent Protein Binding	Acrosomal Matrix Sperm-egg Recognition Cell-cell Recognition Cell Recognition Binding Of Sperm To Zona Pellucida Acrosome Matrix Dispersal Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Mannosyl-glycoprotein Endo-beta-N-acetylglucosaminidase Activity Cytoplasmic Side Of Endosome Membrane Amidase Activity Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Slow Endocytic Recycling Axon Ensheathment Negative Regulation Of Receptor Catabolic Process Presynaptic Active Zone Assembly Protease Binding Acrosomal Vesicle Viral Translation Viral Life Cycle Serine-type Peptidase Activity Plasma Membrane Organization Cytokine Precursor Processing Nerve Growth Factor Binding Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of Synaptic Vesicle Clustering Serine-type Endopeptidase Activity Fucose Binding Positive Regulation Of Stress Granule Assembly Lysozyme Activity
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