PCDH17 and NR1H2

Number of citations of the paper that reports this interaction (PubMedID 15604093)
0

Data Source:
BioGRID (two hybrid)

		PCDH17	NR1H2
Description		protocadherin 17	nuclear receptor subfamily 1 group H member 2
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Presynaptic Membrane Postsynaptic Membrane Glutamatergic Synapse GABA-ergic Synapse	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Calcium Ion Binding Protein Binding Cell Adhesion Molecule Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Apolipoprotein A-I Receptor Binding Sequence-specific DNA Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding ATPase Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Adult Behavior Negative Regulation Of Synaptic Transmission Synaptic Membrane Adhesion Presynaptic Active Zone Assembly Regulation Of Synaptic Vesicle Clustering	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Hormone-mediated Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Storage Positive Regulation Of Lipid Storage Negative Regulation Of Cholesterol Storage Cell Differentiation Intracellular Receptor Signaling Pathway Response To Nutrient Levels Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Phosphatidylcholine Acyl-chain Remodeling Cholesterol Homeostasis MRNA Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Pinocytosis Negative Regulation Of Inflammatory Response Lipid Homeostasis Negative Regulation Of Type II Interferon-mediated Signaling Pathway Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of MiRNA Transcription Negative Regulation Of Response To Endoplasmic Reticulum Stress
Pathways			PPARA activates gene expression Nuclear Receptor transcription pathway SUMOylation of intracellular receptors VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Drugs			GW-3965 Benzenesulfinic acid TO-901317 1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL Diacerein Rhein
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 25673413) Body size at age 10 ( 32376654) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive function ( 25644384) Diastolic blood pressure ( 30224653) Diverticular disease ( 30177863) Experiencing mood swings ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Fish- and plant-related diet ( 32066663) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Mood instability ( 31168069) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Regular attendance at a religious group ( 29970889) Subcutaneous adipose tissue ( 26480920 22589738) Type 2 diabetes ( 30297969)
Interacting Genes		7 interacting genes: NR1H2 OLFM4 SIAH1 TSC22D4 UBQLN4 YAF2 ZP3	52 interacting genes: BAG6 CDKN1A CHD3 COL4A5 CSAD DNMT3L DUSP12 ERG28 FAF1 FOXO3 HDAC4 HMGXB4 ING3 KDM1A LAMC3 MDFI MED1 MPP1 NCOA1 NCOA3 NCOA6 NCOR1 NCOR2 NPY NR0B2 NRIP1 PCDH17 PPARA PPARD PPARG PRKCA RARA RHOU RMI1 ROBO2 RXRA RXRB RXRG SCG5 SIRT1 SMPD1 SORBS2 SPRY2 SUV39H1 TMEM161A TTC3 UBE2D1 UBE2I VDR VIM YY1 ZXDC
Entrez ID		27253	7376
HPRD ID		15104	02660
Ensembl ID		ENSG00000118946	ENSG00000131408
Uniprot IDs		O14917	F1D8P7 P55055
PDB IDs		6VFT	1P8D 1PQ6 1PQ9 1PQC 1UPV 1UPW 3KFC 3L0E 4DK7 4DK8 4NQA 4RAK 5HJP 5I4V 5JY3 5KYA 5KYJ 6JIO 6K9G 6K9H 6K9M 6S4N 6S4T 6S4U 6S5K
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of DNA-templated Transcription Positive Regulation Of High-density Lipoprotein Particle Assembly Regulation Of High-density Lipoprotein Particle Assembly Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Pancreatic Juice Secretion Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Type IV Hypersensitivity Egg Coat Formation Positive Regulation Of Antral Ovarian Follicle Growth Structural Constituent Of Egg Coat Regulation Of Acrosomal Vesicle Exocytosis Negative Regulation Of Autophagosome Maturation Nuclear Proteasome Complex Apolipoprotein A-I Receptor Binding Acrosin Binding Negative Regulation Of Binding Of Sperm To Zona Pellucida Egg Coat Regulation Of Type IV Hypersensitivity Negative Regulation Of Metabolic Process Negative Regulation Of Pinocytosis Regulation Of Binding Of Sperm To Zona Pellucida Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Ovarian Follicle Development Cytosolic Proteasome Complex Negative Regulation Of Type II Interferon-mediated Signaling Pathway Positive Regulation Of Hypersensitivity Negative Regulation Of Immune Response Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Acrosome Reaction Negative Regulation Of Cholesterol Storage K48-linked Polyubiquitin Modification-dependent Protein Binding	Nuclear Receptor-mediated Signaling Pathway Nuclear Retinoid X Receptor Binding Negative Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Receptor Binding Chromatin Negative Regulation Of MiRNA Transcription Nuclear Receptor Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Nuclear Steroid Receptor Activity Regulation Of MiRNA Transcription Intracellular Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Transcription By RNA Polymerase II Peroxisome Proliferator Activated Receptor Signaling Pathway RNA Polymerase II Transcription Regulator Complex Regulation Of Primary Metabolic Process Regulation Of MiRNA Metabolic Process Regulation Of RNA Metabolic Process Nucleoplasm MRNA Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Response To Nutrient Levels Response To Lipid Nuclear Retinoic Acid Receptor Binding Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Retinoic Acid-responsive Element Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process
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