KLHL20 and ARHGEF19

Number of citations of the paper that reports this interaction (PubMedID 26687681)
0

Data Source:
BioGRID (two hybrid)

		KLHL20	ARHGEF19
Description		kelch like family member 20	Rho guanine nucleotide exchange factor 19
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Actin Cytoskeleton PML Body Axon Dendrite Cul3-RING Ubiquitin Ligase Complex Cell Projection Perinuclear Region Of Cytoplasm	Cytosol
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Type II Interferon Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Golgi To Endosome Transport Cytoskeleton Organization Protein Transport Protein Ubiquitination Response To Interferon-alpha Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K33-linked Ubiquitination	Regulation Of Actin Cytoskeleton Organization Wound Healing Regulation Of Small GTPase Mediated Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Feeling miserable ( 29500382)	Alanine aminotransferase levels ( 33339817 33547301) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Facial morphology ( 31763980) Gamma glutamyl transferase levels ( 29403010 33339817) Initial pursuit acceleration ( 29064472) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)
Interacting Genes		82 interacting genes: ABLIM1 ACTA1 AOC1 ARHGAP10 ARHGEF11 ARHGEF12 ARHGEF19 ATG9A BCL6 BECN1 BEX1 BEX2 BRINP2 C1orf216 C21orf58 CASP8AP2 CC2D1A CEP126 CIDEC CIMIP1 CLCNKA COL8A1 CORO7 CRK CRMP1 DMAC2 DUSP21 ECT2 EIF3F ENKD1 EPAS1 ERG28 F13A1 FBLN1 FHL2 FIZ1 GBE1 GBP2 GMCL1 HR IVNS1ABP JMJD1C KLHL38 KLHL9 LMO2 LRIF1 LUC7L2 MESD MTNR1A NECAB3 NEDD9 NISCH NTAQ1 NUDCD3 NUP160 ORC4 PAPPA PDPK1 PGLS PIK3C3 PIN1 PML PNKD POLR3D PRKAG1 PRMT6 RACK1 RANBP3 RECK RFC2 SGTA SLC13A5 SLC3A2 STK16 SUV39H1 SVEP1 TFAP2D TNPO2 ULK1 USP20 VPS54 ZFAT	3 interacting genes: KLHL20 PAK5 RHOA
Entrez ID		27252	128272
HPRD ID		13918	10659
Ensembl ID		ENSG00000076321	ENSG00000142632
Uniprot IDs		Q9Y2M5	B4DN02 Q8IW93
PDB IDs		5YQ4 6GY5 8CIA	8YR7
Enriched GO Terms of Interacting Partners?		Protein Binding Midbody Phagophore Assembly Site Regulation Of Cytokinesis Cytoplasm Cellular Response To Glucose Starvation Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III, Type I	Negative Regulation Of Apoptotic Process Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Cytoskeleton Organization Negative Regulation Of Programmed Cell Death Type II Interferon Binding Aortic Valve Formation Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Skeletal Muscle Satellite Cell Migration Protein K33-linked Ubiquitination Beta Selection Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Bone Trabecula Morphogenesis Apolipoprotein A-I-mediated Signaling Pathway Roundabout Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Endothelin Forebrain Radial Glial Cell Differentiation Positive Regulation Of Lipase Activity Cleavage Furrow Formation Negative Regulation Of Cell Size Apical Junction Assembly Ossification Involved In Bone Maturation Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Podosome Assembly Negative Regulation Of Motor Neuron Apoptotic Process Dendrite Heart Valve Formation Endothelial Tube Morphogenesis Radial Glial Cell Differentiation Regulation Of Modification Of Postsynaptic Structure Motor Neuron Apoptotic Process Regulation Of Podosome Assembly Regulation Of Motor Neuron Apoptotic Process Cellular Response To Chemokine Positive Regulation Of Systemic Arterial Blood Pressure Golgi To Endosome Transport Response To Cytokine Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Establishment Of Epithelial Cell Apical/basal Polarity Response To Peptide Organelle Organization Apical Junction Complex Establishment Of Apical/basal Cell Polarity Regulation Of Aerobic Respiration Establishment Of Monopolar Cell Polarity
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